Hexoses metabolism in proximal tubules (Rattus norvegicus)
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Description
The role of glucose, fructose and the citric acid cycle in lipid synthesis in proximal tubules.
Quality Tags
Ontology Terms
Bibliography
- Fukuzawa T, Fukazawa M, Ueda O, Shimada H, Kito A, Kakefuda M, Kawase Y, Wada NA, Goto C, Fukushima N, Jishage K, Honda K, King GL, Kawabe Y; ''SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose.''; PLoS One, 2013 PubMed Europe PMC Scholia
- Tazawa S, Yamato T, Fujikura H, Hiratochi M, Itoh F, Tomae M, Takemura Y, Maruyama H, Sugiyama T, Wakamatsu A, Isogai T, Isaji M; ''SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose.''; Life Sci., 2005 PubMed Europe PMC Scholia
- Gonzalez-Vicente A, Garvin JL, Hopfer U; ''Transcriptome signature for dietary fructose-specific changes in rat renal cortex: A quantitative approach to physiological relevance.''; PLoS One, 2018 PubMed Europe PMC Scholia
- Grempler R, Augustin R, Froehner S, Hildebrandt T, Simon E, Mark M, Eickelmann P; ''Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter''; FEBS Lett., 2012 PubMed Europe PMC Scholia
- Gonzalez-Vicente A, Cabral PD, Hong NJ, Asirwatham J, Saez F, Garvin JL; ''Fructose reabsorption by rat proximal tubules: role of Na+-linked cotransporters and the effect of dietary fructose.''; Am J Physiol Renal Physiol, 2019 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
1,3BP-Glycerate | Metabolite | HMDB0001270 (HMDB) ![]() | |
2P-Glycerate | Metabolite | HMDB0000362 (HMDB) ![]() | |
3P-Glycerate | Metabolite | HMDB0000807 (HMDB) ![]() | |
Acetyl-CoA | Metabolite | 72-89-9 (CAS) ![]() | |
Acly | GeneProduct | 24159 (Entrez Gene) ![]() | |
Akr1b1 | GeneProduct | 24192 (Entrez Gene) ![]() | |
Aldoa | GeneProduct | 24189 (Entrez Gene) ![]() | |
Aldob | GeneProduct | 24190 (Entrez Gene) ![]() | |
Aldoc | GeneProduct | 24191 (Entrez Gene) ![]() | |
Aspartate | Metabolite | 6915-15-7 (CAS) ![]() | |
Citrate | Metabolite | 6915-15-7 (CAS) ![]() | |
Cs | GeneProduct | 170587 (Entrez Gene) ![]() | |
Diacylglycerol Synthesis | Pathway | ||
Dihydroxyacetone-P | Metabolite | HMDB0001473 (HMDB) ![]() | |
Dlat | GeneProduct | 81654 (Entrez Gene) ![]() | |
Dld | GeneProduct | 298942 (Entrez Gene) ![]() | |
Eno1 | GeneProduct | 24333 (Entrez Gene) ![]() | |
Eno2 | GeneProduct | 24334 (Entrez Gene) ![]() | |
Eno3 | GeneProduct | 25438 (Entrez Gene) ![]() | |
Fatty Acid Synthesis | Pathway | WP504 | |
Fbp1 | Protein | 24362 (Entrez Gene) ![]() | |
Fructose 6P | Metabolite | HMDB0000124 (HMDB) ![]() | |
Fructose-1,6BP | Metabolite | HMDB0001058 (HMDB) ![]() | |
Fructose-1-P | Metabolite | HMDB0001076 (HMDB) ![]() | |
Fructose | Metabolite | HMDB0000660 (HMDB) ![]() | |
G6pc | GeneProduct | 25634 (Entrez Gene) ![]() | |
Gapdh | GeneProduct | 24383 (Entrez Gene) ![]() | |
Glucose-6P | Metabolite | HMDB0001401 (HMDB) ![]() | |
Glucose | Metabolite | HMDB0000122 (HMDB) ![]() | |
Glyceraldehyde 3P | Metabolite | HMDB0001112 (HMDB) ![]() | |
Glycogen Metabolism | Pathway | ||
Glyderaldehyde | Metabolite | HMDB0001051 (HMDB) ![]() | |
Got1 | GeneProduct | 24401 (Entrez Gene) ![]() | |
Got2 | GeneProduct | 25721 (Entrez Gene) ![]() | |
Gpi | GeneProduct | 292804 (Entrez Gene) ![]() | |
Hk1 | GeneProduct | 25058 (Entrez Gene) ![]() | |
Khk | GeneProduct | 25659 (Entrez Gene) ![]() | |
Lactate | Metabolite | 79-33-4 (CAS) ![]() | |
Ldha | GeneProduct | 24533 (Entrez Gene) ![]() | Make sure to differentiate between M1 and M2 isoform |
Ldhb | GeneProduct | 24534 (Entrez Gene) ![]() | 2 Isoforms: L Liver and R red cells |
Malate | Metabolite | 6915-15-7 (CAS) ![]() | |
Mdh1 | GeneProduct | 24551 (Entrez Gene) ![]() | |
Mdh2 | GeneProduct | 81829 (Entrez Gene) ![]() | |
Mpc1 | GeneProduct | 171087 (Entrez Gene) ![]() | |
Neutral lipid
Synthesis Lipid Droplets | Pathway | ||
Oxalacetate | Metabolite | HMDB0000223 (HMDB) ![]() | |
P-enolpyruvate | Metabolite | HMDB0000263 (HMDB) ![]() | |
Pc | GeneProduct | 25104 (Entrez Gene) ![]() | |
Pck1 | GeneProduct | 362282 (Entrez Gene) ![]() | |
Pdha1 | GeneProduct | 29554 (Entrez Gene) ![]() | |
Pdha2 | GeneProduct | 117098 (Entrez Gene) ![]() | |
Pdhb | GeneProduct | 289950 (Entrez Gene) ![]() | |
Pdhx | GeneProduct | 311254 (Entrez Gene) ![]() | |
Pdk1 | GeneProduct | 116551 (Entrez Gene) ![]() | |
Pdk2 | GeneProduct | 81530 (Entrez Gene) ![]() | |
Pdk3 | GeneProduct | 296849 (Entrez Gene) ![]() | |
Pdk4 | GeneProduct | 89813 (Entrez Gene) ![]() | |
Pdp1 | GeneProduct | 54705 (Entrez Gene) ![]() | |
Pdp2 | GeneProduct | 246311 (Entrez Gene) ![]() | |
Pentose Phosphate Pathway | Pathway | ||
Pfkl | GeneProduct | 25741 (Entrez Gene) ![]() | |
Pfkm | GeneProduct | 65152 (Entrez Gene) ![]() | |
Pfkp | GeneProduct | 60416 (Entrez Gene) ![]() | |
Pgam1 | GeneProduct | 24642 (Entrez Gene) ![]() | |
Pgam2 | GeneProduct | 24959 (Entrez Gene) ![]() | |
Pgk1 | GeneProduct | 24644 (Entrez Gene) ![]() | |
Pgk2 | GeneProduct | 316265 (Entrez Gene) ![]() | |
Pklr | GeneProduct | 24651 (Entrez Gene) ![]() | Make sure to differentiate between M1 and M2 isoform |
Pkm | GeneProduct | 25630 (Entrez Gene) ![]() | 2 Isoforms: L Liver and R red cells |
Pyruvate | Metabolite | HMDB0000243 (HMDB) ![]() | |
Slc2a2 | GeneProduct | 25351 (Entrez Gene) ![]() | |
Slc2a5 | GeneProduct | 65197 (Entrez Gene) ![]() | |
Slc5a10 | GeneProduct | 303205 (Entrez Gene) ![]() | |
Slc5a1 | GeneProduct | 25552 (Entrez Gene) ![]() | |
Slc5a2 | GeneProduct | 64522 (Entrez Gene) ![]() | |
Slc5a9 | GeneProduct | 366441 (Entrez Gene) ![]() | |
Sorbitol | Metabolite | HMDB0000247 (HMDB) ![]() | |
Sord | GeneProduct | 24788 (Entrez Gene) ![]() | |
Tkfc | GeneProduct | 361730 (Entrez Gene) ![]() | |
Tpi1 | GeneProduct | 24849 (Entrez Gene) ![]() | |
mpc2 | GeneProduct | 100359982 (Entrez Gene) ![]() |
Annotated Interactions
No annotated interactions