Circulating monocytes and cardiac macrophages in diastolic dysfunction (Mus musculus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none MyofibroblastMacrophageEndothelial cellCollagen depositionLeft ventriculardiastolic dysfunctionBloodAutocrine activationDecreased proteases / MMPsIl10ROSCcl2MonocyteCcr2AdhesionmoleculesSpp1FibroblastROSROSIl10FibroblastactivationMyocardiumMonocyteName: Circulating monocytes and cardiac macrophages in diastolic dysfunctionOrganism: Mus musculus


Description

This pathway is modeled based on fig 10 in [Hulsmans et al](https://www.ncbi.nlm.nih.gov/pubmed/29339450), and was developed in collaboration with Dr. Matthias Nahrendorf. Circulating monocytes and myocardial macrophage density are increased in diastolic dysfunction, and the macrophage expansion is partially driven by monocyte recruitment. Mechanistically, cardiac macrophages produce more IL-10 leading to autocrine activation toward a fibrogenic phenotype. A profibrotic macrophage subset secretes more Spp1 (OPN) and fewer proteases and MMPs, contributing to fibroblast activation, collagen deposition, and subsequently increased myocardial stiffness and diastolic dysfunction. (Description based on figure 10 legend).

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Quality Tags

Image:Curated.pngApproved version
Image:Featured.pngReview changes for Featured

Ontology Terms

Bibliography

  1. Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M; ''Cardiac macrophages promote diastolic dysfunction.''; J Exp Med, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137929
Approved
view18:29, 10 March 2025KhanspersModified description
129333
Featured
view09:07, 27 March 2024MkutmonOntology Term : 'disease pathway' added !
102094view00:18, 29 November 2018KhanspersModified title
102093view00:14, 29 November 2018KhanspersModified description
102091view22:14, 28 November 2018KhanspersOntology Term : 'hypertension' added !
102090view22:14, 28 November 2018KhanspersOntology Term : 'myofibroblast cell' added !
102089view22:13, 28 November 2018KhanspersOntology Term : 'cardiovascular system disease' added !
102088view22:13, 28 November 2018KhanspersOntology Term : 'macrophage' added !
102087view22:13, 28 November 2018KhanspersOntology Term : 'monocyte' added !
102086view22:12, 28 November 2018KhanspersNew pathway

External references

DataNodes

Name  ↓Type  ↓Database reference  ↓Comment  ↓
Ccl2GeneProductENSMUSG00000035385 (Ensembl)
Ccr2GeneProductENSMUSG00000049103 (Ensembl)
Il10GeneProductENSMUSG00000016529 (Ensembl)
ROSMetaboliteCHEBI:26523 (ChEBI)
Spp1GeneProductENSMUSG00000029304 (Ensembl)

Annotated Interactions

No annotated interactions

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