Ubiquinol-6 biosynthesis from 4-hydroxybenzoate (Saccharomyces cerevisiae)
From WikiPathways
Description
The main ubiquinone in Saccharomyces cerevisiae and other Saccharomycetes species is ubiquinone-6. Biosynthesis of 4-hydroxybenzoate, one of the precursors, can occur in yeast by two different paths - it may be produced directly from chorismate by the chorismate pyruvate-lyase reaction (similar to the common pathway in prokaryotes), or it can be synthesized from L-tyrosine, similar to higher eukaryotes (see 4-hydroxybenzoate biosynthesis I (eukaryotes)). At least 10 genes (COQ1-COQ10) have been shown to be required for synthesis of ubiquinone in Saccharomyces cerevisiae.
At least six of these proteins (COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9) were shown to form a complex, which may be attached to the mitochindria inner membrane by the product of COQ2, an integral membrane protein.
Description adapted from https://pathway.yeastgenome.org/.Quality Tags
Ontology Terms
Saving...Bibliography
- ''ubiquinol-6 biosynthesis from 4-hydroxybenzoate (eukaryotic)''; YeastPathways,
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| 2-hexaprenyl-6-methoxyphenol | Metabolite | 1109 (ChEBI)  | |
| 2-methoxy-6-all trans-hexaprenyl-1,4-benzoquinol | Metabolite | 61472 (ChEBI) | |
| 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate | Metabolite | 58373 (ChEBI) | |
| 3-demethylubiquinol-6 | Metabolite | 64253 (ChEBI) | |
| 3-hexaprenyl-4-hydroxybenzoate | Metabolite | 84492 (ChEBI) | |
| 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate | Metabolite | 57916 (ChEBI) | |
| 4-hydroxybenzoate | Metabolite | 30763 (ChEBI) | |
| 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol | Metabolite | 61473 (ChEBI) | |
| CAT5 | GeneProduct | S000005651 (SGD) | |
| CO2 | Metabolite | 16526 (ChEBI) | |
| COQ2 | GeneProduct | S000005324 (SGD) | |
| COQ3 | GeneProduct | S000005456 (SGD) | |
| COQ5 | GeneProduct | S000004578 (SGD) | |
| COQ6 | GeneProduct | S000003487 (SGD) | |
| H+ | Metabolite | 15378 (ChEBI) | |
| H2O | Metabolite | 15377 (ChEBI) | |
| NADP+ | Metabolite | 58349 (ChEBI) | |
| NADPH | Metabolite | 57783 (ChEBI) | |
| O2 | Metabolite | 15379 (ChEBI) | |
| S-adenosyl-L-homocysteine | Metabolite | 57856 (ChEBI) | |
| S-adenosyl-L-methionine | Metabolite | 59789 (ChEBI) | |
| a reduced electron acceptor | Metabolite | 17499 (ChEBI) | |
| all-trans-hexaprenyl diphosphate | Metabolite | 58179 (ChEBI) | |
| an oxidized electron acceptor | Metabolite | 15339 (ChEBI) | |
| pyrophosphate | Metabolite | 2466-09-3 (CAS) | |
| ubiquinol-6 | Metabolite | 52970 (ChEBI) |
Annotated Interactions
No annotated interactions
