miRNA regulation of p53 pathway in prostate cancer (Homo sapiens)

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1Cell cycleStress signalsgamma-radiationp53 negative feedbackUVGenotoxic drugsNutritiondeprivationHeat/Cold shockDNA damageDNATP53Nitric oxideCHEK2ATMROSMIR4482PPMIR548CMIR1305MIR548BMDM2SIAH1PTENP48SESN3SERPINE1ScotinEI24BAXTNFRSF10BMIR548CPMAIP1BBC3MIR1305CASP8MIR27BPERPZMAT3SIAH1MIR4491MIR548CMIR1305BIDMIR548BMIR27BMIR320AMIR182MIR4482MIR548CMIR19aMIR1305Inhibition of IGF-1/mTOR pathwayDNA repair anddamage preventionInhibition of angiogenesisand metastasisMIR27BMIR320AMIR548CMIR1305TP53AIP1CYS1APAF1MIR548CCASP9CASP3ApoptosisApoptosisHypoxia


Description

Diagrammatic scheme depicting targeted p53 pathway-related genes by upregulated miRNAs in prostate tumor cells. An integrated in silico and computational prediction databases (DIANA-micro T-CDS, miRBase, and TargetScan) were employed section to predict potential targets of a subset of highly upregulated miRNAs (>2-fold) in prostate tumors.

Note that some targeting miRNAs were removed from the original publication figure for clarity. These are represented in supplementary table S3: http://journals.sagepub.com/doi/suppl/10.1177/1535370216681554.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Bibliography

  1. Moustafa AA, Ziada M, Elshaikh A, Datta A, Kim H, Moroz K, Srivastav S, Thomas R, Silberstein JL, Moparty K, Salem FE, El-Habit OH, Abdel-Mageed AB; ''Identification of microRNA signature and potential pathway targets in prostate cancer.''; Exp Biol Med (Maywood), 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128740view04:50, 21 February 2024EweitzUpgrade disease node
108115view10:22, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106438view23:26, 28 August 2019KhanspersModified description
105493view05:48, 8 August 2019KhanspersModified description
96401view10:16, 12 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
94298view21:19, 31 August 2017KhanspersModified description
94296view21:18, 31 August 2017KhanspersModified description
94294view21:11, 31 August 2017Khanspers
92330view23:26, 23 May 2017Khanspersconnected interaction
92309view19:00, 19 May 2017KhanspersOntology Term : 'prostate cancer' added !
92308view19:00, 19 May 2017KhanspersModified description
92301view18:56, 19 May 2017KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
APAF1GeneProductENSG00000120868 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductENSG00000105327 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CHEK2GeneProductENSG00000183765 (Ensembl)
CYS1GeneProductENSG00000205795 (Ensembl)
DNAMetaboliteCHEBI:16991 (ChEBI)
EI24GeneProductENSG00000149547 (Ensembl)
HypoxiaQ105688 (Wikidata)
MDM2GeneProductENSG00000135679 (Ensembl)
MIR1305GeneProductENSG00000221227 (Ensembl)
MIR182GeneProductENSG00000207990 (Ensembl)
MIR19aGeneProductMIMAT0004490 (miRBase mature sequence) Annotated with MIMAT because BridegDb not yet up-to-date with latest from Entrez for this entity
MIR27BGeneProductENSG00000207864 (Ensembl)
MIR320AGeneProductENSG00000208037 (Ensembl)
MIR4482GeneProductENSG00000266852 (Ensembl)
MIR4491GeneProductENSG00000264032 (Ensembl)
MIR548BGeneProductENSG00000207982 (Ensembl)
MIR548CGeneProductENSG00000207546 (Ensembl)
Nitric oxideMetaboliteCHEBI:16480 (ChEBI)
P48GeneProductENSG00000134574 (Ensembl)
PERPGeneProductENSG00000112378 (Ensembl)
PMAIP1GeneProductENSG00000141682 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
ROSMetaboliteQ424361 (Wikidata)
SERPINE1GeneProductENSG00000106366 (Ensembl)
SESN3GeneProductENSG00000149212 (Ensembl)
SIAH1GeneProductENSG00000196470 (Ensembl)
ScotinGeneProductENSG00000164054 (Ensembl)
TNFRSF10BGeneProductENSG00000120889 (Ensembl)
TP53AIP1GeneProductENSG00000120471 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
ZMAT3GeneProductENSG00000172667 (Ensembl)

Annotated Interactions

No annotated interactions

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