Canonical NF-kB pathway (Homo sapiens)
From WikiPathways
Description
The canonical NF-KB pathway is induced by the ligand-dependent activation of a variety of receptors. Stimulus-dependent activation of the IKK complex results in the phosphorylation and subsequent proteasomal degradation of IκBα and IκBε (NFKBIA and NFKBIE). This allows the nuclear translocation of transcriptionally active RelA/p50 (RELA, NFKB1) or c-Rel/p50 heterodimers (REL, NFKB1).
Quality Tags
 | Open Access |
 | Approved version |
 |  |
Ontology Terms
Saving...Pathway Ontology : calcium/calmodulin dependent signaling pathway G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphas family Ras superfamily mediated signaling pathway G protein mediated signaling pathway via Galphaq family endothelin signaling pathway
Disease : hypertension benign essential hypertension
Cell Type : smooth muscle cell blood vessel endothelial cell
Bibliography
- Grondona P, Bucher P, Schulze-OsthoffK, Hailfinger S, Schmitt A; ''NF-κB Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy.''; Biomedicines, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
Name  | Type | Database reference | Comment |
|---|---|---|---|
| CHUK | GeneProduct | ENSG00000213341 (Ensembl)  | IKKa |
| IKBKB | GeneProduct | ENSG00000104365 (Ensembl) | |
| IKBKG | GeneProduct | ENSG00000269335 (Ensembl) | IKKy |
| NFKB1 | GeneProduct | ENSG00000109320 (Ensembl) | |
| NFKBIA | GeneProduct | ENSG00000100906 (Ensembl) | |
| NFKBIE | GeneProduct | ENSG00000146232 (Ensembl) | |
| RELA | GeneProduct | ENSG00000173039 (Ensembl) | RelA |
| REL | GeneProduct | ENSG00000162924 (Ensembl) | c-Rel |
Annotated Interactions
No annotated interactions
