Immune responses in the epidermis (Caenorhabditis elegans)
From WikiPathways
Description
"Regulation of immune responses in the epidermis by two largely parallel pathways. The p38 MAPK pathway (proteins in this pathway are in black letters) regulates the expression nlp-29, an AMP-encoding gene. A second AMP, encoded by cnc-2, is regulated by neuronally expressed dbl-1 that
actives TGFb pathway (blue letters) in the epidermis. The identity of the neurones and whether G-protein signalling is required for neuronal secretion of DBL-1 is not known."
Quality Tags
Ontology Terms
Bibliography
- Zugasti O, Ewbank JJ; ''Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-beta signaling pathway in Caenorhabditis elegans epidermis.''; Nat Immunol, 2009 PubMed Europe PMC Scholia
- Dierking K, Polanowska J, Omi S, Engelmann I, Gut M, Lembo F, Ewbank JJ, Pujol N; ''Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity.''; Cell Host Microbe, 2011 PubMed Europe PMC Scholia
- Ewbank JJ; ''Signaling in the immune response.''; WormBook, 2006 PubMed Europe PMC Scholia
- Zugasti O, Bose N, Squiban B, Belougne J, Kurz CL, Schroeder FC, Pujol N, Ewbank JJ; ''Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans.''; Nat Immunol, 2014 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
DAF-4 | Complex | C05D2.1 (WormBase) ![]() | |
DAG | Metabolite | CHEBI:18035 (ChEBI) ![]() | diacylglycerol |
DBL-1 | GeneProduct | T25F10.2 (WormBase) ![]() | |
DCAR-1 | GeneProduct | C06H5.7 (WormBase) ![]() | |
EGL-8 (PLCbeta) | GeneProduct | B0348.4 (WormBase) ![]() | |
ELT-3 | GeneProduct | K02B9.4 (WormBase) ![]() | |
GPA-12(Galpha) | GeneProduct | F18G5.3 (WormBase) ![]() | |
HPLA | Metabolite | HMDB0000755 (HMDB) ![]() | Through targeted metabolomics analysis we identified the tyrosine derivative 4-hydroxyphenyllactic acid (HPLA) as an endogenous ligand. Our findings reveal DCAR-1 and its cognate ligand HPLA to be triggers of the epidermal innate immune response in C. elegans and highlight the ancient role of GPCRs in host defense. |
IP3 | Metabolite | CHEBI:16595 (ChEBI) ![]() | |
NIPI-3 | GeneProduct | K09A9.1 (WormBase) ![]() | |
NIPI-4 | GeneProduct | F40A3.5 (WormBase) ![]() | NIPI-4 phenocopies STA-2 and SNF-12 |
NSY-1 | GeneProduct | F59A6.1 (WormBase) ![]() | |
NonCanonical
DBL-1 TGF-beta pathway | Pathway | WP2926 (WikiPathways) ![]() | |
PIP2 | Metabolite | CHEBI:18348 (ChEBI) ![]() | |
PKC-3 | GeneProduct | F09E5.1 (WormBase) ![]() | |
PLC-3 | GeneProduct | T01E8.3 (WormBase) ![]() | |
PMK-1 | GeneProduct | B0218.3 (WormBase) ![]() | |
RACK-1(Gbeta) | GeneProduct | K04D7.1 (WormBase) ![]() | |
SEK-1 | GeneProduct | R03G5.2 (WormBase) ![]() | |
SMA-3 | GeneProduct | R13F6.9 (WormBase) ![]() | Neither SMA-2 nor SMA-4 are required in this DBL-1 triggered response |
SMA-6 | Complex | C32D5.2 (WormBase) ![]() | |
SNF-12 | GeneProduct | ||
STA-2 | GeneProduct | F58E6.1 (WormBase) ![]() | |
TIR-1B | GeneProduct | F13B10.1 (WormBase) ![]() | |
TPA-1(PKC delta) | GeneProduct | B0545.1 (WormBase) ![]() | |
cnc-2 | GeneProduct | R09B5.3 (WormBase) ![]() | |
nlp-29 | GeneProduct | B0213.4 (WormBase) ![]() | |
p38 MAPK pathway | Pathway | WP2925 (WikiPathways) ![]() |
Annotated Interactions
No annotated interactions