Type III interferon signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ISREISGF3 complexIL28BIL29IL28ASTAT1STAT1IL10RBTYK2JAK1IL28RASTAT2IRF9STAT1GASName: Type III interferon signalingOrganism: Homo sapiens


Description

The type III interferon group consists of three IFN-λ (lambda) genes encoding molecules called IFN-λ1, IFN-λ2 and IFN-λ3 (also called IL29, IL28A and IL28B respectively). These IFNs signal through a receptor complex consisting of IL10R2 (also called CRF2-4) and IFNLR1 (also called CRF2-12). Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2113).

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Quality Tags

Image:NeedsRef.pngAdd references
Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : chorismate metabolic pathway
 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
137744
Approved
view13:48, 7 March 2025EweitzModified description
137742view13:39, 7 March 2025EweitzAlign nodes
137741view12:36, 7 March 2025EweitzEconomize layout
137740view12:35, 7 March 2025EweitzIncrease font size
137739view12:34, 7 March 2025EweitzUpgrade to complexes, refine interactions
137738view12:32, 7 March 2025EweitzEconomize layout
137720view11:54, 7 March 2025EgonwModified description
105848view23:14, 15 August 2019KhanspersModified description
86876view07:41, 14 July 2016Mkutmonfixed redundant ontology tags
86875view07:40, 14 July 2016MkutmonOntology Term : 'interleukin-28B signaling pathway' added !
86874view07:40, 14 July 2016MkutmonOntology Term : 'interleukin-28A signaling pathway' added !
86873view07:39, 14 July 2016MkutmonOntology Term : 'PW:0000892' removed !
86872view07:39, 14 July 2016MkutmonOntology Term : 'interleukin-29 signaling pathway' added !
86871view07:39, 14 July 2016MkutmonOntology Term : 'PW:0000893' removed !
70107view18:58, 12 July 2013MaintBotupdated to 2013 schema
58406view22:12, 12 February 2013MaintBotModified categories
58123view13:44, 8 February 2013Sham.ukModified title
58122view13:43, 8 February 2013Sham.ukSpecify description
58121view13:42, 8 February 2013Sham.ukSpecify description
58118view13:19, 8 February 2013Sham.ukPeriodical save, work in progress
58117view13:18, 8 February 2013Sham.ukSpecify description
58116view13:14, 8 February 2013Sham.ukupdate
57857view18:38, 4 February 2013Sham.ukOntology Term : 'Jak-Stat signaling pathway' added !
57854view18:35, 4 February 2013Sham.ukOntology Term : 'interferon lambda3 signaling pathway' added !
57853view18:34, 4 February 2013Sham.ukOntology Term : 'interferon lambda2 signaling pathway' added !
57851view18:34, 4 February 2013Sham.ukOntology Term : 'interferon lambda1 signaling pathway' added !
57849view18:34, 4 February 2013Sham.ukModified description
57844view18:20, 4 February 2013MaintBotModified title
46945view14:01, 7 March 2012Sham.uknew pathway
46944view13:57, 7 March 2012Sham.ukNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
IL10RBGeneProduct3588 (Entrez Gene)
IL28AGeneProduct282616 (Entrez Gene)
IL28BGeneProduct282617 (Entrez Gene)
IL28RAGeneProduct163702 (Entrez Gene)
IL29GeneProduct282618 (Entrez Gene)
IRF9GeneProduct10379 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT2GeneProduct6773 (Entrez Gene)
TYK2GeneProduct7297 (Entrez Gene)

Annotated Interactions

No annotated interactions

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