Acetaminophen synthesis (Escherichia coli)

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2Escherichia coli4-amino-4-deoxychorismatenhoA4-AminophenolAcetaminophen4ABH (muschroom)ChorismatepabAp-Aminobenzoic acid1AcetaminophenpabBpabCSynechocystis sp. PCC 6803Ammonia4ABH (muschroom)Chorismate1nhoA4-AminophenolAnthranilatetrpE


Description

Synthetic biology approaches to acetaminophen production. The first reaction path in E.coli has been successfully tested experimentally. The second path in Synechocystis is proposed hypothetically by Menezes, et al. in a study considering synthetic biology approaches to resource utilization on future space missions.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Mizutani Y, Narikawa T, Satoh T, Sakurai N, Kaji H, Yamada S, Samejima T; ''A new UV method for serum gamma-glutamyltransferase assay using recombinant 4-aminobenzoate hydroxylase as a coupling enzyme.''; J Biochem, 1999 PubMed Europe PMC Scholia
  2. Menezes AA, Cumbers J, Hogan JA, Arkin AP; ''Towards synthetic biological approaches to resource utilization on space missions.''; J R Soc Interface, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106102view12:01, 16 August 2019MaintBotHMDB identifier normalization
88729view20:29, 12 August 2016MaintBotOntology Term : 'paracetamol drug pathway' added !
88728view20:29, 12 August 2016MaintBotOntology Term : 'drug pathway' added !
88727view20:28, 12 August 2016MaintBotOntology Term : 'classic metabolic pathway' added !
78724view12:05, 20 January 2015Bart SmeetsModified title
78203view22:05, 11 December 2014AlexanderPicoModified description
78202view22:00, 11 December 2014AlexanderPicoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4-AminophenolMetaboliteHMDB0001169 (HMDB)
4-amino-4-deoxychorismateMetaboliteCHEBI:35181 (ChEBI)
4ABH (muschroom)GeneProduct
AcetaminophenMetaboliteHMDB0001859 (HMDB)
AmmoniaMetaboliteHMDB0000051 (HMDB)
AnthranilateMetabolite227 (PubChem-compound)
ChorismateMetaboliteHMDB0012199 (HMDB)
nhoAGeneProductb1463 (Ensembl)
p-Aminobenzoic acidMetaboliteHMDB0001392 (HMDB)
pabAGeneProductb3360 (Ensembl)
pabBGeneProductb1812 (Ensembl)
pabCGeneProductb1096 (Ensembl)
trpEGeneProductb1264 (Ensembl)

Annotated Interactions

No annotated interactions

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