Immune responses in the epidermis (Caenorhabditis elegans)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none PAMPsEpidermisPIP2DBL-1IP3DAGNIPI-4ELT-3DAF-4HPLANonCanonicalDBL-1 TGF-betapathwayDCAR-1p38 MAPKpathwaySNF-12SMA-6SMA-3cnc-2nlp-29PMK-1SEK-1NSY-1PKC-3TIR-1BTPA-1(PKC delta)PLC-3GPA-12(Galpha)NIPI-3RACK-1(Gbeta)EGL-8 (PLCbeta)STA-2STA-2SNF-12STA-2STA-2PSTA-2NIPI-4Name: Immune responses in the epidermisOrganism: Caenorhabditis elegans


Description

"Regulation of immune responses in the epidermis by two largely parallel pathways. The p38 MAPK pathway (proteins in this pathway are in black letters) regulates the expression nlp-29, an AMP-encoding gene. A second AMP, encoded by cnc-2, is regulated by neuronally expressed dbl-1 that actives TGFb pathway (blue letters) in the epidermis. The identity of the neurones and whether G-protein signalling is required for neuronal secretion of DBL-1 is not known."

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Quality Tags

Image:Curated.pngApproved version
Image:Unconnected.pngFix interactions
Image:MissingXref.pngAnnotate nodes

Ontology Terms

 

Bibliography

  1. Zugasti O, Ewbank JJ; ''Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-beta signaling pathway in Caenorhabditis elegans epidermis.''; Nat Immunol, 2009 PubMed Europe PMC Scholia
  2. Dierking K, Polanowska J, Omi S, Engelmann I, Gut M, Lembo F, Ewbank JJ, Pujol N; ''Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity.''; Cell Host Microbe, 2011 PubMed Europe PMC Scholia
  3. Ewbank JJ; ''Signaling in the immune response.''; WormBook, 2006 PubMed Europe PMC Scholia
  4. Zugasti O, Bose N, Squiban B, Belougne J, Kurz CL, Schroeder FC, Pujol N, Ewbank JJ; ''Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans.''; Nat Immunol, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134215
Approved
view07:49, 17 July 2024EgonwRemoved template comments
120941view06:23, 2 February 2022EgonwMade two pathways clickable
107081view14:16, 17 September 2019MaintBotChEBI identifier normalization
106024view11:54, 16 August 2019MaintBotHMDB identifier normalization
80645view07:06, 28 June 2015SusanAdded ID to STA-2
80644view07:01, 28 June 2015SusanAdded id for Sta-1
80642view23:45, 27 June 2015Kyookclarification of SNF-12, STA-2 relationships, added comments to NIPI-4, and SMA-3 dotted line based on J. Ewbank guidance. Need to add references.
80452view22:42, 23 June 2015Kyookpmk-1 - sta-2 arrow, sma-3 to snf-12 arrow, sta-2 regulation of nlp-29
80441view23:06, 22 June 2015Kyook'SMA-2' in JEwbank instructions should be "SMA-3'
80440view22:51, 22 June 2015Kyookresponding to JEwbank 6/22/15 e-mail request: There's no evidence for a sta-2-independent pmk-1-dependent control of nlp-29, so the direct pmk-1-nlp-29 could be removed.

There should a link from SMA-2, via SNF-12/STA-2/NIPI-4, to cnc-2

In the context of
80248view07:27, 28 May 2015Kyook
80235view23:04, 27 May 2015Kyook
80232view22:48, 27 May 2015Kyookchanged primary reference to Ewbank, 2006, WormBook
80231view22:45, 27 May 2015Kyook
80229view20:54, 27 May 2015KyookSNF-12 works with NIPI-4 downstream of PMK-1
80228view00:02, 27 May 2015Kyookconnected WP pathways
80226view21:57, 26 May 2015Kyookadded Dierking et al., 2011
80196view18:07, 20 May 2015Kyookadded HPLA and DCAR-1
80181view18:43, 18 May 2015Kyookupdate for WBook Chapter- removed inferred neuronal input
68464view20:25, 5 July 2013MaintBotUpdated to 2013 gpml schema
53143view02:08, 30 October 2012MaintBotModified categories
49172view00:35, 7 July 2012KyookOntology Term : 'signaling pathway in the innate immune response' added !
49171view00:34, 7 July 2012KyookSpecify description
49170view00:32, 7 July 2012KyookPeriodical save, work in progress
49168view00:21, 7 July 2012KyookNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
DAF-4ComplexC05D2.1 (WormBase)
DAGMetaboliteCHEBI:18035 (ChEBI) diacylglycerol
DBL-1GeneProductT25F10.2 (WormBase)
DCAR-1GeneProductC06H5.7 (WormBase)
EGL-8 (PLCbeta)GeneProductB0348.4 (WormBase)
ELT-3GeneProductK02B9.4 (WormBase)
GPA-12(Galpha)GeneProductF18G5.3 (WormBase)
HPLAMetaboliteHMDB0000755 (HMDB) Through targeted metabolomics analysis we identified the tyrosine derivative 4-hydroxyphenyllactic acid (HPLA) as an endogenous ligand. Our findings reveal DCAR-1 and its cognate ligand HPLA to be triggers of the epidermal innate immune response in C. elegans and highlight the ancient role of GPCRs in host defense.
IP3MetaboliteCHEBI:16595 (ChEBI)
NIPI-3GeneProductK09A9.1 (WormBase)
NIPI-4GeneProductF40A3.5 (WormBase) NIPI-4 phenocopies STA-2 and SNF-12
NSY-1GeneProductF59A6.1 (WormBase)
NonCanonical

DBL-1 TGF-beta

pathway		PathwayWP2926 (WikiPathways)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PKC-3GeneProductF09E5.1 (WormBase)
PLC-3GeneProductT01E8.3 (WormBase)
PMK-1GeneProductB0218.3 (WormBase)
RACK-1(Gbeta)GeneProductK04D7.1 (WormBase)
SEK-1GeneProductR03G5.2 (WormBase)
SMA-3GeneProductR13F6.9 (WormBase) Neither SMA-2 nor SMA-4 are required in this DBL-1 triggered response
SMA-6ComplexC32D5.2 (WormBase)
SNF-12GeneProduct
STA-2GeneProductF58E6.1 (WormBase)
TIR-1BGeneProductF13B10.1 (WormBase)
TPA-1(PKC delta)GeneProductB0545.1 (WormBase)
cnc-2GeneProductR09B5.3 (WormBase)
nlp-29GeneProductB0213.4 (WormBase)
p38 MAPK pathwayPathwayWP2925 (WikiPathways)

Annotated Interactions

No annotated interactions

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