Nod-like receptor (NLR) signaling pathway (Bos taurus)

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1-62p10transcriptionCARDNACHTCaspase-1p10Iأژآ؛Bأژآ±CARDdegradationPYDASCp20TAB1RIP2K63-linked UbCARDNod1NACHTNACHTPYDCARDPYDp20IL-1أ¯آ؟آ½ and IL-18KDNALP3NACHTPYDNod2NACHTPYDInflammasome pathwayTAB2ERBB2IPCD40MAPK8RELACHUKMDPIKBKBTriDAPCARDCARDCARDCARDEPHB2IKBKGMAPKDAMPSMAP3K7


Description

Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP288(80026) with a 64.0% conversion rate.

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Bibliography

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  1. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE; ''Nod-like proteins in immunity, inflammation and disease.''; Nat Immunol, 2006 PubMed Europe PMC Scholia
  2. Mariathasan S, Monack DM; ''Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.''; Nat Rev Immunol, 2007 PubMed Europe PMC Scholia
  3. Carneiro LA, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH; ''Nod-like proteins in inflammation and disease.''; J Pathol, 2008 PubMed Europe PMC Scholia
  4. Meylan E, Tschopp J, Karin M; ''Intracellular pattern recognition receptors in the host response.''; Nature, 2006 PubMed Europe PMC Scholia
  5. Kufer TA; ''Signal transduction pathways used by NLR-type innate immune receptors.''; Mol Biosyst, 2008 PubMed Europe PMC Scholia
  6. Shaw MH, Reimer T, Kim YG, Nu�ez G; ''NOD-like receptors (NLRs): bona fide intracellular microbial sensors.''; Curr Opin Immunol, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134195view18:24, 16 July 2024EgonwRemoved an empty, unused reference
134191view18:20, 16 July 2024EgonwRemoved template comments
117028view14:02, 16 May 2021EweitzModified title
89539view11:22, 16 September 2016Mkutmonremove redundant ontology tag in GPML
80851view15:28, 30 June 2015Mkutmonhomology conversion
71852view20:13, 18 October 2013MaintBotremoved data source from nodes without identifier
70192view01:59, 13 July 2013AlexanderPicoModified title
69950view20:37, 11 July 2013MaintBotModified description
63476view17:21, 10 May 2013MaintBotupdating gpml
40508view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
33751view23:59, 8 December 2009MaintBotAutomatic update of empty xrefs
32505view12:50, 17 August 2009MaintBotFixed text labels
32195view12:36, 15 August 2009MaintBotFixed text labels
31671view11:42, 14 August 2009MaintBotFixed group labels
31203view19:34, 13 August 2009MaintBotFixed text labels
30601view22:15, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CARDGeneProduct
CD40GeneProductENSBTAG00000020736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:958
CHUKGeneProductENSBTAG00000007591 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147
DAMPSMetabolite
EPHB2GeneProductENSBTAG00000045902 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2048
ERBB2IPGeneProductENSBTAG00000000415 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55914
IKBKBGeneProductENSBTAG00000007599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551
IKBKGGeneProductENSBTAG00000006268 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517
MAP3K7GeneProductENSBTAG00000002625 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885
MAPKGeneProduct
MAPK8GeneProductENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MDPMetabolite
RELAGeneProductENSBTAG00000013895 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970
TriDAPMetabolite

Annotated Interactions

No annotated interactions
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