Brain derived neurotrophic factor (Rattus norvegicus)

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4531NucleusMAPK PathwayCell survival, Hippocampal Plasticity,Long term potentiationApoptosis,Atrophy,Long term depression22RasMAP2K1plasminogenRafp75TrkBmBDNFPAI-1tPAproBDNFplasminErk2 (MAPK 1)proBDNFBDNF


Description

Brain-derived neurotrophic factor (BDNF) is a growth factor found in the central and peripheral nervous systems. BDNF binds to two well-characterized receptors, TrkB and p75 (aka, low-affinity nerve growth factor receptor) to influence neuronal cell survival and differentiation. In the hippocampus, BDNF activity is also implicated in learning and memory.

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Ontology Terms

 

Bibliography

  1. Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, Hempstead BL, Lu B; ''Activation of p75NTR by proBDNF facilitates hippocampal long-term depression.''; Nat Neurosci, 2005 PubMed Europe PMC Scholia
  2. Neeley EW, Berger R, Koenig JI, Leonard S; ''Prenatal stress differentially alters brain-derived neurotrophic factor expression and signaling across rat strains.''; Neuroscience, 2011 PubMed Europe PMC Scholia
  3. Ding Q, Ying Z, Gómez-Pinilla F; ''Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing.''; Neuroscience, 2011 PubMed Europe PMC Scholia
  4. Neeley EW, Berger R, Koenig JI, Leonard S; ''Prenatal stress differentially alters brain-derived neurotrophic factor expression and signaling across rat strains.''; Neuroscience, 2011 PubMed Europe PMC Scholia
  5. Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen S, Teng KK, Yung WH, Hempstead BL, Lu B; ''Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity.''; Science, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
90920view23:31, 17 December 2016AlexanderPicoModified description
70121view19:25, 12 July 2013MaintBotupdated to 2013 schema
70076view09:21, 12 July 2013Mkutmonfixed unconnected lines
67954view14:29, 28 June 2013DdiglesOntology Term : 'brain-derived neurotrophic factor signaling pathway' added !
58522view20:20, 14 February 2013MaintBotModified categories
47457view10:16, 20 March 2012SchmidtdavSpecify description
47345view15:49, 15 March 2012SchmidtdavPeriodical save, work in progress
47341view15:44, 15 March 2012SchmidtdavSpecify description
47340view15:39, 15 March 2012SchmidtdavPeriodical save, work in progress
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47314view14:13, 15 March 2012SchmidtdavPeriodical save, work in progress
47312view14:06, 15 March 2012SchmidtdavNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BDNFGeneProduct24225 (Entrez Gene)
Erk2 (MAPK 1)GeneProduct116590 (Entrez Gene)
MAP2K1GeneProduct170851 (Entrez Gene)
PAI-1GeneProduct24617 (Entrez Gene)
RafGeneProduct24703 (Entrez Gene)
RasGeneProduct24525 (Entrez Gene)
TrkBGeneProduct25054 (Entrez Gene)
mBDNFGeneProduct24225 (Entrez Gene)
p75GeneProduct24596 (Entrez Gene)
plasminGeneProduct
plasminogenGeneProduct85253 (Entrez Gene)
proBDNFGeneProduct24225 (Entrez Gene)
tPAGeneProduct25692 (Entrez Gene)

Annotated Interactions

No annotated interactions

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