GIP and GLP-1 function by tissue (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Beta cellGIPApoptosisBone formationInsulinGLP-1FataccumulationMemoryGastricemptyingCardioprotectionGlucagonProliferationCardiac outputPancreasBrainGI tractAdipose tissueBoneHeartHungerGastric acidsecretionGCGName: GIP and GLP-1 function by tissueOrganism: Homo sapiens


Description

Functions of GIP and GLP-1, two agonists of which are found in the weight-loss drug tirzepatide (a.k.a. Mounjaro). "Pancreatic and exopancreatic function of glucose‐dependent insulinotropic polypepide (GIP) and glucagon‐like peptide (GLP)‐1. GIP acts directly on the endocrine pancreas, bone, fat, gastrointestinal (GI) tract and brain. GLP‐1 acts directly on the endocrine pancreas, gastrointestinal tract, heart and brain." From Figure 2 in https://pmc.ncbi.nlm.nih.gov/articles/PMC4020673/.

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Bibliography

  1. Seino Y, Fukushima M, Yabe D; ''GIP and GLP-1, the two incretin hormones: Similarities and differences.''; J Diabetes Investig, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
136293
Approved
view14:40, 22 January 2025EgonwTypo in identifier
136282view01:24, 17 January 2025EweitzModified description
136281view01:23, 17 January 2025EweitzOntology Term : 'type B pancreatic cell' added !
136280view01:22, 17 January 2025EweitzOntology Term : 'intestinal epithelial cell' added !
136279view01:21, 17 January 2025EweitzOntology Term : 'neuron' added !
136278view01:14, 17 January 2025EweitzRefine alignment
136277view01:13, 17 January 2025EweitzAdjust layering
136276view01:12, 17 January 2025EweitzRefine interaction types
136275view00:56, 17 January 2025EweitzAdd literature reference
136274view00:55, 17 January 2025EweitzAdd identifiers
136273view23:57, 16 January 2025EweitzAlign interactions
136272view23:47, 16 January 2025EweitzMute colors; was too noisy
136271view23:10, 16 January 2025EweitzColor tissue boundaries
136270view22:52, 16 January 2025EweitzDeduplicate column to simplify diagram
136269view22:32, 16 January 2025EweitzConvert straight lines to elbow, to make inhibition glanceable
136268view22:28, 16 January 2025EweitzConvert concept to pathway
136267view13:17, 16 January 2025EweitzReplace some concepts with pathways
136266view13:06, 16 January 2025EweitzAdd interactions
136264view02:16, 16 January 2025EweitzAdd tissue, cell type containers
136263view02:00, 16 January 2025EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ApoptosisPathwayWP254 (WikiPathways)
Bone formationQ1121544 (Wikidata)
Cardiac outputQ596579 (Wikidata)
CardioprotectionQ25325349 (Wikidata)
Fat accumulation
GCGGeneProductENSG00000115263 (Ensembl)
GIPGeneProductENSG00000159224 (Ensembl)
GLP-1GeneProductENSG00000115263 (Ensembl)
Gastric emptyingQ14916441 (Wikidata)
Gastric acid secretionPathwayWP2596 (WikiPathways)
GlucagonMetaboliteCHEBI:5391 (ChEBI)
HungerPathwayWP5445 (WikiPathways)
InsulinMetaboliteCHEBI:5931 (ChEBI)
MemoryQ492 (Wikidata)
ProliferationQ189101 (Wikidata)

Annotated Interactions

No annotated interactions

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