Drug induction of bile acid pathway (Bos taurus)

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1SensingHepatic uptakeHepatocyteEzetimibeABCB1SLCO1B1BA-RCyclosporinSLC51AClozapineTetrahydrocortisoneSLC10A1NR1H4Glycocholic acidCYP3A4CholesterolChlorpromazineSULT2A1BAATTroglitazoneCYP7A1Bile acidsMetabolitesBileBile ductTaurocholic acidBilirubinIsoursodeoxycholic acidDeoxycholic acidVDRNR1I3NR1I2MethylprednisoloneCimetidineSLC51BABCC4ABCB11ABCC3ABCC2PhospholipidsDigoxinClarithromyciErythromycinSilybinGlyburideTacrolimusTrabectedinPhominColchicineRanitidineOxiglutationeSynthesisConjugationSecretion


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2289(78511) with a 88.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. NGP E-Magazine; ''Mechanistic Disease Modeling''; http://www.ngpharma.com/article/Mechanistic-Disease-Modeling/, 2012

History

View all...
CompareRevisionActionTimeUserComment
128628view03:02, 17 February 2024EweitzEconomize layout, standardize case
128624view02:02, 17 February 2024EweitzOntology Term : 'hepatocyte' added !
120497view07:28, 9 December 2021EgonwReplaced an old PubChem CID with the new one
117499view11:04, 21 May 2021EweitzModified title
105930view11:46, 16 August 2019MaintBotHMDB identifier normalization
87244view09:57, 20 July 2016SusanOntology Term : 'bile acid signaling pathway' added !
87243view09:57, 20 July 2016SusanOntology Term : 'drug pathway' added !
80889view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCB11GeneProductENSBTAG00000026885 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8647
ABCB1GeneProductENSBTAG00000005997 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5243
ABCC2GeneProduct
ABCC3GeneProduct
ABCC4GeneProductENSBTAG00000046611 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10257
BA-RMetabolite
BAATGeneProductENSBTAG00000025760 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:570
Bile acidsMetaboliteCHEBI:3098 (ChEBI)
BilirubinMetaboliteHMDB0000054 (HMDB)
CYP3A4GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1576
CYP7A1GeneProductENSBTAG00000005287 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581
ChlorpromazineMetabolite2726 (PubChem-compound)
CholesterolMetaboliteHMDB0000067 (HMDB)
CimetidineMetabolite2756 (PubChem-compound)
ClarithromyciMetabolite84029 (PubChem-compound)
Clozapine Metabolite135398737 (PubChem-compound)
Colchicine Metabolite6167 (PubChem-compound)
Cyclosporin Metabolite5284373 (PubChem-compound)
Deoxycholic acidMetaboliteHMDB0000626 (HMDB)
DigoxinMetaboliteHMDB0001917 (HMDB)
ErythromycinMetabolite12560 (PubChem-compound)
Ezetimibe Metabolite150311 (PubChem-compound)
GlyburideMetabolite3488 (PubChem-compound)
Glycocholic acidMetaboliteHMDB0000138 (HMDB)
Isoursodeoxycholic acidMetaboliteHMDB0000686 (HMDB)
MethylprednisoloneMetabolite6741 (PubChem-compound)
NR1H4GeneProductENSBTAG00000013596 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9971
NR1I2GeneProductENSBTAG00000019557 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8856
NR1I3GeneProductENSBTAG00000009215 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9970
OxiglutationeMetabolite65359 (PubChem-compound)
Phomin Metabolite5311281 (PubChem-compound)
PhospholipidsMetaboliteCHEBI:16247 (ChEBI)
RanitidineMetaboliteHMDB0001930 (HMDB)
SLC10A1GeneProductENSBTAG00000001881 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6554
SLC51AGeneProductENSBTAG00000012347 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:200931
SLC51BGeneProductENSBTAG00000003737 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:123264
SLCO1B1GeneProductENSBTAG00000022329 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10599
SULT2A1GeneProductENSBTAG00000039971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6822
SilybinMetabolite31553 (PubChem-compound)
TacrolimusMetabolite445643 (PubChem-compound)
Taurocholic acidMetaboliteHMDB0000036 (HMDB)
TetrahydrocortisoneMetaboliteHMDB0000903 (HMDB)
Trabectedin Metabolite108150 (PubChem-compound)
TroglitazoneMetabolite5591 (PubChem-compound)
VDRGeneProductENSBTAG00000016414 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7421

Annotated Interactions

No annotated interactions
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