MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement (Homo sapiens)
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Description
Proposed signaling pathways by which MFAP5 induces LPP expression and increases the permeability and motility of endothelial cells via cytoskeleton rearrangement.
The activation of the MFAP5-mediated signaling cascade in endothelial cells up-regulates LPP expression and subsequently promotes the motility of endothelial cells and the permeability of the endothelial cell monolayer.
Adapted from supplemental figure 11 from Leung et al.Quality Tags
Ontology Terms
Bibliography
- Leung CS, Yeung TL, Yip KP, Wong KK, Ho SY, Mangala LS, Sood AK, Lopez-Berestein G, Sheng J, Wong ST, Birrer MJ, Mok SC; ''Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance.''; J Clin Invest, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ACTN1 | GeneProduct | ENSG00000072110 (Ensembl) ![]() | |
CREB1 | GeneProduct | ENSG00000118260 (Ensembl) ![]() | |
Ca2+ | Metabolite | CHEBI:29108 (ChEBI) ![]() | |
Calcium channel | GeneProduct | ||
ITGAV | GeneProduct | ENSG00000138448 (Ensembl) ![]() | |
ITGB3 | GeneProduct | ENSG00000259207 (Ensembl) ![]() | |
ITPR1 | GeneProduct | ENSG00000150995 (Ensembl) ![]() | |
JUN | GeneProduct | ENSG00000177606 (Ensembl) ![]() | |
LPP | GeneProduct | ENSG00000145012 (Ensembl) ![]() | |
MAPK1 | GeneProduct | ENSG00000100030 (Ensembl) ![]() | |
MAPK3 | GeneProduct | ENSG00000102882 (Ensembl) ![]() | |
MFAP5 | GeneProduct | ENSG00000197614 (Ensembl) ![]() | |
MYL2 | GeneProduct | ENSG00000111245 (Ensembl) ![]() | |
MYLK | GeneProduct | ENSG00000065534 (Ensembl) ![]() | |
PLCG1 | GeneProduct | ENSG00000124181 (Ensembl) ![]() | |
PRKCQ | GeneProduct | ENSG00000065675 (Ensembl) ![]() | |
PTK2 | GeneProduct | ENSG00000169398 (Ensembl) ![]() | |
PXN | GeneProduct | ENSG00000089159 (Ensembl) ![]() | |
TJP1 | GeneProduct | ENSG00000104067 (Ensembl) ![]() | |
VCL | GeneProduct | ENSG00000035403 (Ensembl) ![]() |
Annotated Interactions
No annotated interactions