MFAP5-mediated ovarian cancer cell motility and invasiveness (Homo sapiens)

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Revision as of 22:01, 27 February 2025 by Khanspers (Talk | contribs)

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Description

A graphical summary of the molecular signaling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness.

Based on figure 6c in [Leung et al](https://www.ncbi.nlm.nih.gov/pubmed/25277212). Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3301).

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Ontology Terms

Bibliography

Leung CS, Yeung TL, Yip KP, Pradeep S, Balasubramanian L, Liu J, Wong KK, Mangala LS, Armaiz-Pena GN, Lopez-Berestein G, Sood AK, Birrer MJ, Mok SC; ''Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.''; Nat Commun, 2014 PubMed Europe PMC Scholia
Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
137085	view	22:01, 27 February 2025	Khanspers	Modified description
127230	view	20:08, 25 August 2023	Khanspers	added lit ref and updated description
127188	view	22:11, 9 August 2023	Khanspers	updated phosphosites
126996	view	19:27, 14 July 2023	Khanspers	clarify interactions, updated labels, some reactions
120029	view	23:19, 15 October 2021	Khanspers	updated phosphosites
108104	view	10:16, 29 November 2019	Fehrhart	Ontology Term : 'cancer pathway' added !
106638	view	21:02, 12 September 2019	Khanspers	Modified description
106199	view	12:09, 16 August 2019	MaintBot	HMDB identifier normalization
105459	view	05:09, 8 August 2019	Khanspers	Modified description
103743	view	20:48, 2 April 2019	Khanspers	Modified description
103742	view	20:47, 2 April 2019	Khanspers	Modified description
97674	view	11:23, 1 June 2018	AMTan	Ontology Term : 'ovarian cancer' added !
94277	view	18:09, 30 August 2017	Khanspers	phosphorylations, updated for clarity
87836	view	11:46, 25 July 2016	Elisa	Ontology Term : 'disease of cellular proliferation' added !
87835	view	11:46, 25 July 2016	Elisa	Ontology Term : 'disease pathway' added !
81279	view	04:54, 14 August 2015	Khanspers	Modified description
81278	view	04:52, 14 August 2015	Khanspers	New pathway

External references

DataNodes

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Name	Type	Database reference
CREB1	GeneProduct	ENSG00000118260 (Ensembl)
Ca2+	Metabolite	HMDB0000464 (HMDB)
DAG	Metabolite	HMDB0007098 (HMDB)
ERK1	GeneProduct	ENSG00000102882 (Ensembl)
ERK2	GeneProduct	ENSG00000100030 (Ensembl)
FAK	GeneProduct	ENSG00000169398 (Ensembl)
IP3	Metabolite	85166-31-0 (CAS)
ITGAV	GeneProduct	ENSG00000138448 (Ensembl)
ITGB3	GeneProduct	ENSG00000259207 (Ensembl)
ITPR3	GeneProduct	ENSG00000096433 (Ensembl)
JUN	GeneProduct	ENSG00000177606 (Ensembl)
MFAP5	GeneProduct	ENSG00000197614 (Ensembl)
PIP2	Metabolite	245126-95-8 (CAS)
PLCG1	GeneProduct	ENSG00000124181 (Ensembl)
PRKCQ	GeneProduct	ENSG00000065675 (Ensembl)
RYR3	GeneProduct	ENSG00000198838 (Ensembl)
TNNC1	GeneProduct	ENSG00000114854 (Ensembl)
Troponin C	GeneProduct	ENSG00000114854 (Ensembl)