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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Intravasal pressure /stretch +p Reduction of intracellular Ca2+ concentration RELAXCATION Crossbreidge Myofilaments Hyperpolarization +p Vasoconstrictors Reduction of contractile system Ca2+ sensitivity Contraction -p Depolarization IRAG Ca2+ Ca2+ CAMP Angiotensin II BNP IP3 ANP PGI2 Arachidonate Norepinephrine Adrenomedullin K+ Gs EET DAG CPI-17 Adenosine RhOA 20-HETE NO Arachidonic acid metabolism PKG Ca2+ CaD CNP cGMP Endothelin K+ CGRP Calcium signal Pathway vasopressin PPP1CA PPP1R12A PPP1R12C PPP1CC PPP1CB PPP1R12B CACNA1D CACNA1F CACNA1C CACNA1S MYLK4 MYLK2 MYLK3 MYLK ITPR2 ITPR3 ITPR1 ROCK2 ROCK1 CYP4A11 CYP4A22 ADRA1B AGTR1 ADRA1A EDNRA AVPR1B ADRA1D AVPR1A NPR-A NPR-B GUCY1A2 GUCY1B3 GUCY1A3 CALM CALM1 CALM3 CALML5 CALML6 CALM2 RAF1 BRAF ARAF PLA2G2C phospholipase A2 PLA2G2D4 phospholipase A2 PLA2G6 PLA2G4E PLA2G4F PLA2G2A PLA2G10 PLA2G2A PLA2G2E PLA2G2D1 PLA2G1B PLA2G3 PLA2G12B PLA2G5 PLA2G4A PLA2G2F PLA2G12A PLA2G4D PLA2G4B MYL6 MYL9 MHC MYL6B ADCY1 ADCY9 ADCY8 ADCY2 ADCY5 ADCY3 ADCY7 ADCY6 ADCY4 PTGIR ADORA2B RAMP3 RAMP2 CALCRL ADORA2A RAMP1 GNA11 GNAQ PRKACA PRKX PRKACB PRKCA PRKCB PRKCD PRKCH PRKCE PRKCG PRKCQ MAP2K1 MAP2K2 KCNMB1 KCNMB2 KCNMB4 KCNMB3 KCNU1 KCNMA1 MAPK1 MAPK3 ARHGEF12 ARHGEF11 ARHGEF1 ACTG2 ACTA2 GNA13 GNA12 PLCB1 PLCB4 PLCB2 PLCB3 CACNA1F CACNA1D CACNA1S CACNA1C KCNMB2 KCNU1 KCNMB3 KCNMB4 KCNMB1 KCNMA1 ITPR2 ITPR1 ITPR3 MYLK2 MYLK MYLK4 MYLK3 Myosin ACTG2 ACTA2 MYL6 MHC MYL9 MYL6B Myosin PPP1CC PPP1CB PPP1R12C PPP1CA PPP1R12B PPP1R12A Vasodilators +p +p +p +p +p +p +p +p -p Name: Vascular smooth muscle contraction Organism: Bos taurus
Description
Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood vessels. The main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to high blood pressure, while excessive vasodilation as in shock leads to low blood pressure (
http://en.wikipedia.org/wiki/Vascular_smooth_muscle ).
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