Serotonin receptor 2 and ELK-SRF / GATA4 signaling (Bos taurus)

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7, 10, 16, 31, 42...4, 6, 27, 34, 72...25, 26, 35, 36, 45...15, 6329, 59, 65, 68, 74...60769, 431, 6754, 8912, 23, 38, 64, 66...24, 93, 95, 1034633, 10620, 328518, 28, 55, 6930, 47, 48, 56, 62...84, 8690, 9128, 7122, 811137, 6114, 5019, 51, 77, 97, 1003, 17, 40, 53, 78RAS5HTR2BHTR2CRAF1PLCMAPKAPK21,4,5-Insp3MAP2K2RASGRF1ELK4GNAQserotoninHRASSRFCALCIUMMAP2K1RASGRP1MAPK3ELK1KRASITPR1GATA4HTR2AMAPK1NRAS44, 49, 52, 73, 835, 21, 39, 41, 58...13, 101


Description

This pathway depicts the downstream signaling of serotonin via receptors 2A, 2B, and 2C, resulting in the activation of ELK-SRF and GATA4.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP732(80010) with a 85.0% conversion rate.

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Bibliography

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  104. Puente LG, Stone JC, Ostergaard HL; ''Evidence for protein kinase C-dependent and -independent activation of mitogen-activated protein kinase in T cells: potential role of additional diacylglycerol binding proteins.''; J Immunol, 2000 PubMed Europe PMC Scholia
  105. Caloca MJ, Zugaza JL, Bustelo XR; ''Exchange factors of the RasGRP family mediate Ras activation in the Golgi.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  106. Nitsch RM, Deng M, Growdon JH, Wurtman RJ; ''Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion.''; J Biol Chem, 1996 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125627view01:55, 6 March 2023AlexanderPicoModified description
117601view11:37, 21 May 2021EweitzModified title
101987view06:33, 22 November 2018EgonwRemoved whitespace in PubMed identifiers.
101983view20:37, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
80869view15:29, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,4,5-Insp3Metabolite85166-31-0 (CAS) 1,4,5-Insp3
5HTR2BGeneProductENSBTAG00000039772 (Ensembl)
  • 5-hydroxytryptamine (serotonin) receptor 2B
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3357
CALCIUMMetabolite7440-70-2 (CAS)
ELK1GeneProductENSBTAG00000015817 (Ensembl)
  • ELK1, member of ETS oncogene family
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
ELK4GeneProductENSBTAG00000004953 (Ensembl)
  • ETS domain-containing protein Elk-4 (SRF accessory protein 1)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2005
GATA4GeneProductENSBTAG00000005425 (Ensembl)
  • GATA-binding protein 4/5/6
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2626
GNAQGeneProductENSBTAG00000009789 (Ensembl)
  • guanine nucleotide binding protein, alpha q polypeptide
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
HTR2AGeneProductENSBTAG00000013498 (Ensembl)
  • 5-hydroxytryptamine (serotonin) receptor 2A
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3356
HTR2CGeneProduct5-hydroxytryptamine (serotonin) receptor 2C
ITPR1GeneProductENSBTAG00000020455 (Ensembl)
  • inositol 1,4,5-triphosphate receptor 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3708
KRASGeneProduct
MAP2K1GeneProductENSBTAG00000033983 (Ensembl)
  • mitogen activated protein kinase kinase 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl)
  • mitogen activated protein kinase kinase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK1GeneProductENSBTAG00000010312 (Ensembl)
  • mitogen activated protein kinase 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK1
MAPK3GeneProductENSBTAG00000016156 (Ensembl)
  • mitogen activated protein kinase 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPKAPK2GeneProductENSBTAG00000038107 (Ensembl)
  • MAP kinase-activated protein kinase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9261
NRASGeneProductENSBTAG00000046797 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893
PLCProteinphospholipase C group
RAF1GeneProductENSBTAG00000045748 (Ensembl)
  • v-raf-leukemia viral oncogene 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RASGRF1GeneProductENSBTAG00000019940 (Ensembl)
  • RAS protein-specific guanine nucleotide-releasing factor 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5923
RASGRP1GeneProductENSBTAG00000021872 (Ensembl)
  • RAS guanyl releasing protein 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10125
SRFGeneProductENSBTAG00000012777 (Ensembl)
  • serum response factor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6722
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions
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