Purinergic signaling (Homo sapiens)

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3, 10, 1275Gi/oprotein familyG protein couplingLegendP1 or Adenosine receptorsAgonist bindingcAMP up due to ADORA1->Bronchoconstriction->Afferent arteriolar constriction in Kidney-> decreased heart ratePro-InflammationADORA1stimulatescations in generalcAMP down due to ADORA3->Cardiac muscle relaxation->Smooth muscle contraction->Cardioprotective in cardiac ischemia->Inhibition of neutrophil degranulationPhysiological downstream effects in target tissuechannel permeability for:via cGMP and Adenylyl cyclasecAMP up due to ADORA2A->Coronary artery vasodilatation->Decreased dopaminergic activity in CNS->Inhibition of central neuron excitation.P2RY8ADPLPAR4P2RY12AMPGNAZLUF-5835SDZ WAG 994PSB 36IstradefyllineP2RY2CVT-6883P2RX1MRS-1706ADORA2BP2RX2UTP5'-N-ethylcarboxamidoadenosineGR 79236ATPCCPABAY 60–6583MRS-1334ZM-241,385PSB 10P2RX3AdenosineP2RY13ADORA3P2RX4PSB-0788P2RX5MRE3008F20PANX1CPX2'-MeCCPAGNAO1MRS-1754SCH-442,416LPAR6LPAcAMP2-Cl-IB-MECAN6-CyclopentyladenosineUDP-glucoseRegadenosonPSB-11ATL-146eP2RX7MRS-3558CaffeineP2RY4ADORA1GNAI1PSB-1115P2RY6ADORA2A8-Phenyl-1,3-dipropylxanthineN6-3-methoxyl-4-hydroxybenzyl adenine ribosideUDPMRS-1220P2RY14DPCPXN-methyl-D-glucamineP2RY11PSB-603MRS-1523GNAT1GNAT3P2RX6LUF-5845P2RY10MRS-3777VUF-5574HEMADOGq/11IB-MECACP-532,903P2RY1GNAT2SCH-58261CGS-21680GNAI3TheophyllineMRS-1191P2Y groupP2X groupligand gated ion channels22016188720151761320207721195GiGNASBLU-59379, 11GefapixantOpiranserin1Ivermectin5Zn(2+)SuraminPPADS 55L-Glutathione4, 14Ca(2+)5Mg(2+)Cu(2+)5GNAI25cAMP up due to ADORA2B ->Bronchoconstriction->BronchospasmADORA3inhibitsCa(2+)Antagonist binding


Description

Purinergic signaling is involved in several processes including neurologic, endocrine, and immune system signaling.

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Ontology Terms

 

Bibliography

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  1. Richards D, Gever JR, Ford AP, Fountain SJ; ''Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation.''; Br J Pharmacol, 2019 PubMed Europe PMC Scholia
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  13. Baraldi PG, Tabrizi MA, Fruttarolo F, Romagnoli R, Preti D; ''Recent improvements in the development of A(2B) adenosine receptor agonists.''; Purinergic Signal, 2008 PubMed Europe PMC Scholia
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  15. Zocchi C, Ongini E, Conti A, Monopoli A, Negretti A, Baraldi PG, Dionisotti S; ''The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist.''; J Pharmacol Exp Ther, 1996 PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
134667view14:44, 25 July 2024Ash iyeradded missing annotation to datanodes.
134647view08:58, 24 July 2024EgonwRemoved la
134630view11:21, 23 July 2024EweitzMove legend to corner
134629view11:20, 23 July 2024EweitzRefine legend
134628view11:15, 23 July 2024EweitzModified description
123440view04:49, 27 July 2022EgonwCID of the active ingredient
110333view06:41, 6 May 2020FehrhartOntology Term : 'nucleoside and nucleotide mediated signaling pathway' added !
110280view07:15, 2 May 2020EgonwRemoved whitespace from PubChem identifiers.
110275view07:02, 2 May 2020EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
110157view06:34, 22 April 2020FehrhartWork in progress
110126view10:32, 19 April 2020FehrhartWork in progress
110125view10:18, 19 April 2020FehrhartWork in progress
110112view15:26, 17 April 2020FehrhartWork in progress
110110view10:47, 17 April 2020FehrhartOntology Term : 'nucleotide signaling via the purinergic P2Y receptors.' added !
110109view09:43, 17 April 2020FehrhartWork in progress
110108view09:33, 17 April 2020FehrhartNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
2'-MeCCPAMetabolite122173097 (PubChem-compound)
2-Cl-IB-MECAMetabolite3035850 (PubChem-compound)
5'-N-ethylcarboxamidoadenosineMetabolite3086599 (PubChem-compound)
8-Phenyl-1,3-dipropylxanthineMetabolite90477827 (PubChem-compound)
ADORA1GeneProductENSG00000163485 (Ensembl)
ADORA2AGeneProductENSG00000128271 (Ensembl)
ADORA2BGeneProductENSG00000170425 (Ensembl)
ADORA3GeneProductENSG00000282608 (Ensembl)
ADPMetabolite16761  (ChEBI)
AMPMetabolite16027 (ChEBI)
ATL-146eMetabolite9805430 (PubChem-compound)
ATPMetabolite15422 (ChEBI)
AdenosineMetabolite16335 (ChEBI)
BAY 60–6583Metabolite11717831 (PubChem-compound)
BLU-5937Metabolite
CCPAMetabolite123807 (PubChem-compound)
CGS-21680Metabolite3086599 (PubChem-compound)
CP-532,903Metabolite10479002 (PubChem-compound)
CPXMetabolite1917 (PubChem-compound) 8-Cyclopentyl-1,3-dimethylxanthine
CVT-6883Metabolite11270783 (PubChem-compound)
Ca(2+)MetaboliteCHEBI:29108 (ChEBI)
CaffeineMetabolite27732 (ChEBI)
Cu(2+)MetaboliteCHEBI:29036 (ChEBI)
DPCPXMetabolite73282 (ChEBI) 8-Cyclopentyl-1,3-dipropylxanthine
GNAI1GeneProductENSG00000127955 (Ensembl)
GNAI2GeneProductENSG00000114353 (Ensembl)
GNAI3GeneProductENSG00000065135 (Ensembl)
GNAO1GeneProductENSG00000087258 (Ensembl)
GNASGeneProductENSG00000087460 (Ensembl) Gs alpha subunit (also Gαs, Gsα)
GNAT1GeneProductENSG00000114349 (Ensembl)
GNAT2GeneProductENSG00000134183 (Ensembl)
GNAT3GeneProductENSG00000214415 (Ensembl)
GNAZGeneProductENSG00000128266 (Ensembl)
GR 79236Metabolite9884817 (PubChem-compound)
GefapixantMetabolite24764487 (PubChem-compound)
GiGeneProduct2770 (Entrez Gene)
Gq/11GeneProduct2767 (Entrez Gene)
HEMADOMetabolite10981286 (PubChem-compound) 2-(1-Hexynyl)-N-methyladenosine
IB-MECAMetabolite123683 (PubChem-compound) CF-101
IstradefyllineMetabolite5311037 (PubChem-compound)
IvermectinMetabolite9812710 (PubChem-compound)
L-GlutathioneMetaboliteCHEBI:16856 (ChEBI)
LPAMetabolite132742 (ChEBI) Lysophosphatidic acid
LPAR4GeneProductENSG00000147145 (Ensembl)
  • P2RY9
  • GPR23
LPAR6GeneProductENSG00000139679 (Ensembl)
LUF-5835Metabolite
LUF-5845Metabolite
MRE3008F20Metabolite5310960 (PubChem-compound)
MRS-1191Metabolite393594 (PubChem-compound)
MRS-1220Metabolite393595 (PubChem-compound)
MRS-1334Metabolite10324445 (PubChem-compound)
MRS-1523Metabolite3661570 (PubChem-compound)
MRS-1706Metabolite5139184 (PubChem-compound)
MRS-1754Metabolite6603931 (PubChem-compound)
MRS-3558Metabolite11248240 (PubChem-compound)
MRS-3777Metabolite11771279 (PubChem-compound)
Mg(2+)MetaboliteCHEBI:18420 (ChEBI)
N-methyl-D-glucamineMetaboliteCHEBI:59732 (ChEBI)
N6-3-methoxyl-4-hydroxybenzyl adenine ribosideMetaboliteB2
N6-CyclopentyladenosineMetabolite657378 (PubChem-compound)
OpiranserinMetabolite71566778 (PubChem-compound)
P2RX1GeneProductENSG00000108405 (Ensembl)
P2RX2GeneProductENSG00000187848 (Ensembl)
P2RX3GeneProductENSG00000109991 (Ensembl)
P2RX4GeneProductENSG00000135124 (Ensembl)
P2RX5GeneProductENSG00000083454 (Ensembl)
P2RX6GeneProductENSG00000099957 (Ensembl)
P2RX7GeneProductENSG00000089041 (Ensembl)
P2RY10GeneProductENSG00000078589 (Ensembl)
P2RY11GeneProductENSG00000244165 (Ensembl)
P2RY12GeneProductENSG00000169313 (Ensembl)
P2RY13GeneProductENSG00000181631 (Ensembl)
P2RY14GeneProductENSG00000174944 (Ensembl)
P2RY1GeneProductENSG00000169860 (Ensembl)
P2RY2GeneProductENSG00000175591 (Ensembl)
P2RY4GeneProductENSG00000186912 (Ensembl)
P2RY6GeneProductENSG00000171631 (Ensembl)
P2RY8GeneProductENSG00000182162 (Ensembl)
PANX1GeneProductENSG00000110218 (Ensembl)
PPADS Metabolite6093163 (PubChem-compound) pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid
PSB 10Metabolite10318703 (PubChem-compound)
PSB 36Metabolite9864310 (Chemspider)
  • 1-butyl-8-(3- noradamantyl)-3-(3-hydroxypropyl)xanthine
  • 1-Butyl-3-(3-hydroxypropyl)-8-(tricyclo[3.3.1.03,7]non-3-yl)-3,7-dihydro-1H-purine-2,6-dione
PSB-0788Metabolite44186581 (PubChem-compound)
PSB-11Metabolite
PSB-1115Metabolite5311479 (PubChem-compound)
PSB-603Metabolite
RegadenosonMetabolite219024 (PubChem-compound)
SCH-442,416Metabolite10668061 (PubChem-compound)
SCH-58261Metabolite176408 (PubChem-compound)
SDZ WAG 994Metabolite18755269 (PubChem-compound)
SuraminMetabolite5361 (PubChem-compound)
TheophyllineMetabolite28177 (ChEBI)
UDP-glucoseMetabolite46229 (ChEBI)
UDPMetabolite58223 (ChEBI)
UTPMetabolite15713 (ChEBI)
VUF-5574Metabolite4046493 (PubChem-compound)
ZM-241,385Metabolite176407 (PubChem-compound)
Zn(2+)MetaboliteCHEBI:29105 (ChEBI)
cAMPMetaboliteCHEBI:17489 (ChEBI)

Annotated Interactions

No annotated interactions

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