Photodynamic therapy-induced NF-kB survival signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none XProliferationVEGFACCND1ROSHypoxiaCSF2IL8IL6IL1BIL1AIL2TNFInflammationPTGS2ICAM1VCAM1CXCL2CD40LGSELEEGLN2IKBKBCHUKNFKB1RELARELNFKB2RELBXAngiogenesisMMP3MMP9VEGFAMMP2MMP1PTGS2TRAF6TNFTNFRSF1AGene transcriptionNFKB1RELARELNFKB2RELBPTGS2CFLARBIRC2BIRC5BIRC3BCL2A1BCL2L2SurvivalName: Photodynamic therapy-induced NF-kB survival signalingOrganism: Homo sapiens


Description

Photodynamic therapy may induce a pro-inflammatory and angiogenic response mediated by NF-κB.


Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3617).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M; ''Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies.''; Cancer Metastasis Rev, 2015 PubMed Europe PMC Scholia
  2. Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, Moerland PD, van Kampen AH, van Gulik TM, Heger M; ''Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells.''; BMC Cancer, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137121view23:06, 27 February 2025KhanspersModified description
128736view03:11, 21 February 2024EweitzUpgrade metabolite and disease nodes
106541view00:08, 6 September 2019KhanspersModified description
105514view06:04, 8 August 2019KhanspersModified description
88316view15:37, 1 August 2016FehrhartOntology Term : 'altered regulatory pathway' added !
88150view18:24, 26 July 2016AlexanderPicoModified title
86063view23:29, 28 June 2016KhanspersOntology Term : 'cancer' added !
85991view19:28, 22 June 2016KhanspersModified title
84547view19:15, 1 March 2016MaintBotTwo more groups
84546view19:14, 1 March 2016MaintBotConnected interactions and created groups
84535view20:08, 29 February 2016RuudweijerAdded reference.
84494view07:29, 26 February 2016RuudweijerModified title
84493view07:28, 26 February 2016RuudweijerModified description
84463view18:15, 25 February 2016RuudweijerNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
BCL2A1GeneProduct597 (Entrez Gene)
BCL2L2GeneProduct599 (Entrez Gene)
BIRC2GeneProduct329 (Entrez Gene)
BIRC3GeneProduct330 (Entrez Gene)
BIRC5GeneProduct332 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CD40LGGeneProduct959 (Entrez Gene)
CFLARGeneProduct8837 (Entrez Gene)
CHUKGeneProduct1147 (Entrez Gene)
CSF2GeneProduct1437 (Entrez Gene)
CXCL2GeneProduct2920 (Entrez Gene)
EGLN2GeneProduct112398 (Entrez Gene)
HypoxiaQ105688 (Wikidata)
ICAM1GeneProduct3383 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL2GeneProduct3558 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct3576 (Entrez Gene)
MMP1GeneProduct4312 (Entrez Gene)
MMP2GeneProduct4313 (Entrez Gene)
MMP3GeneProduct4314 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NFKB2GeneProduct4791 (Entrez Gene)
PTGS2GeneProduct5743 (Entrez Gene)
RELGeneProduct5966 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RELBGeneProduct5971 (Entrez Gene)
ROSMetabolite26523 (ChEBI)
SELEGeneProduct6401 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TNFRSF1AGeneProduct7132 (Entrez Gene)
TRAF6GeneProduct7189 (Entrez Gene)
VCAM1GeneProduct7412 (Entrez Gene)
VEGFAGeneProduct7422 (Entrez Gene)

Annotated Interactions

No annotated interactions

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