Septum site determination (Escherichia coli)
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Description
In Escherichia coli, division site selection is regulated in part by the Min-protein system. Oscillations of the Min proteins from pole to pole every approximately 40 sec have been revealed by in vivo studies of GFP fusions. The dynamic oscillatory structures produced by the Min proteins, including a ring of MinE protein, compact polar zones of MinD, and zebra-striped oscillations in filamentous cells, remain unexplained. We show that the Min oscillations, including mutant phenotypes, can be accounted for by in vitro-observed interactions involving MinD and MinE, with a crucial role played by the rate of nucleotide exchange. Recent discoveries suggest that protein oscillations may play a general role in proper chromosome and plasmid partitioning. (Huang KC et al. 2003)
Quality Tags
 | Approved version |
 |  |
Ontology Terms
Saving...Pathway Ontology : methylmalonic aciduria, cobalamin-related pathway mitochondria dynamics pathway cobalamin metabolic pathway
Disease : methylmalonic acidemia methylmalonic aciduria and homocystinuria type cblF methylmalonic aciduria and homocystinuria type cblC vitamin B12 deficiency methylmalonic acidemia cb1A type methylmalonic aciduria and homocystinuria type cblD methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency methylmalonic acidemia cb1B type
Cell Type : metabolising cell eukaryotic cell
Bibliography
- Huang KC, Meir Y, Wingreen NS; ''Dynamic structures in Escherichia coli: spontaneous formation of MinE rings and MinD polar zones.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
History
External references
DataNodes
Name  | Type | Database reference | Comment |
|---|---|---|---|
| ADP | Metabolite | HMDB0001341 (HMDB)  | |
| ATP | Metabolite | HMDB0000538 (HMDB) | |
| MinD | Protein | P0AEZ3 (Uniprot-TrEMBL) | |
| MinE | Protein | P0A734 (Uniprot-TrEMBL) | |
| Phosphate | Metabolite | HMDB0001429 (HMDB) |
Annotated Interactions
No annotated interactions
