Androgen receptor network in prostate cancer (Homo sapiens)
From WikiPathways
Description
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding either of the androgenic hormones, testosterone, or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression. The AR is important for therapeutic target in prostate cancer, thus many different inhibitors have been developed, primarily targeting the ligand binding domain of the protein, while inhibitors that target the N-terminal domain of the protein are still under development. Description source: Wikipedia
Quality Tags
Ontology Terms
Pathway Ontology : cancer pathway prostate cancer pathway
Disease : prostate cancer
Bibliography
- Liu LZ, Li C, Chen Q, Jing Y, Carpenter R, Jiang Y, Kung HF, Lai L, Jiang BH; ''MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1α expression.''; PLoS One, 2011 PubMed Europe PMC Scholia
- Schramedei K, Mörbt N, Pfeifer G, Läuter J, Rosolowski M, Tomm JM, von Bergen M, Horn F, Brocke-Heidrich K; ''MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4.''; Oncogene, 2011 PubMed Europe PMC Scholia
- Tomlins SA, Rhodes DR, Yu J, Varambally S, Mehra R, Perner S, Demichelis F, Helgeson BE, Laxman B, Morris DS, Cao Q, Cao X, Andrén O, Fall K, Johnson L, Wei JT, Shah RB, Al-Ahmadie H, Eastham JA, Eggener SE, Fine SW, Hotakainen K, Stenman UH, Tsodikov A, Gerald WL, Lilja H, Reuter VE, Kantoff PW, Scardino PT, Rubin MA, Bjartell AS, Chinnaiyan AM; ''The role of SPINK1 in ETS rearrangement-negative prostate cancers.''; Cancer Cell, 2008 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
17-alpha-OH-Pregnenolone | Metabolite | HMDB0000363 (HMDB) | |
17-alpha-OH-Progesterone | Metabolite | HMDB0000374 (HMDB) | |
4EBP1 | Protein | Q13541 (Uniprot-TrEMBL) | |
ABCC4 | GeneProduct | 10257 (Entrez Gene) | |
ACTL6A | GeneProduct | 86 (Entrez Gene) | |
ACTL6B | GeneProduct | 51412 (Entrez Gene) | |
AKT1 | Protein | P31749 (Uniprot-TrEMBL) | |
AR | Protein | 367 (Entrez Gene) | AR |
ARID1A | GeneProduct | 8289 (Entrez Gene) | |
ARID1B | GeneProduct | 57492 (Entrez Gene) | |
ASK1 | Protein | ||
ATF1 | GeneProduct | 466 (Entrez Gene) | |
ATM | Protein | Q13315 (Uniprot-TrEMBL) | |
ATR | Protein | Q13535 (Uniprot-TrEMBL) | |
Androstenediol | Metabolite | HMDB0005849 (HMDB) | |
Androstenedione | Metabolite | 63-05-8 (CAS) | |
BACH1 | Protein | ||
BAD | Protein | Q92934 (Uniprot-TrEMBL) | |
BARD1 | Protein | Q99728 (Uniprot-TrEMBL) | |
BAX | Protein | Q07812 (Uniprot-TrEMBL) | |
BCL2 | Protein | P10415 (Uniprot-TrEMBL) | |
BLM | Protein | P54132 (Uniprot-TrEMBL) | |
BRCA1 | Protein | P38398 (Uniprot-TrEMBL) | |
CASP3 | Protein | P42574 (Uniprot-TrEMBL) | |
CASP8 | Protein | Q14790 (Uniprot-TrEMBL) | |
CASP9 | Protein | P55211 (Uniprot-TrEMBL) | |
CCND1 | Protein | P24385 (Uniprot-TrEMBL) | |
CDC25A | GeneProduct | ENSG00000164045 (Ensembl) | |
CDC25B | GeneProduct | ENSG00000101224 (Ensembl) | |
CDC2 | Protein | P06493 (Uniprot-TrEMBL) | Oncogene |
CDK2 | Protein | P24941 (Uniprot-TrEMBL) | |
CDK4 | Protein | P11802 (Uniprot-TrEMBL) | |
CHK1 | Protein | O14757 (Uniprot-TrEMBL) | |
CHK2 | Protein | O96017 (Uniprot-TrEMBL) | Phosphrylated |
CRK | GeneProduct | 1398 (Entrez Gene) | |
CRKL | GeneProduct | 1399 (Entrez Gene) | |
CYP17A1 | GeneProduct | 1586 (Entrez Gene) | |
Cholesterol | Metabolite | 57-88-5 (CAS) | |
DOCK1 | GeneProduct | 1793 (Entrez Gene) | Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted) |
Dihydrotestosterone | Metabolite | HMDB0002961 (HMDB) | |
E2F1 | Protein | Q01094 (Uniprot-TrEMBL) | |
EIF4E1B | Protein | A6NMX2 (Uniprot-TrEMBL) | |
EIF4EBP1 | GeneProduct | 1978 (Entrez Gene) |
|
ELK1 | GeneProduct | 2002 (Entrez Gene) | |
ERG | GeneProduct | 2078 (Entrez Gene) | Fusion partner with TMPRSS2 in about 40% of prostate cancers |
ETV4 | GeneProduct | 2118 (Entrez Gene) | Fusion partner with TMPRSS2 in about 40% of prostate cancers |
Estradiol | Metabolite | 57-91-0 (CAS) | |
Estrone | Metabolite | 53-16-7 (CAS) | |
F13B | GeneProduct | 2165 (Entrez Gene) | |
FKBP5 | Protein | 2289 (Entrez Gene) | |
FOS | GeneProduct | 2353 (Entrez Gene) | |
FOXA1 | Protein | 3169 (Entrez Gene) | DNA licensing factor for AR. Frequently occupies regions in enhancers with DNA recognition elements close to AR ARE |
GAB1 | GeneProduct | 2549 (Entrez Gene) | |
GRB2 | GeneProduct | 2885 (Entrez Gene) | |
Glucocortocoid synthesis | Pathway | WP4523 (WikiPathways) | |
HGF | GeneProduct | 3082 (Entrez Gene) | |
HRAS | GeneProduct | 3265 (Entrez Gene) | |
HSD17B1 | GeneProduct | 3292 (Entrez Gene) | |
HSD17B2 | GeneProduct | 3294 (Entrez Gene) | |
HSD17B3 | GeneProduct | 3293 (Entrez Gene) | |
HSD17B4 | GeneProduct | 3295 (Entrez Gene) | |
HSD17B7 | GeneProduct | 51478 (Entrez Gene) | |
HSD3B1 | GeneProduct | 3283 (Entrez Gene) | |
HSD3B2 | GeneProduct | 3284 (Entrez Gene) | |
Hydroxyprogesterone aldolase | GeneProduct | 4.1.2.30 (Enzyme Nomenclature) | |
JAK1 | Protein | P23458 (Uniprot-TrEMBL) | |
JUN | GeneProduct | 3725 (Entrez Gene) | |
KLK2 | GeneProduct | 3817 (Entrez Gene) | |
KLK3 | GeneProduct | 354 (Entrez Gene) | |
MAP2K1 | GeneProduct | 5604 (Entrez Gene) | |
MAP2K2 | GeneProduct | 5605 (Entrez Gene) | |
MAP4K1 | GeneProduct | 11184 (Entrez Gene) | |
MAPK1 | GeneProduct | 5594 (Entrez Gene) | |
MAPK3 | GeneProduct | 5595 (Entrez Gene) | |
MAPK8 | GeneProduct | 5599 (Entrez Gene) | |
MDM2 | Protein | Q00987 (Uniprot-TrEMBL) | Oncogene |
MIR21 | Rna | ENSG00000284190 (Ensembl) | |
MMP1 | Protein | P03956 (Uniprot-TrEMBL) | |
MRE11 | Protein | P49959 (Uniprot-TrEMBL) | |
MSH2 | Protein | P43246 (Uniprot-TrEMBL) | |
MSH6 | Protein | P52701 (Uniprot-TrEMBL) | |
MTOR | Protein | P42345 (Uniprot-TrEMBL) | |
MYC | GeneProduct | 4609 (Entrez Gene) | |
MYC | Protein | P01106 (Uniprot-TrEMBL) | |
Met | GeneProduct | 24553 (Entrez Gene) | |
Mineralocortocoid synthesis | Pathway | WP4523 (WikiPathways) | |
NDRG1 | GeneProduct | 10397 (Entrez Gene) | |
NOXA1 | Protein | Q86UR1 (Uniprot-TrEMBL) | |
OCT1 | Protein | ||
PAK1 | GeneProduct | 5058 (Entrez Gene) | |
PIK3CA | GeneProduct | 5290 (Entrez Gene) | |
PLK1 | GeneProduct | ENSG00000166851 (Ensembl) | |
PRKDC | Protein | P78527 (Uniprot-TrEMBL) | |
PTEN | GeneProduct | 5728 (Entrez Gene) | |
PTK2B | GeneProduct | 2185 (Entrez Gene) | |
PTPN11 | GeneProduct | 5781 (Entrez Gene) | |
PUMA | Protein | ||
PXN | GeneProduct | 5829 (Entrez Gene) | |
Pregnenolone | Metabolite | 145-13-1 (CAS) | |
Progesterone | Metabolite | 57-83-0 (CAS) | |
Q8NBS1 | Protein | Q8NBS1 (Uniprot-TrEMBL) | |
RAD50 | Protein | Q92878 (Uniprot-TrEMBL) | |
RAF1 | GeneProduct | 5894 (Entrez Gene) | |
RAP1A | GeneProduct | 5906 (Entrez Gene) | |
RAP1B | GeneProduct | 5908 (Entrez Gene) | |
RAPGEF1 | GeneProduct | 2889 (Entrez Gene) | |
RASA1 | GeneProduct | 5921 (Entrez Gene) | |
RB1 | Protein | P06400 (Uniprot-TrEMBL) | |
RHEB | Protein | Q15382 (Uniprot-TrEMBL) | |
RICTOR | Protein | 253260 (Entrez Gene) | |
RPTOR | Protein | Q8N122 (Uniprot-TrEMBL) | |
SMAD2 | Protein | Q15796 (Uniprot-TrEMBL) | Tumor supressor |
SMAD3 | Protein | P84022 (Uniprot-TrEMBL) | |
SMARCA4 | GeneProduct | 6597 (Entrez Gene) | |
SMARCC1 | GeneProduct | 6599 (Entrez Gene) | |
SMARCC2 | GeneProduct | 6601 (Entrez Gene) | |
SMARCD1 | GeneProduct | 6602 (Entrez Gene) | |
SMARCD2 | GeneProduct | 6603 (Entrez Gene) | |
SMARCD3 | GeneProduct | 6604 (Entrez Gene) | |
SOS1 | GeneProduct | 6654 (Entrez Gene) | Son of sevenless homolog 1 (Drosophila) (predicted) |
SP1 | Protein | 6667 (Entrez Gene) | DNA licensing factor for AR. Frequently occupies regions in enhancers with DNA recognition elements close to AR ARE |
SPINK1 | GeneProduct | 6690 (Entrez Gene) |
|
SPINK1 | Protein | D6RIU5 (Uniprot-TrEMBL) | |
SPRY1 | GeneProduct | 10252 (Entrez Gene) | |
SPRY2 | GeneProduct | 10253 (Entrez Gene) | |
STAT1 | Protein | P42224 (Uniprot-TrEMBL) | |
STAT3 | GeneProduct | 6774 (Entrez Gene) | |
Steroid-19-Hydroxylase | GeneProduct | ENSG00000120054 (Ensembl) | |
TMPRSS2 | GeneProduct | 7113 (HGNC Accession number) | |
TP53 | Protein | P04637 (Uniprot-TrEMBL) | |
TSC1 | Protein | Q92574 (Uniprot-TrEMBL) | |
TSC2 | Protein | P49815 (Uniprot-TrEMBL) | |
Testosterone | Metabolite | 58-22-0 (CAS) | |
Translation | |||
dehydroepiandrosterone | Metabolite | 53-43-0 (CAS) | |
p13K | Protein | ||
p14 | Protein | ||
p15 | Protein | ||
p21 | Protein | ||
p27 | Protein | ||
p38 | GeneProduct | ENSG00000112062 (Ensembl) |
Annotated Interactions
No annotated interactions