Peptidoglycan cytoplasmic synthesis and recycling pathways (Escherichia coli)

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1, 2additional periplasmic enzymes (degradation)L-Ala-gamma-D-Glu-meso-DAP-D-AlaglmSmurFTonB-dependent uptake?D-AlaglmUglmManhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-AlaglutaminePeriplasmExtracellular SpaceCytoplasmD-glucosamine-6-phosphateUDP-MurNAc-L-AlaL-glutamateD-Ala-D-AlaDiaminopimelic acidPenicillin-binding protein 1CL-alaninePenicillin-binding protein 1BUndecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineUTPD-alanineUndecaprenyl phosphateGlucosamine-1PUND-PP-MurNAc-L-Ala-D-Glu-meso-DAP-D-Ala-D-AlaUDP-MurNAc-L-Ala-D-GluUndecaprenyl pyrophosphateFructose-6-phosphateD-glutamateUDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAPUDP-GlcNAcUDP-MurNAcUndecaprenyl-diphosphataseUDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-AlaPenicillin-binding protein 1AphosphoenolpyruvateUDP-GlcNAc-enolpyruvateNADPHN-acetylglucosamine-1-phosphatePeptidoglycan LayerAcetyl-CoAL-alanineGlcNAc-6-PMurNAc 6-phosphateGlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-AlaMurNAcPenicillin-binding protein 2(Peptidoglycan D,D-transpeptidase MrdA}Penicillin-binding protein 3(Peptidoglycan D,D-transpeptidase FtsI)glmUmurEmurDmurCmurBmurAmurGmraYddlBdadXalrmurIampGmplmurJftsWmtgAmurPanmKmurQnagAnagBnagK1,6-anhMurNAcGlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-AlanagZGlcNAc1,6-anhydro-N-acetylmuramyl-L-alanine amidase (AmpD)L-Ala-gamma-D-Glu-meso-DAPMurein tetrapeptide carboxypeptidase (LdcA)additional periplasmic enzymes (synthesis)


Description

PG cytoplasmic synthesis and recycling pathways in E. coli

Comments

 
NOTE: Cytoplasmic pathways only. Membrane & periplasmic pathways are incomplete.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hélène Barreteau, Andreja Kovac, Audrey Boniface, Matej Sova, Stanislav Gobec, Didier Blanot; ''Cytoplasmic steps of peptidoglycan biosynthesis ''; FEMS Microbiol Rev., 2008 PubMed Europe PMC Scholia
  2. Christoph Mayer, Robert Maria Kluj, Maraike Mühleck, Axel Walter, Sandra Unsleber, Isabel Hottmann, Marina Borisova; ''Bacteria's different ways to recycle their own cell wall''; Int J Med Microbiol., 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123880view10:45, 23 August 2022EgonwMissed one
123879view10:44, 23 August 2022EgonwReplaced a PubChem identifier with that of the neutral compound, with Wikidata mapping
116278view04:49, 26 April 2021KhanspersOntology Term : 'peptidoglycan biosynthetic pathway' added !
116273view15:09, 25 April 2021EgonwUpdated Uniprot-SwissProt to Uniprot-TrEMBL
115641view13:02, 3 March 2021EgonwCorrected the type of two metabolites (with ChEBI id)
115640view12:57, 3 March 2021EgonwModified title
115496view12:47, 24 February 2021Jpg64New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,6-anhMurNAcMetaboliteCHEBI:40666 (ChEBI)
1,6-anhydro-N-acetylmuramyl-L-alanine amidase (AmpD)ProteinP13016 (Uniprot-TrEMBL)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
D-Ala-D-AlaMetaboliteCHEBI:16576 (ChEBI)
D-AlaMetabolite71080 (PubChem-compound)
D-alanineMetaboliteCHEBI:15570 (ChEBI)
D-glucosamine-6-phosphateMetaboliteCHEBI:20995 (ChEBI)
D-glutamateMetaboliteCHEBI:29986 (ChEBI)
Diaminopimelic acidMetaboliteHMDB01370 (HMDB)
Fructose-6-phosphateMetaboliteCHEBI:15946 (ChEBI)
GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-AlaMetabolite163626 (PubChem-compound)
GlcNAc-6-PMetabolite150941 (PubChem-compound)
GlcNAcMetaboliteCHEBI:506227 (ChEBI)
Glucosamine-1PMetaboliteHMDB01109 (HMDB)
L-Ala-gamma-D-Glu-meso-DAP-D-AlaMetabolite51351779 (PubChem-compound)
L-Ala-gamma-D-Glu-meso-DAPMetabolite51351754 (PubChem-compound)
L-alanineMetaboliteCHEBI:16977 (ChEBI)
L-glutamateMetaboliteCHEBI:29985 (ChEBI)
MurNAc 6-phosphateMetaboliteCHEBI:47968 (ChEBI)
MurNAcMetabolite5462244 (PubChem-compound)
Murein tetrapeptide carboxypeptidase (LdcA)ProteinP76008 (Uniprot-TrEMBL)
N-acetylglucosamine-1-phosphateMetaboliteCHEBI:16446 (ChEBI)
NADPHMetaboliteHMDB00221 (HMDB)
Penicillin-binding protein 1AProteinP02918 (Uniprot-TrEMBL)
Penicillin-binding protein 1BProteinP02919 (Uniprot-TrEMBL)
Penicillin-binding protein 1CProteinP76577 (Uniprot-TrEMBL)
Penicillin-binding protein 2 (Peptidoglycan D,D-transpeptidase MrdA}ProteinQ2TL65 (Uniprot-TrEMBL)
Penicillin-binding protein 3 (Peptidoglycan D,D-transpeptidase FtsI)ProteinP0AD68 (Uniprot-TrEMBL)
Peptidoglycan LayerMetaboliteCHEBI:8005 (ChEBI)
TonB-dependent uptake?Protein
UDP-GlcNAc-enolpyruvateMetaboliteCHEBI:68483 (ChEBI)
UDP-GlcNAcMetaboliteCHEBI:16264 (ChEBI)
UDP-MurNAc-L-Ala-D-GluMetaboliteCHEBI:16970 (ChEBI)
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-AlaMetaboliteCHEBI:18199 (ChEBI)
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAPMetaboliteCHEBI:28639 (ChEBI)
UDP-MurNAc-L-AlaMetabolite5490066 (PubChem-compound)
UDP-MurNAcMetaboliteCHEBI:70765 (ChEBI)
UND-PP-MurNAc-L-Ala-D-Glu-meso-DAP-D-Ala-D-AlaMetabolite46173752 (PubChem-compound)
UTPMetaboliteCHEBI:46398 (ChEBI)
Undecaprenyl phosphateMetaboliteCHEBI:16141 (ChEBI)
Undecaprenyl pyrophosphateMetaboliteCHEBI:17047 (ChEBI)
Undecaprenyl-diphosphataseProteinP60932 (Uniprot-TrEMBL)
Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineMetaboliteCHEBI:28138 (ChEBI)
alrGeneProductP0A6B4 (Uniprot-TrEMBL)
ampGGeneProductP0AE16 (Uniprot-TrEMBL)
anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-AlaMetabolite
anmKGeneProductP77570 (Uniprot-TrEMBL)
dadXGeneProductP29012 (Uniprot-TrEMBL)
ddlBGeneProductP07862 (Uniprot-TrEMBL)
ftsWGeneProductP0ABG4 (Uniprot-TrEMBL)
glmMGeneProductP31120 (Uniprot-TrEMBL)
glmSGeneProductP17169 (Uniprot-TrEMBL)
glmUGeneProductP0ACC7 (Uniprot-TrEMBL)
glutamineMetaboliteCHEBI:28300 (ChEBI)
mplGeneProductP37773 (Uniprot-TrEMBL)
mraYGeneProductP0A6W3 (Uniprot-TrEMBL)
mtgAGeneProductP46022 (Uniprot-TrEMBL)
murAGeneProductP0A749 (Uniprot-TrEMBL)
murBGeneProductP08373 (Uniprot-TrEMBL)
murCGeneProductP17952 (Uniprot-TrEMBL)
murDGeneProductP14900 (Uniprot-TrEMBL)
murEGeneProductP22188 (Uniprot-TrEMBL)
murFGeneProductP11880 (Uniprot-TrEMBL)
murGGeneProductP17443 (Uniprot-TrEMBL)
murIGeneProductP22634 (Uniprot-TrEMBL)
murJGeneProductP0AF16 (Uniprot-TrEMBL)
murPGeneProductP77272 (Uniprot-TrEMBL)
murQGeneProductP76535 (Uniprot-TrEMBL)
nagAGeneProductP0AF18 (Uniprot-TrEMBL)
nagBGeneProductP0A759 (Uniprot-TrEMBL)
nagKGeneProductP75959 (Uniprot-TrEMBL)
nagZGeneProductP75949 (Uniprot-TrEMBL)
phosphoenolpyruvateMetaboliteCHEBI:58702 (ChEBI)

Annotated Interactions

No annotated interactions
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