BDNF pathway (Mus musculus)
From WikiPathways
Description
Brain-derived neurotrophic factor (BDNF) is a growth factor found in the central and peripheral nervous systems. BDNF binds to two well-characterized receptors, TrkB and p75 (aka, low-affinity nerve growth factor receptor) to influence neuronal cell survival and differentiation. In the hippocampus, BDNF activity is also implicated in learning and memory.
Quality Tags
Ontology Terms
Bibliography
View all... |
- Lassus P, Roux P, Zugasti O, Philips A, Fort P, Hibner U; ''Extinction of rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway.''; Oncogene, 2000 PubMed Europe PMC Scholia
- Yeo GS, Connie Hung CC, Rochford J, Keogh J, Gray J, Sivaramakrishnan S, O'Rahilly S, Farooqi IS; ''A de novo mutation affecting human TrkB associated with severe obesity and developmental delay.''; Nat Neurosci, 2004 PubMed Europe PMC Scholia
- Taylor RC, Cullen SP, Martin SJ; ''Apoptosis: controlled demolition at the cellular level.''; Nat Rev Mol Cell Biol, 2008 PubMed Europe PMC Scholia
- Cho E, Lee KJ, Seo JW, Byun CJ, Chung SJ, Suh DC, Carmeliet P, Koh JY, Kim JS, Lee JY; ''Neuroprotection by urokinase plasminogen activator in the hippocampus.''; Neurobiol Dis, 2012 PubMed Europe PMC Scholia
- Li Y, Liu J, Hudson M, Kim S, Hatch NE; ''FGF2 promotes Msx2 stimulated PC-1 expression via Frs2/MAPK signaling.''; J Cell Biochem, 2010 PubMed Europe PMC Scholia
- Thomas A, Giesler T, White E; ''p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway.''; Oncogene, 2000 PubMed Europe PMC Scholia
- Neeley EW, Berger R, Koenig JI, Leonard S; ''Prenatal stress differentially alters brain-derived neurotrophic factor expression and signaling across rat strains.''; Neuroscience, 2011 PubMed Europe PMC Scholia
- Thompson WL, Van Eldik LJ; ''Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected].''; Brain Res, 2009 PubMed Europe PMC Scholia
- Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y, Liu Y, Rui L; ''SH2B regulation of growth, metabolism, and longevity in both insects and mammals.''; Cell Metab, 2010 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
Apoptosis | Pathway | ||
Bax | GeneProduct | ENSMUSG00000003873 (Ensembl) ![]() | |
Bcl2 - Cell survival | GeneProduct | ENSMUSG00000057329 (Ensembl) ![]() | |
Bdnf | GeneProduct | ENSMUSG00000048482 (Ensembl) ![]() | |
Cdc42 | GeneProduct | ENSMUSG00000006699 (Ensembl) ![]() | |
Creb | GeneProduct | ENSMUSG00000025958 (Ensembl) ![]() | |
Frs2 | GeneProduct | ENSMUSG00000020170 (Ensembl) ![]() | |
Mapk | GeneProduct | ENSMUSG00000024558 (Ensembl) ![]() | |
NF-kappa-B | GeneProduct | ||
PAI-1 | GeneProduct | ENSMUSG00000037411 (Ensembl) ![]() | |
PLC-gamma | GeneProduct | ||
Plasmin | GeneProduct | ENSMUSG00000059481 (Ensembl) ![]() | |
Plasminogen | GeneProduct | ENSMUSG00000059481 (Ensembl) ![]() | |
Pro-Bdnf | GeneProduct | ENSMUSG00000048482 (Ensembl) ![]() | |
Rac1 | GeneProduct | ENSMUSG00000001847 (Ensembl) ![]() | |
Response Element | GeneProduct | ||
SH2B | GeneProduct | ||
Shc1 | GeneProduct | ENSMUSG00000042626 (Ensembl) ![]() | |
TrkB | GeneProduct | ENSMUSG00000055254 (Ensembl) ![]() | |
p53 | GeneProduct | ENSMUSG00000059552 (Ensembl) ![]() | |
p75 | GeneProduct | ENSMUSG00000000120 (Ensembl) ![]() | |
tPA | GeneProduct | ENSMUSG00000031538 (Ensembl) ![]() |
Annotated Interactions
No annotated interactions