Eicosanoid synthesis (Danio rerio)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Cell Membrane15-Hydroperoxy Eicosatetraenoic Acid6-Keto-Prostaglandin F2-alpha12-Hydroperoxy Eicosatetraenoic AcidThromboxane A3Prostaglandin E25-HETEPTGDS5-HPETEProstaglandin H2zgc:153024ptgislLeukotriene D4tbxas1Peroxidase?Thromboxane B2Prostaglandin I2Prostaglandin D2PGE2 9-ketoreducGGT1ALOX15BLeukotriene A4Prostaglandin F2aLeukotriene C4Leukotriene E4lta4hLOC56728412-HETEPeroxidase?15-HETEThromboxane A2Arachidonic acidPeroxidase?Leukotriene B4PGD2 11-ketoreducptgeslptgesALOX15ALOX15alox12ptgs1ptgs2bLOC791800DKEY-194N13.2PLA2G2Apla2g6pla2g6IPLA2(GAMMA)DKEY-194N13.2LOC791800Name: Eicosanoid synthesisLast Modified: 10/17/2013Organism: Danio rerio


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [Wikipedia](https://en.wikipedia.org/wiki/Eicosanoid)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 51% conversion rate.

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes
Homology Converted

Ontology Terms

 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
136926
Approved
view19:35, 26 February 2025KhanspersModified description
116859view10:55, 14 May 2021EweitzModified title
106066view11:58, 16 August 2019MaintBotHMDB identifier normalization
89463view13:13, 15 September 2016Mkutmonremove space in ontology term id
71523view19:22, 17 October 2013MaintBotAutomated update of data sources
68658view05:14, 6 July 2013MaintBotUpdated to 2013 gpml schema
67183view10:17, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
62791view16:33, 2 May 2013MaintBotUpdated UniProt data source
40827view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
35479view12:14, 12 February 2010Thomasadded literature
35474view12:13, 12 February 2010ThomasModified description
34213view21:32, 9 December 2009MaintBotAutomatic update of empty xrefs
31914view12:51, 14 August 2009MaintBotFixed group labels
31028view01:12, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
12-HETEMetabolite
15-HETEMetabolite
5-HETEMetabolite
5-HPETEMetaboliteHMDB0001193 (HMDB)
ALOX15GeneProduct
ALOX15BGeneProduct
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
DKEY-194N13.2GeneProduct567204 (Entrez Gene)
GGT1GeneProduct393387 (Entrez Gene)
IPLA2(GAMMA)GeneProduct
LOC567284GeneProduct567284 (Entrez Gene)
LOC791800GeneProduct791800 (Entrez Gene)
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene E4MetaboliteHMDB0002200 (HMDB)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
PLA2G2AGeneProduct
PTGDSGeneProduct336492 (Entrez Gene)
Peroxidase?GeneProduct
Prostaglandin D2MetaboliteHMDB0001403 (HMDB)
Prostaglandin F2aMetaboliteHMDB0001139 (HMDB)
Prostaglandin H2MetaboliteHMDB0001381 (HMDB)
Prostaglandin I2MetaboliteHMDB0001335 (HMDB)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)
alox12GeneProduct322732 (Entrez Gene)
lta4hGeneProduct406575 (Entrez Gene)
pla2g6GeneProduct406370 (Entrez Gene)
ptgesGeneProduct544666 (Entrez Gene)
ptgeslGeneProduct799964 (Entrez Gene)
ptgislGeneProduct559148 (Entrez Gene)
ptgs1GeneProduct246226 (Entrez Gene)
ptgs2bGeneProduct559020 (Entrez Gene)
tbxas1GeneProduct792041 (Entrez Gene)
zgc:153024GeneProduct768195 (Entrez Gene)

Annotated Interactions

No annotated interactions
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