IDO metabolic pathway (Homo sapiens)

From WikiPathways

Revision as of 15:20, 20 January 2024 by Eweitz (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Glucocorticoid stimuliPro-inflammatorycytokinesIFNGINFATNFAActivation of inflammationand generation of ROS3-HydroxykynurenineKynurenic acidPicolinic acidL-TryptophanKYNU3-Hydroxyanthranilic acidKAT1KAT3AADATAATMQuinolinic acidNeopterinAnthranilic acidKynurenineNAD+KMOIDO1IDO2T23OKYNUName: IDO metabolic pathwayOrganism: Homo sapiens


Description

Overview of the IDO metabolic pathway. Approximately 95% of L-tryptophan (Trp) is catabolized into kynurenine (Kyn) through three rate-limiting enzymes: tryptophan 2,3-dioxygenase (TDO) in the liver and indoleamine 2, 3-dioxygenase 1/2 (IDO1/2) in peripheral tissues. Kyn is converted to 3-hydroxykynurenine (3-HK) by kynurenine 3-monooxygenase (KMO), to anthranilic acid (AA) by kynureninase (KYNase), or to kynurenic acid (KYNA) by kynurenine aminotransferase (KAT). Next, catalyzed by KYNase, 3-HK is converted to 3-hydroxyanthranilic acid (3-HAA), which is further converted to quinolinic acid (QA), picolinic acid, nicotinamide adenine dinucleotide (NAD+), and other molecules. Starting point: https://pfocr.wikipathways.org/figures/PMC6090955__13045_2018_644_Fig1_HTML.html

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:Wplogo_31.pngCommunity: COVID-19
Image:Curated.pngApproved version

Ontology Terms

Disease : heart disease
 

Bibliography

  1. Liu M, Wang X, Wang L, Ma X, Gong Z, Zhang S, Li Y; ''Targeting the IDO1 pathway in cancer: from bench to bedside.''; J Hematol Oncol, 2018 PubMed Europe PMC Scholia
  2. Lawler NG, Gray N, Kimhofer T, Boughton B, Gay M, Yang R, Morillon AC, Chin ST, Ryan M, Begum S, Bong SH, Coudert JD, Edgar D, Raby E, Pettersson S, Richards T, Holmes E, Whiley L, Nicholson JK; ''Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses.''; J Proteome Res, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127968
COVID
Approved
view15:20, 20 January 2024EweitzStandardize case
127286view21:06, 1 September 2023Mkutmonadded missing identifier
127285view21:03, 1 September 2023Mkutmonremove unused ref
127284view21:01, 1 September 2023MkutmonModified description
127283view21:00, 1 September 2023Mkutmonadded some additional info from second paper
127282view20:35, 1 September 2023MkutmonModified description
127281view20:34, 1 September 2023MkutmonModified description
127280view20:22, 1 September 2023MkutmonOntology Term : 'tryptophan metabolic pathway' added !
127279view20:20, 1 September 2023MkutmonOntology Term : 'classic metabolic pathway' added !
127278view20:20, 1 September 2023MkutmonNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
3-Hydroxyanthranilic acidMetaboliteCHEBI:15793 (ChEBI)
3-HydroxykynurenineMetaboliteCHEBI:1547 (ChEBI)
AADATProteinQ8N5Z0 (Uniprot-TrEMBL)
AATMProteinP00505 (Uniprot-TrEMBL)
Anthranilic acidMetaboliteCHEBI:30754 (ChEBI)
IDO1ProteinP14902 (Uniprot-TrEMBL)
IDO2ProteinQ6ZQW0 (Uniprot-TrEMBL)
IFNGProteinP01579 (Uniprot-TrEMBL)
INFAProtein
KAT1ProteinQ16773 (Uniprot-TrEMBL)
KAT3ProteinQ6YP21 (Uniprot-TrEMBL)
KMOProteinO15229 (Uniprot-TrEMBL)
KYNUProteinQ16719 (Uniprot-TrEMBL)
Kynurenic acidMetaboliteCHEBI:18344 (ChEBI)
KynurenineMetaboliteCHEBI:57959 (ChEBI)
L-TryptophanMetaboliteCHEBI:16828 (ChEBI)
NAD+MetaboliteCHEBI:13389 (ChEBI)
NeopterinMetabolite2009-64-5 (CAS)
Picolinic acidMetaboliteCHEBI:28747 (ChEBI)
Quinolinic acidMetaboliteCHEBI:16675 (ChEBI)
T23OProteinP48775 (Uniprot-TrEMBL)
TNFAProteinP01375 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Personal tools