Growth factors and hormones in beta cell proliferation (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Beta cellPDX1PI3KPDGFRATGFB1T3TGFB1RPref-1RTRsKRASP16ink4aInsulinPDGFAProliferationEZH2BRAFIGF-1RCa2+SMAD7PLGFRab43FLT1FOXO1IRIGF-1DLK1RASSF1T4T3Cyclin DCyclin AcMycCDK2CDK4FOXM1NFATCRTC2AKT1AKT2AKT3ERK 1ERK 2CaMName: Growth factors and hormones in beta cell proliferationOrganism: Homo sapiens


Description

Several growth factors and hormones interact with particular beta-cell receptors to start intracellular signaling pathways that encourage cell division and growth. Hormones including prolactin (PRL), thyroid hormone (TH), growth hormone (GH), glucagon-like peptide-1 (GLP-1), insulin-like growth factor-1 (IGF-1), and others have been closely linked. The modulation of B-cell proliferation has been linked to growth factors such as IGF-1, members of the epidermal growth factor (EGF) family, nerve growth factor (NGF), members of the transforming growth factor (TGF)-superfamily, placental growth factor (PLGF), and their corresponding receptors. This pathway provides information on how these various factors are realized. The figure is based on Jiang et al. (2018, doi: 10.3892/etm.2018.6603).

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

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  1. Chen H, Gu X., Liu Y., Wang J., Wirt SE, Bottino R., Schorle H., Sage J., Kim SK.; ''PDGF signalling controls age-dependent proliferation in pancreatic β-cells''; nature10502, 2011 PubMed Europe PMC Scholia
  2. Goodyer WR, Gu X, Liu Y, Bottino R, Crabtree GR, Kim SK; ''Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT.''; Dev Cell, 2012 PubMed Europe PMC Scholia
  3. Li J, Ying H, Cai G, Guo Q, Chen L; ''Pre-Eclampsia-Associated Reduction in Placental Growth Factor Impaired Beta Cell Proliferation Through PI3k Signalling.''; Cell Physiol Biochem, 2015 PubMed Europe PMC Scholia
  4. Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA; ''Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway.''; Elife, 2014 PubMed Europe PMC Scholia
  5. Kim TK, Lee JS, Jung HS, Ha TK, Kim SM, Han N, Lee EJ, Kim TN, Kwon MJ, Lee SH, Kim MK, Rhee BD, Park JH; ''Triiodothyronine induces proliferation of pancreatic β-cells through the MAPK/ERK pathway.''; Exp Clin Endocrinol Diabetes, 2014 PubMed Europe PMC Scholia
  6. Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS; ''Menin determines K-RAS proliferative outputs in endocrine cells.''; J Clin Invest, 2014 PubMed Europe PMC Scholia
  7. Wang C, Chen X, Ding X, He Y, Gu C, Zhou L; ''Exendin-4 Promotes Beta Cell Proliferation via PI3k/Akt Signalling Pathway.''; Cell Physiol Biochem, 2015 PubMed Europe PMC Scholia
  8. Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T; ''Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.''; Cell Metab, 2010 PubMed Europe PMC Scholia
  9. Park YJ, Yoo SA, Kim M, Kim WU; ''The Role of Calcium-Calcineurin-NFAT Signaling Pathway in Health and Autoimmune Diseases.''; Front Immunol, 2020 PubMed Europe PMC Scholia
  10. Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, Song Z, El-Gohary Y, Prasadan K, Shiota C, Gittes GK; ''M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7.''; Proc Natl Acad Sci U S A, 2014 PubMed Europe PMC Scholia
  11. Rhee M, Lee SH, Kim JW, Ham DS, Park HS, Yang HK, Shin JY, Cho JH, Kim YB, Youn BS, Sul HS, Yoon KH; ''Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells.''; Sci Rep, 2016 PubMed Europe PMC Scholia
  12. Demozay D, Tsunekawa S, Briaud I, Shah R, Rhodes CJ; ''Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells.''; Diabetes, 2011 PubMed Europe PMC Scholia
  13. Cerf ME, Williams K, Chapman CS, Louw J; ''Compromised beta-cell development and beta-cell dysfunction in weanling offspring from dams maintained on a high-fat diet during gestation.''; Pancreas, 2007 PubMed Europe PMC Scholia
  14. Jiang WJ, Peng YC, Yang KM; ''Cellular signaling pathways regulating β-cell proliferation as a promising therapeutic target in the treatment of diabetes.''; Exp Ther Med, 2018 PubMed Europe PMC Scholia
  15. Wang H, Gambosova K, Cooper ZA, Holloway MP, Kassai A, Izquierdo D, Cleveland K, Boney CM, Altura RA; ''EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-cells.''; BMC Mol Biol, 2010 PubMed Europe PMC Scholia
  16. Gao Y, Liao G, Xiang C, Yang X, Cheng X, Ou Y; ''Effects of phycocyanin on INS-1 pancreatic β-cell mediated by PI3K/Akt/FoxO1 signaling pathway.''; Int J Biol Macromol, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137364
Approved
view22:23, 1 March 2025EweitzFix membrane position
137363view22:22, 1 March 2025EweitzUse gene symbols
137362view22:14, 1 March 2025EweitzColor process node teal
137361view22:12, 1 March 2025EweitzUse standard metabolite color
137360view22:07, 1 March 2025EweitzRefine cell layering, align nodes
137359view22:06, 1 March 2025EweitzEconomize layout
137358view22:03, 1 March 2025EweitzStack nodes
137357view22:02, 1 March 2025EweitzAlign nodes
137356view22:01, 1 March 2025EweitzTailor node height
128454view18:44, 4 February 2024EweitzModified title
128453view18:43, 4 February 2024EweitzRefine node alignment
128452view18:41, 4 February 2024EweitzEconomize layout
128451view18:23, 4 February 2024EweitzEconomize node dimensions
127774view20:16, 4 December 2023Khanspersminor layout change
126898view12:01, 30 June 2023Cereno98Missing Reference update
126897view11:53, 30 June 2023Tesic petraAlignment of the data nodes
126896view11:15, 30 June 2023Leyla ÖnderPoliferation - data node
126895view11:09, 30 June 2023Tesic petraAdding the reference to the title section
126894view11:05, 30 June 2023Tesic petraRemovement of the squares on the lines
126893view11:01, 30 June 2023Cereno98Fixing not connected arrows.
126892view10:57, 30 June 2023Cereno98connection error removal
126827view07:49, 26 June 2023Tesic petraModified description
126820view09:53, 25 June 2023EgonwRemoved whitespace from a few datanode labels
126746view17:04, 16 June 2023Cereno98References updated
126745view16:57, 16 June 2023Cereno98reference update
126729view23:09, 15 June 2023Cereno98Modified description
126728view20:58, 15 June 2023Tesic petraModified title
126727view20:18, 15 June 2023Leyla ÖnderReferences
126726view19:02, 15 June 2023Cereno98Reference addition
126712view13:14, 14 June 2023Leyla ÖnderComments on the DataNodes
126711view11:36, 14 June 2023Cereno98gene
126710view11:35, 14 June 2023Cereno98complex
126709view11:34, 14 June 2023Cereno98id
126708view11:34, 14 June 2023Cereno98protein
126707view11:29, 14 June 2023Cereno98Metabolite ID update
126706view11:28, 14 June 2023Cereno98Correction of metabolites
126705view10:44, 14 June 2023Cereno98Modified description
126704view10:43, 14 June 2023Cereno98Modified description
126703view08:37, 14 June 2023Leyla ÖnderOntology Term : 'transforming growth factor-beta superfamily mediated signaling pathway' added !
126702view08:36, 14 June 2023Leyla ÖnderOntology Term : 'Ras family mediated signaling pathway' added !
126701view08:33, 14 June 2023Leyla ÖnderOntology Term : 'calcium/calcium-mediated signaling pathway' added !
126700view08:32, 14 June 2023Leyla ÖnderOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
126699view08:32, 14 June 2023Leyla ÖnderOntology Term : 'insulin signaling pathway' added !
126698view08:28, 14 June 2023Leyla ÖnderOntology Term : 'type B pancreatic cell' added !
126697view07:30, 14 June 2023Leyla ÖnderNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProductP31749 (Uniprot-TrEMBL)
AKT2GeneProductP31751 (Uniprot-TrEMBL)
AKT3GeneProductQ9Y243 (Uniprot-TrEMBL)
BRAFGeneProductP15056 (Uniprot-TrEMBL) "B-Raf" originally
CDK2GeneProductP24941 (Uniprot-TrEMBL)
CDK4GeneProductP11802 (Uniprot-TrEMBL)
CRTC2GeneProductQ53ET0 (Uniprot-TrEMBL)
Ca2+Metabolite29108 (ChEBI)
CaMGeneProductUniProt provides different types of Calmodulin proteins. The publication does not state which CaM is involved in the ß-proliferation. While searching for a family identifier with InterPro, no results were retrieved.
Cyclin AGeneProductThere are two types of Cyclin A: A1 and A2. There is no specifcation about which type is important and no InterPro identifiers is found.
Cyclin DGeneProductThere are two types of Cyclin D: D1,D2 and D3. There is no specifcation about which type is important and no InterPro identifiers is found.
DLK1GeneProductP80370 (Uniprot-TrEMBL) "Pref-1" originally. Synonyms: Dlk-1
ERK 1GeneProductP27361 (Uniprot-TrEMBL)
ERK 2GeneProductP28482 (Uniprot-TrEMBL)
EZH2GeneProductQ75MQ0 (Uniprot-TrEMBL)
FLT1GeneProductP17948 (Uniprot-TrEMBL) The pathway figure names the receptor for PLGF as PLGF. The UniProt websites states that the receptor for PLGF is VEGFR-1. But the original publication (PMID: 25924650) states VEGFR-1 as receptor. "VEGFR-1" originally.
FOXM1GeneProductQ08050 (Uniprot-TrEMBL)
FOXO1GeneProductQ12778 (Uniprot-TrEMBL)
IGF-1GeneProductP05019 (Uniprot-TrEMBL)
IGF-1RGeneProductP08069 (Uniprot-TrEMBL) In contrast to the pathway figure, the specific receptor was included as DataNode.
IRGeneProductP06213 (Uniprot-TrEMBL) In contrast to the pathway figure, the specific receptor was included as DataNode.
InsulinGeneProductP01308 (Uniprot-TrEMBL)
KRASGeneProductP01116 (Uniprot-TrEMBL) "K-Ras" originally
NFATGeneProductIPR008366 (InterPro) The InterPro indentifier for the family was selected, as no specifc protein of the family was stated in the publication.
P16ink4aGeneProductR9S252 (Uniprot-TrEMBL)
PDGFAGeneProductP04085 (Uniprot-TrEMBL) "PDGFa" originally
PDGFRAGeneProductA0A387LBM6 (Uniprot-TrEMBL) In contrast to the pathway figure, the specific receptor was included as DataNode. "PDGFR-a" originally.
PDX1GeneProductP52945 (Uniprot-TrEMBL) "Pdx1" originally
PI3KGeneProductIPR000403 (InterPro) The InterPro indentifier for the family was selected, as no specifc protein of the family was stated in the publication.
PLGFGeneProductP49763 (Uniprot-TrEMBL)
Pref-1RGeneProductNo identifier was found.
ProliferationQ189101 (Wikidata)
RASSF1GeneProductQ9NS23 (Uniprot-TrEMBL) "Rasf1a" originally
Rab43GeneProductQ86YS6 (Uniprot-TrEMBL)
SMAD7GeneProductO15105 (Uniprot-TrEMBL) "Smad7" originally
T3Metabolite18258 (ChEBI)
T4Metabolite18332 (ChEBI)
TGFB1GeneProductP01137 (Uniprot-TrEMBL)
TGFB1RGeneProductP36897 (Uniprot-TrEMBL)
TRsGeneProductIPR001728 (InterPro)
cMycGeneProductP01106 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5385"
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