Type III interferon signaling (Homo sapiens)
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Description
The recently identified type III interferon group consists of three IFN-λ (lambda) genes encoding molecules called IFN-λ1, IFN-λ2 and IFN-λ3 (also called IL29, IL28A and IL28B respectively). These IFNs signal through a receptor complex consisting of IL10R2 (also called CRF2-4) and IFNLR1 (also called CRF2-12).
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.
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DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
IL10RB | GeneProduct | 3588 (Entrez Gene) ![]() | |
IL28A | GeneProduct | 282616 (Entrez Gene) ![]() | |
IL28B | GeneProduct | 282617 (Entrez Gene) ![]() | |
IL28RA | GeneProduct | 163702 (Entrez Gene) ![]() | |
IL29 | GeneProduct | 282618 (Entrez Gene) ![]() | |
IRF9 | GeneProduct | 10379 (Entrez Gene) ![]() | |
JAK1 | GeneProduct | 3716 (Entrez Gene) ![]() | |
STAT1 | GeneProduct | 6772 (Entrez Gene) ![]() | |
STAT2 | GeneProduct | 6773 (Entrez Gene) ![]() | |
TYK2 | GeneProduct | 7297 (Entrez Gene) ![]() |
Annotated Interactions
No annotated interactions