Osteopontin signaling (Homo sapiens)

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Revision as of 19:11, 3 March 2025 by Khanspers (Talk | contribs)

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Description

Study of regulation of promatrix metalloproteinase-9 (MMP-9) by osteopontin (OPN) through IKK signaling pathway.

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP1434).

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Ontology Terms

Bibliography

Das R, Philip S, Mahabeleshwar GH, Bulbule A, Kundu GC; ''Osteopontin: it's role in regulation of cell motility and nuclear factor kappa B-mediated urokinase type plasminogen activator expression.''; IUBMB Life, 2005 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
137536	view	19:11, 3 March 2025	Khanspers	Modified description
126280	view	04:29, 20 April 2023	Egonw	License is CCZero
117813	view	14:46, 22 May 2021	Eweitz	Modified title
106571	view	21:16, 6 September 2019	Khanspers	Modified description
105768	view	19:38, 15 August 2019	Khanspers	Modified description
94913	view	00:09, 13 October 2017	Khanspers	converted interaction to line
94742	view	15:09, 5 October 2017	Egonw	Converted to decorative interactions to graphical lines.
78545	view	10:30, 7 January 2015	MaintBot	added missing graphIds
72145	view	10:09, 25 October 2013	Mkutmon	added datasource for ITGB3 and ITGAV
68956	view	17:38, 8 July 2013	MaintBot	Updated to 2013 gpml schema
67558	view	11:25, 26 June 2013	Ddigles	Ontology Term : 'signaling pathway pertinent to development' added !
45316	view	20:08, 7 October 2011	Khanspers	Ontology Term : 'signaling pathway' added !
41120	view	23:37, 1 March 2011	MaintBot	Removed redundant pathway information and comments
39762	view	07:35, 17 January 2011	AlexanderPico	more specific title
38779	view	00:09, 24 September 2010	Khanspers	Added complex
38778	view	00:08, 24 September 2010	Khanspers	Changed graphics
35194	view	15:26, 11 February 2010	Thomas	added literature and made cosmetic changes
33714	view	19:56, 7 December 2009	MaintBot	Modified categories
33375	view	14:36, 30 November 2009	MaintBot	Removed group label
33270	view	07:17, 14 November 2009	Uomoamare	Def
33269	view	07:06, 14 November 2009	Uomoamare	Modified description
33268	view	02:18, 14 November 2009	Uomoamare	OPN
33267	view	01:47, 14 November 2009	Uomoamare	Periodical save, work in progress
33226	view	13:18, 8 November 2009	Uomoamare	Specify description
33225	view	12:17, 8 November 2009	Uomoamare	OPN (pathway in progress)
33224	view	11:50, 8 November 2009	Uomoamare	New pathway

External references

DataNodes

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Name	Type	Database reference
ERK1	GeneProduct	5595 (Entrez Gene)
ERK2	GeneProduct	5594 (Entrez Gene)
IKK-alpha	GeneProduct	1147 (Entrez Gene)
IKK-beta	GeneProduct	3551 (Entrez Gene)
ITGAV	GeneProduct	3685 (Entrez Gene)
ITGB3	GeneProduct	3690 (Entrez Gene)
MEK1	GeneProduct	5604 (Entrez Gene)
MMP-9	GeneProduct	4318 (Entrez Gene)
NFKB1	GeneProduct	4790 (Entrez Gene)
NIK	GeneProduct	9020 (Entrez Gene)
PLAU	GeneProduct	5328 (Entrez Gene)
RELA	GeneProduct	5970 (Entrez Gene)
SPP1	GeneProduct	6696 (Entrez Gene)