FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma (Homo sapiens)

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Diffuse large B-cell lymphoma1Histone H3Cell proliferationHistone H2APRC2 complexHistone H2AH2AFB1Histone H3H2AFB2MAP/ERK signalingUbMeMAPK1MAPK3DUSP6MAPK1MAPK3EEDEZH2SUZ12PCGF1BCORFBXL10BCL6DUSP6RNF2Non-canonical PRC1 complexH3F3AH3F3BHIST1H3DHIST1H3JHIST2H3AHIST2H3CHIST2H3DHIST1H3CHIST1H3GHIST1H3HHIST1H3AHIST1H3FHIST1H3BHIST1H3IHIST1H3EH2AFB3H2AFJH2AFVH2AFXH2AFYH2AFY2H2AFZ


Description

FBXL10, a member of Polycomb repressive complexes, is overexpressed in human diffuse large B-cell lymphoma tissues and cell lines. FBXL10 silences the expression of DUSP6 through recruitment of polycomb repressuive complexes, which leads to the deposition of repressive histone modifications in the DUPS6 promoter. DUSP6 is a ERK1/2 (MAPK1/MAPK3) phosphatase and with lower levels of DUSP6, ERK1/2 remain phosphorylated and thus activates downstream ERK/MAPK signaling and ultimately cell proliferation.

Based on figure 7 in Zhao et al

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Bibliography

  1. Zhao X, Wang X, Li Q, Chen W, Zhang N, Kong Y, Lv J, Cao L, Lin D, Xu G, Wu X; ''FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway.''; Cell Death Dis, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134687view00:09, 26 July 2024EweitzFix, match histone labels in condensed and expanded nodes
134686view00:06, 26 July 2024EweitzEconomize layout
134685view21:59, 25 July 2024EweitzStandardize case
134684view21:58, 25 July 2024EweitzEconomize layout
129526view01:14, 9 May 2024EweitzOntology Term : 'B cell' added !
103606view22:05, 20 March 2019KhanspersModified title
103605view22:05, 20 March 2019KhanspersModified title
103593view19:19, 19 March 2019KhanspersOntology Term : 'disease of cellular proliferation' added !
103592view19:18, 19 March 2019KhanspersModified description
103591view19:17, 19 March 2019KhanspersOntology Term : 'altered extracellular signal-regulated Raf/Mek/Erk signaling pathway' added !
103590view19:17, 19 March 2019KhanspersOntology Term : 'diffuse large B-cell lymphoma' added !
103589view19:16, 19 March 2019KhanspersModified description
103588view19:14, 19 March 2019KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BCL6GeneProductENSG00000113916 (Ensembl)
BCORGeneProductENSG00000183337 (Ensembl)
DUSP6GeneProductENSG00000139318 (Ensembl)
EEDGeneProductENSG00000074266 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FBXL10GeneProductENSG00000089094 (Ensembl)
H2AFB1GeneProductENSG00000274183 (Ensembl)
H2AFB2GeneProductENSG00000277858 (Ensembl)
H2AFB3GeneProductENSG00000277745 (Ensembl)
H2AFJGeneProductENSG00000246705 (Ensembl)
H2AFVGeneProductENSG00000105968 (Ensembl)
H2AFXGeneProductENSG00000188486 (Ensembl)
H2AFY2GeneProductENSG00000099284 (Ensembl)
H2AFYGeneProductENSG00000113648 (Ensembl)
H2AFZGeneProductENSG00000164032 (Ensembl)
H3F3AGeneProductENSG00000163041 (Ensembl)
H3F3BGeneProductENSG00000132475 (Ensembl)
HIST1H3AGeneProductENSG00000275714 (Ensembl)
HIST1H3BGeneProductENSG00000274267 (Ensembl)
HIST1H3CGeneProductENSG00000278272 (Ensembl)
HIST1H3DGeneProductENSG00000197409 (Ensembl)
HIST1H3EGeneProductENSG00000274750 (Ensembl)
HIST1H3FGeneProductENSG00000277775 (Ensembl)
HIST1H3GGeneProductENSG00000273983 (Ensembl)
HIST1H3HGeneProductENSG00000278828 (Ensembl)
HIST1H3IGeneProductENSG00000275379 (Ensembl)
HIST1H3JGeneProductENSG00000197153 (Ensembl)
HIST2H3AGeneProductENSG00000203852 (Ensembl)
HIST2H3CGeneProductENSG00000203811 (Ensembl)
HIST2H3DGeneProductENSG00000183598 (Ensembl)
Histone H2AGeneProduct
Histone H3GeneProduct
MAP/ERK signalingPathway
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
PCGF1GeneProductENSG00000115289 (Ensembl)
RNF2GeneProductENSG00000121481 (Ensembl)
SUZ12GeneProductENSG00000178691 (Ensembl)

Annotated Interactions

No annotated interactions

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