Colanic acid building blocks biosynthesis (Saccharomyces cerevisiae)

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GDP-mannoseUDP-D-glucoseH2OH+UDP-galactoseUDP-D-glucuronateGDP-4-dehydro-6-deoxy-D-mannoseNADAlpha-D-Galactose-1-PhosphateUTPNADPH2OUDP-D-glucoseGDP-4-dehydro-6-L-deoxygalactosealpha-D-GalactoseUDP-D-glucoseUGP1GAL1ADPNADPHGAL7SEC53glucose-1-phosphateYHL012Wphosphateguanosine diphosphate fucoseGDPfructose-6-phosphateGAL10NADHmannose-1-phosphateglucose-1-phosphatepyrophosphatePMI40mannose-6-phosphateATPPSA1


Description

Colanic acid (or M antigen) is a type of extracellular polysaccharide. It consists of a polyanionic heteropolysaccharide that contains a nonstoichiometric combination of sugars such as D-glucose, L-fucoses, D-galactose, and D-glucuronate, which are decorated with O-acetyl and pyruvate side chains. Before assembly, the sugars must be activated in the form of nucleotide sugars. The process of assembling the colanic acid polysaccharide repeat takes place on the membrane lipid through a series of glycosyl transferases on the cytoplasmic side of the inner membrane. Once the single repeat is assembled, it is flipped to the periplasmic side and polymerized by the Wzy-dependent pathway.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
125511view01:54, 24 February 2023AlexanderPicoadded description
124605view19:30, 15 November 2022EgonwReplaced an old Wikidata identifier
117276view10:45, 20 May 2021EweitzModified title
107246view14:34, 17 September 2019MaintBotChEBI identifier normalization
107011view13:46, 17 September 2019MaintBotHMDB identifier normalization
96369view07:38, 10 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94081view12:23, 18 August 2017DeSlConnected last line.
94074view14:44, 17 August 2017DeSlAdded two IDs
94073view14:41, 17 August 2017DeSlConnected more lines+annotations for nodes; changed faulty ID for glucose-1-phosphate.
94072view14:21, 17 August 2017DeSlChanged textlabels to nodes, added IDs, connected lines, changed IDs for fructose/mannose from open to closed form.
89684view06:49, 25 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
89186view03:53, 23 August 2016AriuttaOntology Term : 'classic metabolic pathway' added !
72199view10:57, 27 October 2013EgonwConverted a bunch of metabolite to DataNodes.
69754view10:46, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69598view20:31, 8 July 2013MaintBotUpdated to 2013 gpml schema
41827view04:49, 2 March 2011MaintBotRemoved redundant pathway information and comments
20937view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Colanic Acid Building Blocks Biosynthesis]] moved to [[Pathway:WP121]]: Moved to stable identifier
12676view07:57, 17 May 2008MaintBotautomated metabolite conversion
8672view14:06, 7 January 2008MaintBotAdded to category $category
8670view14:06, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
Alpha-D-Galactose-1-PhosphateMetaboliteQ3082858 (Wikidata)
GAL10GeneProductS000000223 (SGD)
GAL1GeneProductS000000224 (SGD)
GAL7GeneProductS000000222 (SGD)
GDP-4-dehydro-6-L-deoxygalactoseMetabolite
GDP-4-dehydro-6-deoxy-D-mannoseMetaboliteCHEBI:16955 (ChEBI)
GDP-mannoseMetaboliteCHEBI:84880 (ChEBI)
GDPMetabolite146-91-8 (CAS)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
NADMetaboliteCHEBI:13389 (ChEBI)
NADHMetaboliteHMDB0001487 (HMDB)
NADPMetaboliteCHEBI:44409 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
PMI40GeneProductS000000805 (SGD)
PSA1GeneProductYDL055C (Ensembl)
SEC53GeneProductS000001849 (SGD)
UDP-D-glucoseMetaboliteCHEBI:46229 (ChEBI)
UDP-D-glucoseMetaboliteQ27102800 (Wikidata)
UDP-D-glucuronateMetaboliteCHEBI:17200 (ChEBI)
UDP-galactoseMetaboliteQ259015 (Wikidata)
UGP1GeneProductS000001518 (SGD)
UTPMetaboliteCHEBI:46398 (ChEBI)
YHL012WGeneProductS000001004 (SGD)
alpha-D-GalactoseMetaboliteCHEBI:28061 (ChEBI)
fructose-6-phosphateMetabolite15648788 (PubChem-compound)
glucose-1-phosphateMetaboliteCHEBI:16077 (ChEBI)
guanosine diphosphate fucoseMetabolite15839-70-0 (CAS)
mannose-1-phosphateMetaboliteCHEBI:35374 (ChEBI)
mannose-6-phosphateMetaboliteCHEBI:43896 (ChEBI)
phosphateMetabolite14265-44-2 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)

Annotated Interactions

No annotated interactions

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