Monoamine GPCRs (Danio rerio)

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Gs PathwayAdrenergicReceptorsDopamineReceptorsMuscarinicAcetylcholine ReceptorsGs PathwayGq/G11 PathwaySerotoninReceptorsHistamineReceptorsGi/Go Pathwaydrd3adra1bhtr7hrh1htr5badrb2chrm4aNorepinephrinehtr1dadra1dchrm3bdrd4htr1ehtr1badra1aHistaminehtr6Muscarinechrm2ahtr1aadrd2adra2bhrh2drd1Epinephrinehtr2cSerotoninhtr2aDopamineadra2chtr2badrb3achrm3chrm5adrd5adrb1Acetylcholine htr4htr5ahtr1fadra2a


Description

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: Wikipedia


Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. Monoamine neurotransmitters

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP58(r20799) with a 62% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118402view14:11, 27 May 2021EweitzOntology Term : 'G protein mediated signaling pathway' added !
106083view11:59, 16 August 2019MaintBotHMDB identifier normalization
97057view15:22, 26 April 2018AdoBioInfoConnected line. One unconnected line less = one second of sadisfaction.
96093view19:10, 15 February 2018KhanspersModified description
87367view09:54, 22 July 2016MaintBotadded missing graphids
81184view15:03, 31 July 2015Mkutmonfixed xref annotations
71534view19:23, 17 October 2013MaintBotAutomated update of data sources
68683view05:43, 6 July 2013MaintBotUpdated to 2013 gpml schema
57079view20:26, 20 January 2013EgonwUsed "PubChem-compound"
48311view04:36, 18 May 2012KhanspersUpdating PubChem xrefs
46425view20:47, 27 January 2012MaintBotAutomatic update of PubChem xrefs
40856view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
34238view21:40, 9 December 2009MaintBotAutomatic update of empty xrefs
32344view13:35, 15 August 2009MaintBotFixed text labels
31964view13:06, 14 August 2009MaintBotFixed group labels
31391view20:46, 13 August 2009MaintBotFixed text labels
31101view01:42, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Acetylcholine MetaboliteHMDB0000895 (HMDB)
DopamineMetabolite
EpinephrineMetaboliteHMDB0000068 (HMDB)
HistamineMetabolite
MuscarineMetabolite9308 (PubChem-compound)
NorepinephrineMetaboliteHMDB0000216 (HMDB)
SerotoninMetabolite
adra1aGeneProductENSDARG00000028725 (Ensembl)
adra1bGeneProductENSDARG00000011317 (Ensembl)
adra1dGeneProductENSDARG00000024101 (Ensembl)
adra2aGeneProduct266750 (Entrez Gene)
adra2bGeneProduct266751 (Entrez Gene)
adra2cGeneProduct266752 (Entrez Gene)
adrb1GeneProduct557194 (Entrez Gene)
adrb2GeneProduct
adrb3aGeneProduct558248 (Entrez Gene)
chrm2aGeneProduct352938 (Entrez Gene)
chrm3GeneProduct571679 (Entrez Gene)
chrm3bGeneProduct100149598 (Entrez Gene)
chrm4aGeneProduct100150701 (Entrez Gene)
chrm5aGeneProduct553978 (Entrez Gene)
drd1GeneProduct568126 (Entrez Gene)
drd2GeneProduct
drd3GeneProduct282554 (Entrez Gene)
drd4GeneProduct
drd5GeneProductENSDARG00000090669 (Ensembl)
hrh1GeneProduct735302 (Entrez Gene)
hrh2GeneProductENSDARG00000057479 (Ensembl)
htr1aaGeneProduct100001828 (Entrez Gene)
htr1bGeneProduct561647 (Entrez Gene)
htr1dGeneProductENSDARG00000054124 (Ensembl)
htr1eGeneProductENSDARG00000011468 (Ensembl)
htr1fGeneProductENSDARG00000002773 (Ensembl)
htr2aGeneProductENSDARG00000057029 (Ensembl)
htr2bGeneProductENSDARG00000070940 (Ensembl)
htr2cGeneProduct
htr4GeneProductENSDARG00000061940 (Ensembl)
htr5aGeneProduct100038775 (Entrez Gene)
htr5bGeneProduct
htr6GeneProductENSDARG00000016095 (Ensembl)
htr7GeneProductENSDARG00000056949 (Ensembl)

Annotated Interactions

No annotated interactions
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