TCA cycle (Anopheles gambiae)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Fatty Acid SynthesisMitochondrionGluconeogenesisElectron Transport ChainCytosolDegradation of Fatty AcidsContaining an Even Number of CarbonsDegradation of Fatty AcidsContaining an Odd Number of CarbonsGlycolysisAgaP_AGAP004742OxaloacetateMalateIsocitrateAgaP_AGAP009510AgaP_AGAP007852MalateSuccinateOxaloacetatePyruvateAcetyl-CoAalpha-KetoglutarateAgaP_AGAP012048CitrateAgaP_AGAP001884FumarateAgaP_AGAP001903Succinyl-CoAAgaP_AGAP004352AgaP_AGAP001312AgaP_AGAP004744PDK4PDK2PDK1AgaP_AGAP010276AgaP_AGAP008349PDP2AgaP_AGAP003030AgaP_AGAP010421PDHA2AgaP_AGAP004055AgaP_AGAP011629AgaP_AGAP006366AgaP_AGAP007786AgaP_AGAP002192AgaP_AGAP002728AgaP_AGAP003168AgaP_AGAP010429AgaP_AGAP010672AgaP_AGAP000618AgaP_AGAP007309PDHXAgaP_AGAP007975AgaP_AGAP011629Name: TCA cycleOrganism: Anopheles gambiae


Description

The [citric acid cycle](https://en.wikipedia.org/wiki/Citric_acid_cycle), also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from both [Albert Szent-Gyorgyi](https://en.wikipedia.org/wiki/Albert_Szent-Gy%C3%B6rgyi) and [Hans Krebs](https://en.wikipedia.org/wiki/Hans_Krebs_(biochemist)). Source: [Wikipedia]((https://en.wikipedia.org/wiki/Citric_acid_cycle))

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP78(r28870) with a 81% conversion rate.

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Quality Tags

Image:NeedsRef.pngAdd references
Image:Curated.pngApproved version
Image:Unconnected.pngFix interactions
Image:MissingXref.pngAnnotate nodes
Homology Converted

Ontology Terms

Pathway Ontology : ACE inhibitor drug pathway
 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
137023
Approved
view20:43, 26 February 2025KhanspersModified description
117225view09:30, 19 May 2021EweitzModified title
105889view08:57, 16 August 2019MkutmonHMDB identifier unification
87713view09:13, 25 July 2016MirellaKalafatiOntology Term : 'citric acid cycle pathway' added !
87712view09:13, 25 July 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
68436view19:10, 5 July 2013MaintBotUpdated to 2013 gpml schema
40467view18:47, 1 March 2011MaintBotRemoved redundant pathway information and comments
32284view13:09, 15 August 2009MaintBotFixed text labels
31834view12:27, 14 August 2009MaintBotFixed group labels
31312view20:14, 13 August 2009MaintBotFixed text labels
30796view23:42, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
AgaP_AGAP000618GeneProduct1271698 (Entrez Gene)
AgaP_AGAP001312GeneProduct1281865 (Entrez Gene)
AgaP_AGAP001884GeneProduct1281238 (Entrez Gene)
AgaP_AGAP001903GeneProduct1281223 (Entrez Gene)
AgaP_AGAP002192GeneProduct1269365 (Entrez Gene)
AgaP_AGAP002728GeneProduct1273240 (Entrez Gene)
AgaP_AGAP003030GeneProduct1272922 (Entrez Gene)
AgaP_AGAP003168GeneProduct1273838 (Entrez Gene)
AgaP_AGAP004055GeneProduct1270895 (Entrez Gene)
AgaP_AGAP004352GeneProduct1274499 (Entrez Gene)
AgaP_AGAP004742GeneProduct1278483 (Entrez Gene)
AgaP_AGAP004744GeneProduct1278481 (Entrez Gene)
AgaP_AGAP006366GeneProduct1276976 (Entrez Gene)
AgaP_AGAP007309GeneProduct1269860 (Entrez Gene)
AgaP_AGAP007786GeneProduct1278179 (Entrez Gene)
AgaP_AGAP007852GeneProduct1278105 (Entrez Gene)
AgaP_AGAP007975GeneProduct1277974 (Entrez Gene)
AgaP_AGAP008349GeneProduct1277632 (Entrez Gene)
AgaP_AGAP009510GeneProduct1271401 (Entrez Gene)
AgaP_AGAP010276GeneProduct1279699 (Entrez Gene)
AgaP_AGAP010421GeneProduct1272627 (Entrez Gene)
AgaP_AGAP010429GeneProduct1272618 (Entrez Gene)
AgaP_AGAP010672GeneProduct1272475 (Entrez Gene)
AgaP_AGAP011629GeneProduct1281003 (Entrez Gene)
AgaP_AGAP012048GeneProduct1280620 (Entrez Gene)
CitrateMetaboliteHMDB0000094 (HMDB)
FumarateMetaboliteHMDB0000134 (HMDB)
IsocitrateMetaboliteHMDB0000193 (HMDB)
MalateMetaboliteHMDB0000156 (HMDB)
OxaloacetateMetaboliteHMDB0000223 (HMDB)
PDHA2GeneProduct
PDHXGeneProduct
PDK1GeneProduct
PDK2GeneProduct
PDK4GeneProduct
PDP2GeneProduct
PyruvateMetaboliteHMDB0000243 (HMDB)
SuccinateMetaboliteHMDB0000254 (HMDB)
Succinyl-CoAMetaboliteHMDB0001022 (HMDB)
alpha-KetoglutarateMetabolite

Annotated Interactions

No annotated interactions
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