Resistin as a regulator of inflammation (Homo sapiens)
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Description
Resistin induced intracellular signaling pathways. No receptor for resistin has yet been identified. Resistin induces NF-kB activity. Resistin increases the cytosolic Ca concentration via both PLC activation, leading to the release of Ca from intracellular pools, such as the endoplasmic reticulum, and Ca influx from the extracellular environment. Activation of the abovementioned signaling pathways via resistin suggests that it has proinflammatory potential.
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Ontology Terms
Saving...Pathway Ontology : disease pathway
Disease : congenital heart disease oculocerebrorenal syndrome male infertility juvenile myoclonic epilepsy Senior-Loken syndrome Pallister-Hall syndrome Bardet-Biedl syndrome sensorineural hearing loss Carpenter syndrome hydrolethalus syndrome cone-rod dystrophy asphyxiating thoracic dystrophy holoprosencephaly nephronophthisis orofaciodigital syndrome infertility ciliopathy retinitis pigmentosa Leber congenital amaurosis Greig cephalopolysyndactyly syndrome primary ciliary dyskinesia Meckel syndrome Ellis-Van Creveld syndrome medulloblastoma lethal congenital contracture syndrome Birt-Hogg-Dube syndrome polycystic kidney disease Joubert syndrome
Bibliography
- Gilmore TD; ''Introduction to NF-kappaB: players, pathways, perspectives.''; Oncogene, 2006 PubMed Europe PMC Scholia
- Filková M, HaluzÃk M, Gay S, Senolt L; ''The role of resistin as a regulator of inflammation: Implications for various human pathologies.''; Clin Immunol, 2009 PubMed Europe PMC Scholia
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