Novel intracellular components of RIG-I-like receptor pathway (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Type I interferonDDX17Short dsRNAUb-mediatedproteolysisTMEM173CYLDApoptosisMAPK8MAPK10MAPK9MAPK14MAPK13MAPK12MAPK11DDX3YDDX3XCXCL8TNFACXCL12CXCL10DDX58ISG15TRIM25ATG5ATG12NLRX1MAVSDHX58RNF125IFIH1DAKOTUD5TRAF3TRADDTANKAZI2TBKBP1FADDRIPK1SIKE1IKBKETBK1IKBKGCASP8CASP10PIN1IRF3IRF7IKBKGCHUKIKBKBNFKBIANFKBIBNFKB1RELAMAP3K7MAP3K1TRAF2TRAF6IRF3IRF7NFKB1RELAIFNGIFNA1IFNB1IFNEIFNKInflammatory cytokinesNucleus5'ppp-RNALong dsRNAViral pathogensUb-mediatedproteolysisMAPK signalingISG15SNW1Viral RNAViral RNAName: Novel intracellular components of RIG-I-like receptor pathwayOrganism: Homo sapiens


Description

Viral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initiate signaling pathways, triggering the innate antiviral response via production of type I interferons and inflammatory cytokines. RLR pathway genes are characterized by rapid evolution, viral protein interactions, limited sets of protein domains, specific TF regulation, and densely connected interaction networks. The study by van der Lee et al. (2015) identfied novel components, DDX17 and SNW1, for the RIG-I pathway. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3865)

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Quality Tags

Ontology Terms

 

Bibliography

  1. van der Lee R, Feng Q, Langereis MA, Ter Horst R, Szklarczyk R, Netea MG, Andeweg AC, van Kuppeveld FJ, Huynen MA; ''Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response.''; PLoS Comput Biol, 2015 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
137318view16:19, 1 March 2025EweitzStandardize case
137317view16:17, 1 March 2025EweitzFix typo
137316view16:16, 1 March 2025EweitzRefine layering of mitochondrion, nucleus
137315view16:15, 1 March 2025EweitzAlign nodes
137314view16:14, 1 March 2025EweitzEconomize layout
137311view16:07, 1 March 2025EweitzEconomize layout
137310view16:03, 1 March 2025EweitzTailor node width
137309view16:01, 1 March 2025EweitzIncrease font size
137221view09:00, 1 March 2025EgonwModified description
123636view09:43, 7 August 2022EgonwModified title
123123view18:07, 4 July 2022EgonwMade four pathways clickable
106524view23:45, 5 September 2019KhanspersModified description
105798view22:48, 15 August 2019KhanspersModified description
104869view19:51, 21 June 2019AlexanderPicoModified description
104868view19:48, 21 June 2019AlexanderPicoModified title
104581view12:47, 2 June 2019YtModified title
88186view00:44, 30 July 2016AlexanderPicoAdded newly discovered viral RNA-host RLR components
88185view00:39, 30 July 2016AlexanderPicoOntology Term : 'viral infectious disease' added !
88184view00:38, 30 July 2016AlexanderPicoOntology Term : 'signaling pathway in the innate immune response' added !
88183view00:38, 30 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
88182view00:38, 30 July 2016AlexanderPicoModified description
88181view00:23, 30 July 2016AlexanderPicoAdded literature reference
88180view00:22, 30 July 2016AlexanderPicofixed complex position
88179view00:21, 30 July 2016AlexanderPicoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
5'ppp-RNARna
ATG12GeneProductENSG00000145782 (Ensembl)
ATG5GeneProductENSG00000057663 (Ensembl)
AZI2GeneProductENSG00000163512 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
CASP10GeneProductENSG00000003400 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL12GeneProductENSG00000107562 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
CYLDGeneProductENSG00000083799 (Ensembl)
DAKGeneProductENSG00000149476 (Ensembl)
DDX17GeneProductENSG00000100201 (Ensembl)
DDX3XGeneProductENSG00000215301 (Ensembl)
DDX3YGeneProductENSG00000067048 (Ensembl)
DDX58GeneProductENSG00000107201 (Ensembl)
DHX58GeneProductENSG00000108771 (Ensembl)
FADDGeneProductENSG00000168040 (Ensembl)
IFIH1GeneProductENSG00000115267 (Ensembl)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNB1GeneProductENSG00000171855 (Ensembl)
IFNEGeneProductENSG00000184995 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IFNKGeneProductENSG00000147896 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKEGeneProductENSG00000263528 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
IRF3GeneProductENSG00000126456 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
ISG15GeneProductENSG00000187608 (Ensembl)
Long dsRNARna
MAP3K1GeneProductENSG00000095015 (Ensembl)
MAP3K7GeneProductENSG00000135341 (Ensembl)
MAPK signalingPathwayWP382 (WikiPathways)
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MAVSGeneProductENSG00000088888 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NFKBIBGeneProductENSG00000104825 (Ensembl)
NLRX1GeneProductENSG00000160703 (Ensembl)
OTUD5GeneProductENSG00000068308 (Ensembl)
PIN1GeneProductENSG00000127445 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl)
RIPK1GeneProductENSG00000137275 (Ensembl)
RNF125GeneProductENSG00000101695 (Ensembl)
SIKE1GeneProductENSG00000052723 (Ensembl)
SNW1GeneProductENSG00000100603 (Ensembl)
Short dsRNARna
TANKGeneProductENSG00000136560 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
TBKBP1GeneProductENSG00000198933 (Ensembl)
TMEM173GeneProductENSG00000184584 (Ensembl)
TNFAProteinENSG00000232810 (Ensembl)
TRADDGeneProductENSG00000102871 (Ensembl)
TRAF2GeneProductENSG00000127191 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
TRIM25GeneProductENSG00000121060 (Ensembl)
Ub-mediated proteolysisPathwayWP183 (WikiPathways)
Viral RNARna

Annotated Interactions

No annotated interactions

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