Apoptosis (Bos taurus)

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532CaspActivator of Cell DeathpFas LigandpApoptosisDNA FragmentationDegradationbbeMitochondrionIGF1R signaling pathwaybInterferon regulatory factorsep53 RelatedInhibitor of Cell DeathPMAIP1MIR29B1MIR29ACASP9MDM2BAK1TRAF3IRF1NFKB1FASBIRC2DIABLOAKT1GZMBTNFRSF21BADNFKBIACASP1RIPK1IRF2NFKBIBLTACASP4IRF6CASP3PRF1TNFRSF1AIGF1RRELACHUKBAXAPAF1TNFRSF1BCASP10BIRC3BIDTNFRSF25MAPK10TRAF1IKBKBIRF5DFFACYCSNFKBIBBBC3IRF3CASP2HRKTP73SCAF11CASP7MYCTNFIGF2CRADDIKBKGBOKTRAF2CFLARBCL2L2PIK3R1TRADDBIRC5IGF1TNFRSF10BJUNBNIP3LDFFBTRADDBCL2TNFRSF1AIRF7RELABCL2L1IRF4NFKBIETP531MAP2K4RIPK1CDKN2ACASP8BIRC4BADNFKBIAFASLGTNFSF10NFKBIEHELLSNFKB1FADDMCL1CASP6BCL2L11MAP3K1TP63MIR29B2


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP254 (r95107) with a 91.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed Europe PMC Scholia
  2. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed Europe PMC Scholia
  3. Mott JL, Kobayashi S, Bronk SF, Gores GJ; ''mir-29 regulates Mcl-1 protein expression and apoptosis.''; Oncogene, 2007 PubMed Europe PMC Scholia
  4. Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM; ''Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.''; Hepatology, 2010 PubMed Europe PMC Scholia
  5. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95783view14:36, 19 January 2018MkutmonHomology conversion update
81196view14:01, 3 August 2015Mkutmonfixed unconnected lines
80915view15:31, 30 June 2015Mkutmonhomology conversion
67048view09:59, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
63305view20:51, 9 May 2013MaintBotUpdated to 2013 gpml schema
63304view20:50, 9 May 2013MaintBotReverted to version '05:46, 9 May 2012' by MaintBot
63303view20:49, 9 May 2013MaintBotUpdated to 2013 gpml schema
48127view05:46, 9 May 2012MaintBotUpdating from human to fix xref duplication
40509view19:29, 1 March 2011MaintBotRemoved redundant pathway information and comments
36238view18:20, 11 March 2010KhanspersAdded APAF1 xref
35100view13:07, 11 February 2010MartijnVanIerseladded lit. ref.
33752view23:59, 8 December 2009MaintBotAutomatic update of empty xrefs
31659view11:38, 14 August 2009MaintBotFixed group labels
30587view22:11, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:207
APAF1GeneProductENSBTAG00000021661 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:317
BADGeneProductENSBTAG00000012511 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:572
BAK1GeneProductENSBTAG00000000428 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:578
BAXGeneProductENSBTAG00000013340 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:581
BBC3GeneProductNo homologues found for original id L:27113
BCL2GeneProductENSBTAG00000019302 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:596
BCL2L11GeneProductENSBTAG00000024105 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10018
BCL2L1GeneProductENSBTAG00000006526 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:598
BCL2L2GeneProductENSBTAG00000019692 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:599
BIDGeneProductENSBTAG00000013988 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:637
BIRC2GeneProductENSBTAG00000035735 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:329
BIRC3GeneProductENSBTAG00000024918 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:330
BIRC4GeneProductNo homologues found for original id L:331
BIRC5GeneProductENSBTAG00000013573 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:332
BNIP3LGeneProductENSBTAG00000021307 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:665
BOKGeneProductENSBTAG00000008711 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:666
CASP1GeneProductNo homologues found for original id L:834
CASP10GeneProductNo homologues found for original id L:843
CASP2GeneProductENSBTAG00000018159 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:835
CASP3GeneProductENSBTAG00000015874 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:836
CASP4GeneProductENSBTAG00000020884 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:837
CASP6GeneProductENSBTAG00000012537 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:839
CASP7GeneProductENSBTAG00000006615 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:840
CASP8GeneProductENSBTAG00000015718 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:841
CASP9GeneProductENSBTAG00000002472 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:842
CDKN2AGeneProductENSBTAG00000034220 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1029
CFLARGeneProductENSBTAG00000010998 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8837
CHUKGeneProductENSBTAG00000007591 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1147
CRADDGeneProductENSBTAG00000005107 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8738
CYCSGeneProductENSBTAG00000022613 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:54205
DFFAGeneProductENSBTAG00000013535 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1676
DFFBGeneProductENSBTAG00000020015 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1677
DIABLOGeneProductENSBTAG00000004199 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:56616
FADDGeneProductENSBTAG00000018274 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8772
FASGeneProductENSBTAG00000010785 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:355
FASLGGeneProductENSBTAG00000032808 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:356
GZMBGeneProductENSBTAG00000010057 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3002
HELLSGeneProductENSBTAG00000005979 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3070
HRKGeneProductENSBTAG00000047484 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8739
IGF1GeneProductENSBTAG00000011082 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3479
IGF1RGeneProductENSBTAG00000021527 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3480
IGF2GeneProductENSBTAG00000013066 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3481
IKBKBGeneProductENSBTAG00000007599 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3551
IKBKGGeneProductENSBTAG00000006268 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8517
IRF1GeneProductENSBTAG00000031231 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3659
IRF2GeneProductENSBTAG00000010002 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3660
IRF3GeneProductENSBTAG00000006633 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3661
IRF4GeneProductENSBTAG00000002929 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3662
IRF5GeneProductENSBTAG00000004989 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3663
IRF6GeneProductENSBTAG00000002849 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3664
IRF7GeneProductENSBTAG00000047680 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3665
JUNGeneProductENSBTAG00000004037 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3725
LTAGeneProductENSBTAG00000000016 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4049
MAP2K4GeneProductENSBTAG00000012103 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6416
MAP3K1GeneProductENSBTAG00000013790 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4214
MAPK10GeneProductENSBTAG00000020048 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5602
MCL1GeneProductENSBTAG00000031396 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4170
MDM2GeneProductENSBTAG00000010422 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4193
MIR29AGeneProduct
MIR29B1GeneProduct
MIR29B2GeneProduct
MYCGeneProductENSBTAG00000008409 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4609
NFKB1GeneProductENSBTAG00000020270 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4790
NFKBIAGeneProductENSBTAG00000016683 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4792
NFKBIBGeneProductENSBTAG00000001778 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4793
NFKBIEGeneProductENSBTAG00000013705 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4794
PIK3R1GeneProductENSBTAG00000010989 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5295
PMAIP1GeneProductNo homologues found for original id L:5366
PRF1GeneProductENSBTAG00000001008 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5551
RELAGeneProductENSBTAG00000013895 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5970
RIPK1GeneProductENSBTAG00000006378 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8737
SCAF11GeneProductENSBTAG00000001810 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9169
TNFGeneProductENSBTAG00000025471 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7124
TNFRSF10BGeneProductENSBTAG00000048226 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8795
TNFRSF1AGeneProductENSBTAG00000004211 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7132
TNFRSF1BGeneProductENSBTAG00000024928 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7133
TNFRSF21GeneProductENSBTAG00000020054 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:27242
TNFRSF25GeneProductENSBTAG00000006519 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8718
TNFSF10GeneProductENSBTAG00000018994 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8743
TP53GeneProductENSBTAG00000001069 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7157
TP63GeneProductENSBTAG00000015460 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8626
TP73GeneProductENSBTAG00000005812 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7161
TRADDGeneProductENSBTAG00000012642 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8717
TRAF1GeneProductENSBTAG00000003012 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7185
TRAF2GeneProductENSBTAG00000010497 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7186
TRAF3GeneProductENSBTAG00000013475 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7187

Annotated Interactions

No annotated interactions
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