Superpathway of branched chain amino acid biosynthesis (Saccharomyces cerevisiae)

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Description

The biosynthesis of branched-chain amino acids (BCAA) in S. cerevisiae involves a common pathway that metabolizes pyruvate to valine or -ketobutyrate (derived from threonine) to isoleucine. This pathway occurs in the mitochondrion until the final step, where the immediate precursor to valine or isoleucine is converted to its respective amino acid either in the mitochondrion (via Bat1p) or the cytosol (via Bat2p). In a branch of the common pathway, valines immediate precursor can instead be converted to -isopropylmalate via -isopropylmalate synthase (Leu4p and Leu9p), which is subsequently exported to the cytosol and metabolized to leucine in three additional steps.

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Ontology Terms

 

Bibliography

  1. ''superpathway of branched chain amino acid biosynthesis''; YeastPathways,

History

View all...
CompareRevisionActionTimeUserComment
135612view02:52, 7 October 2024KhanspersOntology Term : 'classic metabolic pathway' added !
135611view02:51, 7 October 2024KhanspersModified description
135610view02:50, 7 October 2024Khanspersupdated reference
135609view02:50, 7 October 2024Khansperssize
135608view02:49, 7 October 2024KhanspersModified title
135607view02:48, 7 October 2024Khanspersadded reference
135590view02:07, 5 October 2024Khanspersoverhaul
135589view22:26, 4 October 2024Khanspersoverhaul in progress
117306view11:18, 20 May 2021EweitzModified title
89683view06:26, 25 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
69820view14:36, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69608view20:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
67418view10:59, 26 June 2013DdiglesOntology Term : 'valine, leucine and isoleucine biosynthetic pathway' added !
41840view04:50, 2 March 2011MaintBotRemoved redundant pathway information and comments
21097view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Isoleucine Valine Leucinebiosynthesis]] moved to [[Pathway:WP198]]: Moved to stable identifier
12758view08:01, 17 May 2008MaintBotautomated metabolite conversion
8798view14:09, 7 January 2008MaintBotAdded to category $category
8796view14:09, 7 January 2008J.HeckmanUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(2R)-2,3-dihydroxy-3-methylbutanoateMetabolite49072 (ChEBI)
(2S)-2-isopropyl-3-oxosuccinateMetabolite17214 (ChEBI)
(2S)-2-isopropylmalateMetabolite1178 (ChEBI)
(3S)-3-methyl-2-oxopentanoateMetabolite35146 (ChEBI)
(R)-2,3-dihydroxy-3-methylpentanoateMetabolite49258 (ChEBI)
(S)-2-aceto-2-hydroxybutanoateMetabolite49256 (ChEBI)
(S)-2-acetolactateMetabolite58476 (ChEBI)
(Z)-2-aminobutenoateMetabolite58739 (ChEBI)
2-iminobutanoateMetabolite19796801 (PubChem-compound)
2-isopropylmaleateMetabolite58085 (ChEBI)
2-oxobutanoateMetabolite16763 (ChEBI)
2-oxoglutarateMetabolite16810 (ChEBI)
3-methyl-2-oxobutanoateMetabolite11851 (ChEBI)
4-methyl-2-oxopentanoateMetabolite17865 (ChEBI)
BAT1GeneProductS000001251 (SGD)
BAT2GeneProductS000003909 (SGD)
CO2MetaboliteCHEBI:16526 (ChEBI)
Coenzyme AMetabolite64885-97-8 (CAS)
H+MetaboliteHMDB59597 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
ILV1GeneProductS000000888 (SGD)
ILV2GeneProductS000004714 (SGD)
ILV3GeneProductS000003777 (SGD)
ILV5GeneProductS000004347 (SGD)
ILV6GeneProductS000000515 (SGD)
L-ValineMetabolite72-18-4 (CAS)
L-glutamateMetabolite29985 (ChEBI)
L-glutamateMetabolite56-86-0 (CAS)
L-isoleucineMetabolite58045 (ChEBI)
L-leucineMetabolite61-90-5 (CAS)
L-threonineMetabolite72-19-5 (CAS)
LEU1GeneProductS000002977 (SGD)
LEU2GeneProductS000000523 (SGD)
LEU4GeneProductS000005048 (SGD)
LEU9GeneProductS000005634 (SGD) minor isozyme
NAD+Metabolite57540 (ChEBI)
NADHMetabolite53-84-9 (CAS)
NADP+Metabolite58349 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
NH4+Metabolite28938 (ChEBI)
acetyl-CoAMetabolite72-89-9 (CAS)
pyruvateMetaboliteCHEBI:15361 (ChEBI)

Annotated Interactions

No annotated interactions

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