IL-6 signaling pathway (Mus musculus)

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UbiquitinationLigandEndosomeProteins in a complex interactionDDMTMethylationERDDNucleusCYEnzyme complexDeubiquitinationInhibitionCY->NUD(Protein-Protein interaction)PMRecruitmentGODDCY->NUEndoplasmic reticulumComplex formationDECPlasma membraneActivationPalmitoylationDDDephosphorylationMolecule in the pathwayDemethylationPhosphorylationCY->NUCY->NUExtracellularDTranslocationAutophosphorylationNUReceptorCytoplasmGolgi apparatusDesumoylationGlycosylationEarly EndosomesAcetylationDSumoylationCY->NUDMolecular associationENMitochondrionGene SymbolReactions through unknown mechanisms/moleculesAccession Number: NetPath 18DeacetylationCY->NUControlDCY->ENProteolytic cleavagePpp2cbSos13222402P14RikHras1Map2k6JunVav1Mapk14Eif2aPpp2r5eStat1Ppp2r1aTcf1Ppp2r4Gsk3bBtkGab2Stat3Erbb2Stat1Ppp2r2bCd40Eif4ebp1Map3k4Ptk2bPtpn11CebpbNcoa1MAPTInpp5dMapk1Inppl1Stat1Ep300Mllt7Ppp2caCasp3Mapk14Ppp2r2cHspb1Tyk2Ppp2r5aAkt1Eif4eStat1ArLynHdac1Stat3Il6stIl6raBmxStat5aFosPpp2r2aStat3Map2k4Jak1Map2k2Nfkb1Ppp2r5bIl6raRb1HckNfkb1Rac1Mapk8Shc1Foxo3aIl6Erbb3CrebbpStat5bCasp9Foxo1SgkStat3NlkBadPpp2r5dDaxxPlcg1FgrPtk2Il6stMap2k1SgkMapk3FesGab1Grb2Stat3TecPik3r2Ppp2r1bSocs3Il6Cdk5r1Stat3PrkcdPIK3R1Rps6ka2Mapkapk2Ppp2r5cMap3k7PxnRPS6KB1Raf1Map3k7Stat3Jak2Stat3Cdk9CebpbHsp90aa1FynCdk5


Description

No description

Comments

GenMAPP notes 
NetPath 18 - IL-6 signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
117906view10:32, 23 May 2021EweitzModified title
72091view21:32, 24 October 2013AlexanderPicoremoved PPP2R3B; no mouse homolog
71723view20:16, 17 October 2013MaintBotAutomated update of data sources
69096view18:11, 8 July 2013MaintBotUpdated to 2013 gpml schema
67385view10:45, 26 June 2013Christine ChichesterOntology Term : 'interleukin-6 signaling pathway' added !
41281view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
34384view22:48, 9 December 2009MaintBotAutomatic update of empty xrefs
28137view20:06, 27 January 2009KhanspersChanged name
21492view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:IL-6 NetPath 18]] moved to [[Pathway:WP387]]: Moved to stable identifier
8190view13:46, 7 January 2008MaintBot[[Pathway:Mouse:IL-6 NetPath 18]] moved to [[Pathway:Mus musculus:IL-6 NetPath 18]]: Renaming species
7715view16:12, 18 December 2007MaintBotfixed category names
7254view12:41, 4 November 2007MaintBotAdded categories to GPML
6463view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:IL-6_NetPath_18]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3222402P14RikGeneProduct235542 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
ArGeneProduct11835 (Entrez Gene)
BadGeneProduct12015 (Entrez Gene)
BmxGeneProduct12169 (Entrez Gene)
BtkGeneProduct12229 (Entrez Gene)
Casp3GeneProduct12367 (Entrez Gene)
Casp9GeneProduct12371 (Entrez Gene)
Cd40GeneProduct21939 (Entrez Gene)
Cdk5GeneProduct12568 (Entrez Gene)
Cdk5r1GeneProduct12569 (Entrez Gene)
Cdk9GeneProduct107951 (Entrez Gene)
CebpbGeneProduct12608 (Entrez Gene)
CrebbpGeneProduct12914 (Entrez Gene)
DaxxGeneProduct13163 (Entrez Gene)
Eif2aGeneProduct229317 (Entrez Gene)
Eif4eGeneProduct13684 (Entrez Gene)
Eif4ebp1GeneProduct13685 (Entrez Gene)
Ep300GeneProduct328572 (Entrez Gene)
Erbb2GeneProduct13866 (Entrez Gene)
Erbb3GeneProduct13867 (Entrez Gene)
FesGeneProduct14159 (Entrez Gene)
FgrGeneProduct14191 (Entrez Gene)
FosGeneProduct14281 (Entrez Gene)
Foxo1GeneProduct56458 (Entrez Gene)
Foxo3aGeneProduct56484 (Entrez Gene)
FynGeneProduct14360 (Entrez Gene)
Gab1GeneProduct14388 (Entrez Gene)
Gab2GeneProduct14389 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
HckGeneProduct15162 (Entrez Gene)
Hdac1GeneProduct433759 (Entrez Gene)
Hras1GeneProduct15461 (Entrez Gene)
Hsp90aa1GeneProduct15519 (Entrez Gene)
Hspb1GeneProduct15507 (Entrez Gene)
Il6GeneProduct16193 (Entrez Gene)
Il6raGeneProduct16194 (Entrez Gene)
Il6stGeneProduct16195 (Entrez Gene)
Inpp5dGeneProduct16331 (Entrez Gene)
Inppl1GeneProduct16332 (Entrez Gene)
Jak1GeneProduct16451 (Entrez Gene)
Jak2GeneProduct16452 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
LynGeneProduct17096 (Entrez Gene)
MAPTGeneProduct17762 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Map2k4GeneProduct26398 (Entrez Gene)
Map2k6GeneProduct26399 (Entrez Gene)
Map3k4GeneProduct26407 (Entrez Gene)
Map3k7GeneProduct26409 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk14GeneProduct26416 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
Mapkapk2GeneProduct17164 (Entrez Gene)
Mllt7GeneProduct54601 (Entrez Gene)
Ncoa1GeneProduct17977 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
NlkGeneProduct18099 (Entrez Gene)
PIK3R1GeneProduct18708 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Plcg1GeneProduct18803 (Entrez Gene)
Ppp2caGeneProduct19052 (Entrez Gene)
Ppp2cbGeneProduct19053 (Entrez Gene)
Ppp2r1aGeneProduct51792 (Entrez Gene)
Ppp2r1bGeneProduct73699 (Entrez Gene)
Ppp2r2aGeneProduct71978 (Entrez Gene)
Ppp2r2bGeneProduct72930 (Entrez Gene)
Ppp2r2cGeneProduct269643 (Entrez Gene)
Ppp2r4GeneProduct110854 (Entrez Gene)
Ppp2r5aGeneProduct226849 (Entrez Gene)
Ppp2r5bGeneProduct225849 (Entrez Gene)
Ppp2r5cGeneProduct26931 (Entrez Gene)
Ppp2r5dGeneProduct21770 (Entrez Gene)
Ppp2r5eGeneProduct26932 (Entrez Gene)
PrkcdGeneProduct18753 (Entrez Gene)
Ptk2GeneProduct14083 (Entrez Gene)
Ptk2bGeneProduct19229 (Entrez Gene)
Ptpn11GeneProduct19247 (Entrez Gene)
PxnGeneProduct19303 (Entrez Gene)
RPS6KB1GeneProduct72508 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
Rb1GeneProduct19645 (Entrez Gene)
Rps6ka2GeneProduct20112 (Entrez Gene)
SgkGeneProduct20393 (Entrez Gene)
Shc1GeneProduct20416 (Entrez Gene)
Socs3GeneProduct12702 (Entrez Gene)
Sos1GeneProduct20662 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Stat5aGeneProduct20850 (Entrez Gene)
Stat5bGeneProduct20851 (Entrez Gene)
Tcf1GeneProduct21405 (Entrez Gene)
TecGeneProduct21682 (Entrez Gene)
Tyk2GeneProduct54721 (Entrez Gene)
Vav1GeneProduct22324 (Entrez Gene)

Annotated Interactions

No annotated interactions
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