Quercetin and Nf-kB / AP-1 induced cell apoptosis (Bos taurus)

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1-4AP-1 transcription factor complexsmall MAFCell membrane phospholipids(Increases vasoconstriction)INFLAMMATIONE-boxMAFKCOX1FOSIKBKBArachidonic acidPhospholipase A2Prostaglandin H2ACOX2Prostaglandin G2BIKBAQuercetinMAFGNFKB1PBIKBAPNf-kBNOS1VEGFAAngiogenesisCarcinogenesisNFKB1JUNAP-1MMP1MetastasisGene boxE-boxGene boxAREROSinduces malformationinhibits dimerizationinhibition of ubiquitinationDNA damageCYP2A6carcinogenic metaboliteNFE2L2KEAP1NFE2L2NFE2L2Phase 2 enzymeProstaglandin I2Thromboxane A2Prostaglandin F2aProstaglandin D2Prostaglandin E2PGHS-2(Causes vasoconstriction; promotes platelet aggregation)(Causes vasodilation; inhibits platelet aggregation)(Induces vasoconstriction and secretion of IL-1 and IL-2)


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2435(80008) with a 90.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia
  2. Ala Y. Issaa, Suresh R. Volatea, Michael J. Wargovich; ''The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives''; Journal of Food Composition and Analysis, 2006 DOI Scholia
  3. Ricciotti E, FitzGerald GA; ''Prostaglandins and inflammation.''; Arterioscler Thromb Vasc Biol, 2011 PubMed Europe PMC Scholia
  4. Tanigawa S, Fujii M, Hou DX; ''Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin.''; Free Radic Biol Med, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134263view05:22, 18 July 2024EgonwRemoved template comments
125293view17:19, 31 January 2023LarsgwAdd DOI to reference
117593view11:35, 21 May 2021EweitzModified title
105998view11:52, 16 August 2019MaintBotHMDB identifier normalization
87627view08:54, 25 July 2016LindarieswijkOntology Term : 'apoptotic cell death pathway' added !
87365view09:50, 22 July 2016MaintBotadded missing graphids
80739view15:24, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACOX2GeneProductENSBTAG00000004178 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168306
AngiogenesisPathway
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
BIKBAProteinENSBTAG00000016683 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P25963
COX1GeneProductENSBTAG00000043561 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4512
CYP2A6GeneProductENSBTAG00000047815 (Ensembl)
  • one of several possible phase 1 enzymes
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000255974
CarcinogenesisPathway
DNA damagePathway
FOSGeneProductENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170345
IKBKBGeneProductENSBTAG00000007599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104365
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177606
KEAP1GeneProductENSBTAG00000003543 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079999
MAFGGeneProductENSBTAG00000000040 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4097
MAFKGeneProductENSBTAG00000019303 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7975
MMP1GeneProductENSBTAG00000048029 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196611
MetastasisPathway
NFE2L2GeneProductENSBTAG00000019255 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116044
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109320
NOS1GeneProductENSBTAG00000002023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000089250
PGHS-2GeneProductENSBTAG00000014127 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5743
Phase 2 enzyme Protein
Phospholipase A2GeneProduct
Prostaglandin D2MetaboliteHMDB0001403 (HMDB)
Prostaglandin E2MetaboliteHMDB0001220 (HMDB)
Prostaglandin F2aMetaboliteHMDB0001139 (HMDB)
Prostaglandin G2MetaboliteHMDB0003235 (HMDB)
Prostaglandin H2MetaboliteHMDB0001381 (HMDB)
Prostaglandin I2MetaboliteHMDB0001335 (HMDB)
QuercetinMetaboliteHMDB0005794 (HMDB)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
VEGFAGeneProductENSBTAG00000047561 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715
carcinogenic metaboliteMetabolite

Annotated Interactions

No annotated interactions
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