Differentiation pathway (Bos taurus)

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6SortDefinitive endoderm3D matrigel cultureFP6EndodermalAnterior endodermSerumCXCR2CyclopamineAscorbic acidSHHNT5ERetinoic acidA-83-01NOGBMP4SeleniumINHBATGFB1BMP4FGF2DAPTSB431542NiacinamideES/IPS cellsKITEGFVEGFAFGF4IGF-IHGFNOTCH1EGFBMP4NOGWNT3AMultipotent LungProgenitorsHindgut endodermMultipotent endodermalprogenitor cellsHGFFGF4EGFNODALFGF10Retinoic acidFGF10Intestinal Tissueخ² cellsPancreatic progenitorsHepatocytesHepaticprogenitorsBMP4VEGFAKITLGTPOFLT3LGKITLGCSF1IL6IL3VEGFABMP4KITLGTPOIL3EPOINHBAFGF2BMP4FLT3LGTPOFGF2VEGFAFGF2SB431542TGFB1PDGFBIL3IL6VEGFAKITLGIL11DKK1VEGFAWNT1DKK1WNT1VEGFATGFB3NTF4FGF2BMP4FSTNTF4BMP4FGF2GDF5HemangioblastErythropoietic cellsLymphoid progenitorsOsteoclastsEndothelial cellsCardiomyocytesSmooth muscle cellsSkeletal myoblastsOsteogenic cellsMesenchymal stem/precursor cellsAscorbic acidBeta-Glycerophosphoric acidDexamethasoneDexamethasoneINSINSTFOP-9cocultureOP-9 coculture Semisolid cultureOP-9 orMS-5cocultureSortSemisolid cultureMesenchymo-angioblastAdipogenicCellHematopoieticprogenitorsMonocyte/macrophageprogenitorChondrogeniccellsCardiovascular colonyforming cellsVEGFATPOEPOIL6IL3IL11CSF1RTNFSF11Primitive streakMesodermBMP4WNT2BWNT5A54WNT7BWNT2FGF2IL6IL6RBMP4OP-9 coculture MesodermalGABA neuronsEpidermisPA6/MS-5cocultureCortical layersOptic cupNeural progenitorsDA neuronsSort P75+, HNK1Cortical neuronsKeratinocytesAdherent cultureOligodendrocytesNueral retina(NR)Retinal Pigment epithelium (RPE)Neural crest stem cellsSpinal motor neuronsPhotoreceptorsculture on artificialmatrixUtriclestromacultureKSR or adherantcultureRetinal pigment epitheliumOctic hair cells3D matrigel cultureNeuroectodermAstrocytesSFEBq cultureEctodermFGF2INHBASHHNiacinamideTaurineIGF-IFGF8WNT1ALKVitamin ALEFTY1SHHBMP4CNTFNaltrexoneFGF2NODALDKK1PDGFARetinoic acidEGFFGF1FGF2NOGVitamin ASHHSHHINHBAINHBABMP4EctodermalIGF-I38TPOEPOFLT3LGFGF2


Description

This pathway provides an overview of the directed differentiation molecules used to induce early and derivative cell lineages from human pluripotent stem cells. The initial version of this pathway is a direct adaptation of the SnapShot "Directed Differentiation of Pluripotent Stem Cells" pathway authored by Luis A. Williams, Brandi N. Davis-Dusenbery, and Kevin C. Eggan, HHMI, Harvard University, Cell 149, May 25, 2012 Elsevier Inc. DOI 10.1016/j.cell.2012.05.015. http://download.cell.com/pdf/PIIS0092867412005946.pdf. This adaptation was generated by Meenakshi Venkatasubramanian and Krithika Ramasamy Subramanian at Cincinnati Children's Hospital in the laboratory of Nathan Salomonis.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2848(80009) with a 85.0% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
134266view06:37, 19 July 2024EgonwRemoved template comments
117496view11:03, 21 May 2021EweitzModified title
105914view11:40, 16 August 2019MkutmonHMDB identifier normalization
89941view13:55, 6 October 2016EgonwModified description
87894view12:51, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
80827view15:27, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A-83-01Metabolite16218924 (PubChem-compound)
ALKGeneProductENSBTAG00000007379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171094
Ascorbic acidMetaboliteHMDB0000044 (HMDB)
BMP4GeneProductENSBTAG00000003835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:652
Beta-Glycerophosphoric acidMetaboliteHMDB0002520 (HMDB)
CNTFGeneProductENSBTAG00000003624 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000242689
CSF1GeneProductENSBTAG00000000283 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184371
CSF1RGeneProductENSBTAG00000012771 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182578
CXCR2GeneProductENSBTAG00000026753 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163464
CyclopamineMetabolite442972 (PubChem-compound)
DAPTMetabolite5311272 (PubChem-compound) http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5311272&loc=ec_rcs
DKK1GeneProductENSBTAG00000014218 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107984
DexamethasoneMetaboliteHMDB0015364 (HMDB)
EGFGeneProduct
EPOGeneProductENSBTAG00000003430 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130427
FGF10GeneProduct
FGF1GeneProductENSBTAG00000005198 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113578
FGF2GeneProductENSBTAG00000005691 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685
FGF4GeneProductENSBTAG00000012563 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000075388
FGF8GeneProductENSBTAG00000001530 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107831
FLT3LGGeneProductENSBTAG00000038045 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090554
FSTGeneProductENSBTAG00000003329 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134363
GDF5GeneProductENSBTAG00000004429 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125965
HGFGeneProductENSBTAG00000017664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019991
IGF-IGeneProductENSBTAG00000011082 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000017427
IL11GeneProductENSBTAG00000047400 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000095752
IL3GeneProduct
IL6GeneProductENSBTAG00000014921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244
IL6RGeneProductENSBTAG00000018474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160712
INHBAGeneProductENSBTAG00000002912 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624
INSGeneProduct
KITGeneProductENSBTAG00000002699 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157404
KITLGGeneProductENSBTAG00000017549 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130
LEFTY1GeneProductENSBTAG00000002855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243709
NODALGeneProductENSBTAG00000013090 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000156574
NOGGeneProductENSBTAG00000040282 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183691
NOTCH1GeneProductENSBTAG00000022799 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4851
NT5EGeneProductENSBTAG00000045976 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135318
NTF4GeneProductENSBTAG00000047078 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000225950
NaltrexoneMetaboliteHMDB0014842 (HMDB)
NiacinamideMetaboliteHMDB0001406 (HMDB)
PDGFAGeneProductENSBTAG00000014541 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197461
PDGFBGeneProductENSBTAG00000021697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100311
Retinoic acidMetaboliteHMDB0001852 (HMDB)
SB431542Metabolite4521392 (PubChem-compound) http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4521392
SHHGeneProductENSBTAG00000024552 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164690
SeleniumMetaboliteHMDB0001349 (HMDB)
TFGeneProductENSBTAG00000007273 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091513
TGFB1GeneProductENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
TGFB3GeneProductENSBTAG00000012004 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119699
TNFSF11GeneProductENSBTAG00000008924 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120659
TPOGeneProduct
TaurineMetaboliteHMDB0000251 (HMDB)
VEGFAGeneProductENSBTAG00000047561 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715
Vitamin AMetaboliteHMDB0000305 (HMDB)
WNT1GeneProductENSBTAG00000015364 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125084
WNT2BGeneProductENSBTAG00000014291 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7482
WNT2GeneProductENSBTAG00000008097 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7472
WNT3AGeneProductENSBTAG00000039397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154342
WNT5AGeneProductENSBTAG00000020221 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7474
WNT7BGeneProductENSBTAG00000009532 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7477

Annotated Interactions

No annotated interactions
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