Retinol metabolism (Rattus norvegicus)

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3, 14?NucleusROLRE + dietary lipidsall-trans-4-oxo dehydro RACytochrome P450 family13,14 dehydro RALbeta-caroteneEnterocyte?chylomicronROL=retinol; RAL=retinaldehyde, RA = retinoic acid, RE = retinyl ester, RPE = retinal pigment epithelium ?all-trans ROL??Bloodbeta-caroteneROLRE + dietary lipids?13,14 dehydro ROL9-cis RAL9-cis ROL9-cis RAall-trans RARERA-binding proteinsall-trans RALRPE-specificPPAR pathwaysbeta-caroteneall-trans-4-oxo RALiver/other organsRE + dietary lipidsbeta-10'-apocarotenal11-cis binding protein13,14 dehydro RAROL-binding proteins11-cis ROL11-cis RALRENuclear receptorsbeta-caroteneRALRbp7RARbCyp26b1LratRdh5Adh1alpha-caroteneRbp4Aldh1a1zeaxanthinAldh1a2Rlbp1Bcmo1Bcmo1cryptoxanthinbeta-cryptoxanthinAldh1a3RxraAdh4Dhrs3Rdh12ARATRxrgAldh1a1RaraBcdo2Sult2b1Crabp2Cd36Sult1a1violaxanthinCrabp1lycopeneAldh1a2Bcmo1Rpe65RxrbRbp1RargluteinMAPKRdh12Cyp2e1LplRdh10Scarb1Abcg5Rdh5Rdh8Aldh1a3Scarb1Abcg8LratRetsatVitamin D3astaxanthincanthaxanthinRbp2Cyp26a1Npc1l17, 8, 17, 18, 20...1, 2, 6, 10-12, 164, 5, 99, 13, 15, 19


Description

This pathway is about carotenoid metabolism. It is mainly created by the NuGO focusteam on Carotenoid metabolism. Finally it was subject to a text mining workflow which added some additional entities.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP716(r30274) with a 76% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL; ''Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis.''; Eur J Pediatr, 1997 PubMed Europe PMC Scholia
  2. Boosalis MG, Snowdon DA, Tully CL, Gross MD; ''Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study.''; Nutrition, 1996 PubMed Europe PMC Scholia
  3. Bendich A, Olson JA; ''Biological actions of carotenoids.''; FASEB J, 1989 PubMed Europe PMC Scholia
  4. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, Beecher GR, Smith JC Jr; ''Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men.''; Am J Clin Nutr, 1992 PubMed Europe PMC Scholia
  5. Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr; ''Separation and identification of carotenoids and their oxidation products in the extracts of human plasma.''; Anal Chem, 1992 PubMed Europe PMC Scholia
  6. Czeczuga-Semeniuk E, Wolczynski S, Markiewicz W; ''Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue.''; Neoplasma, 2003 PubMed Europe PMC Scholia
  7. PubMed Europe PMC Scholia
  8. Hidiroglou M, Williams CJ; ''Interrelationships among liposoluble vitamins in ruminants.''; Am J Vet Res, 1986 PubMed Europe PMC Scholia
  9. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG; ''Carotenoids in the human macula and whole retina.''; Invest Ophthalmol Vis Sci, 1988 PubMed Europe PMC Scholia
  10. Ruhl CE, Everhart JE; ''Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States.''; Gastroenterology, 2003 PubMed Europe PMC Scholia
  11. PubMed Europe PMC Scholia
  12. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E; ''Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol.''; Am J Clin Nutr, 1994 PubMed Europe PMC Scholia
  13. PubMed Europe PMC Scholia
  14. Balmer JE, Blomhoff R; ''Gene expression regulation by retinoic acid.''; J Lipid Res, 2002 PubMed Europe PMC Scholia
  15. Sies H, Stahl W, Sundquist AR; ''Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids.''; Ann N Y Acad Sci, 1992 PubMed Europe PMC Scholia
  16. VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, Stacewicz-Sapuntzakis M, Mares-Perlman JA; ''Influence of using different sources of carotenoid data in epidemiologic studies.''; J Am Diet Assoc, 1996 PubMed Europe PMC Scholia
  17. PubMed Europe PMC Scholia
  18. Torma H, Rollman O, Binderup L, Michaelsson G; ''Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture.''; J Investig Dermatol Symp Proc, 1996 PubMed Europe PMC Scholia
  19. PubMed Europe PMC Scholia
  20. PubMed Europe PMC Scholia
  21. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, Levy J, Sharoni Y; ''Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.''; Nutr Cancer, 1999 PubMed Europe PMC Scholia
  22. PubMed Europe PMC Scholia
  23. Johansson S, Melhus H; ''Vitamin A antagonizes calcium response to vitamin D in man.''; J Bone Miner Res, 2001 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
124808view21:42, 11 December 2022AlexanderPicofixed citations
124779view06:29, 11 December 2022AlexanderPicofixed citations
106955view13:41, 17 September 2019MaintBotHMDB identifier normalization
74434view06:19, 20 April 2014EgonwFixed a PubMed ID.
71769view20:30, 17 October 2013MaintBotAutomated update of data sources
69335view18:50, 8 July 2013MaintBotUpdated to 2013 gpml schema
67628view11:35, 26 June 2013DdiglesOntology Term : 'retinol metabolic pathway' added !
59818view11:06, 8 March 2013EgonwWidended label with legenda.
59805view07:22, 8 March 2013EgonwConverted the beta carotenes into DataNodes with ChEBI annotation.
48059view17:52, 1 May 2012Strandcorrected database names - hmdbid to HMDB
47781view05:51, 6 April 2012KhanspersSpecify description
41646view02:33, 2 March 2011MaintBotRemoved redundant pathway information and comments
38719view19:33, 23 September 2010AlexanderPico
34048view19:01, 9 December 2009MaintBotAutomatic update of empty xrefs
32766view18:30, 4 September 2009MaintBotModified categories
30980view00:53, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ARATGeneProduct
Abcg5GeneProduct114628 (Entrez Gene)
Abcg8GeneProduct155192 (Entrez Gene)
Adh1GeneProduct24172 (Entrez Gene)
Adh4GeneProduct29646 (Entrez Gene)
Aldh1a1GeneProduct24188 (Entrez Gene)
Aldh1a2GeneProduct116676 (Entrez Gene)
Aldh1a3GeneProduct266603 (Entrez Gene)
Bcdo2GeneProduct
Bcmo1GeneProduct114106 (Entrez Gene)
Cd36GeneProduct29184 (Entrez Gene)
Crabp1GeneProduct25061 (Entrez Gene)
Crabp2GeneProduct29563 (Entrez Gene)
Cyp26a1GeneProduct154985 (Entrez Gene)
Cyp26b1GeneProduct312495 (Entrez Gene)
Cyp2e1GeneProduct25086 (Entrez Gene)
Dhrs3GeneProduct313689 (Entrez Gene)
LplGeneProduct24539 (Entrez Gene)
LratGeneProduct64047 (Entrez Gene)
MAPKGeneProduct
Npc1l1GeneProduct432367 (Entrez Gene)
RARbGeneProduct24706 (Entrez Gene)
RaraGeneProduct24705 (Entrez Gene)
RargGeneProduct685072 (Entrez Gene)
Rbp1GeneProduct25056 (Entrez Gene)
Rbp2GeneProduct24710 (Entrez Gene)
Rbp4GeneProduct25703 (Entrez Gene)
Rbp7GeneProduct362662 (Entrez Gene)
Rdh10GeneProduct353252 (Entrez Gene)
Rdh12GeneProduct314264 (Entrez Gene)
Rdh5GeneProduct366791 (Entrez Gene)
Rdh8GeneProduct690953 (Entrez Gene)
RetsatGeneProduct246298 (Entrez Gene)
Rlbp1GeneProduct293049 (Entrez Gene)
Rpe65GeneProduct89826 (Entrez Gene)
RxraGeneProduct25271 (Entrez Gene)
RxrbGeneProduct361801 (Entrez Gene)
RxrgGeneProduct83574 (Entrez Gene)
Scarb1GeneProduct25073 (Entrez Gene)
Sult1a1GeneProduct83783 (Entrez Gene)
Sult2b1GeneProduct292915 (Entrez Gene)
Vitamin D3MetaboliteHMDB0000876 (HMDB)
alpha-caroteneMetaboliteHMDB0003993 (HMDB)
astaxanthinMetaboliteHMDB0002204 (HMDB)
beta-caroteneMetaboliteCHEBI:17579 (ChEBI)
beta-cryptoxanthinMetaboliteHMDB0002268 (HMDB)
canthaxanthinMetaboliteHMDB0003154 (HMDB)
cryptoxanthinMetaboliteHMDB0002268 (HMDB)
luteinMetaboliteHMDB0003233 (HMDB)
lycopeneMetaboliteHMDB0003000 (HMDB)
violaxanthinMetaboliteHMDB0003101 (HMDB)
zeaxanthinMetaboliteHMDB0002789 (HMDB)

Annotated Interactions

No annotated interactions
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