Resistin as a regulator of inflammation (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Ca2+NucleusUnknown receptorDNACytosolIP3Calcium channelMAPK CascadeEndoplasmic reticulumIL6IL8TNFIL12BIL12AITP3Rp38RETNAKT1AKT2AKT3ERK1ERK2PLCB1PLCB2PLCB3PLCB4PLCG1PLCG2PLCD1PLCD4PLCD3PLCE1IkKAIkKBIkKGIkBARELANFKB1PI3KAPI3KBPI3KDPI3KGNFKB1RELAIkBANFKB1RELAPCa2+Ca2+Name: Resistin as a regulator of inflammationOrganism: Homo sapiens


Description

Resistin induced intracellular signaling pathways. No receptor for resistin has yet been identified. Resistin induces NF-kB activity. Resistin increases the cytosolic Ca concentration via both PLC activation, leading to the release of Ca from intracellular pools, such as the endoplasmic reticulum, and Ca influx from the extracellular environment. Activation of the abovementioned signaling pathways via resistin suggests that it has proinflammatory potential.

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Quality Tags

Image:Unconnected.pngFix interactions
Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

  1. Gilmore TD; ''Introduction to NF-kappaB: players, pathways, perspectives.''; Oncogene, 2006 PubMed Europe PMC Scholia
  2. Filková M, Haluzík M, Gay S, Senolt L; ''The role of resistin as a regulator of inflammation: Implications for various human pathologies.''; Clin Immunol, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
121702
Approved
view03:51, 26 February 2022EweitzFix gene symbol
102529view01:29, 4 January 2019Khanspersconnected interactions
102273view22:31, 16 December 2018AndraOntology Term : 'disease by infectious agent' added !
102272view22:30, 16 December 2018AndraOntology Term : 'altered regulatory pathway' added !
102271view22:28, 16 December 2018Andraconnected lines
102251view09:55, 13 December 2018LaurentModified description
102250view09:55, 13 December 2018LaurentModified description
102249view09:54, 13 December 2018LaurentNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
ERK1GeneProduct5595 (Entrez Gene)
ERK2GeneProduct5594 (Entrez Gene)
IL12AGeneProduct3592 (Entrez Gene)
IL12BGeneProduct3593 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct3576 (Entrez Gene)
ITP3RGeneProduct3708 (Entrez Gene)
IkBAGeneProduct4792 (Entrez Gene)
IkKAGeneProduct1147 (Entrez Gene)
IkKBGeneProduct3551 (Entrez Gene)
IkKGGeneProduct8517 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
PI3KAGeneProduct5290 (Entrez Gene)
PI3KBGeneProduct5291 (Entrez Gene)
PI3KDGeneProduct5293 (Entrez Gene)
PI3KGGeneProduct5294 (Entrez Gene)
PLCB1GeneProduct23236 (Entrez Gene)
PLCB2GeneProduct5330 (Entrez Gene)
PLCB3GeneProduct5331 (Entrez Gene)
PLCB4GeneProduct5332 (Entrez Gene)
PLCD1GeneProduct5333 (Entrez Gene)
PLCD3GeneProduct113026 (Entrez Gene)
PLCD4GeneProduct84812 (Entrez Gene)
PLCE1GeneProduct51196 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PLCG2GeneProduct5336 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RETNGeneProduct56729 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
p38GeneProduct1432 (Entrez Gene)

Annotated Interactions

No annotated interactions

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