NSAIDs mechanism of action (Homo sapiens)
From WikiPathways
Description
"Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the cyclooxygenase isoenzymes COX1 and COX2 with varying degrees of specificity for the COX2 isoform. As a result, the conversion of arachidonic acid to prostaglandins (PGs) is inhibited. The main effects of PGs throughout the body are listed." Inspired by Figure 1 in PMID:32322101.
Quality Tags
Ontology Terms
Pathway Ontology : calcium/calmodulin dependent signaling pathway G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphas family Ras superfamily mediated signaling pathway G protein mediated signaling pathway via Galphaq family endothelin signaling pathway
Disease : hypertension benign essential hypertension
Cell Type : smooth muscle cell blood vessel endothelial cell
Bibliography
- Schjerning AM, McGettigan P, Gislason G; ''Cardiovascular effects and safety of (non-aspirin) NSAIDs.''; Nat Rev Cardiol, 2020 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
Angiogenesis | Pathway | WP1539 (WikiPathways) ![]() | |
Arachidonic acid | Metabolite | ||
COX1 | GeneProduct | ||
COX2 | GeneProduct | ||
Celecoxib | Metabolite | DB00482 (DrugBank) ![]() | |
Cell proliferation | Q189101 (Wikidata) ![]() | ||
Diclofenac | Metabolite | DB00586 (DrugBank) ![]() | |
Hemostasis | Q487937 (Wikidata) ![]() | ||
Ibuprofen | Metabolite | DB01050 (DrugBank) ![]() | |
Inflammation | Q101991 (Wikidata) ![]() | ||
Metastasis | Q181876 (Wikidata) ![]() | ||
Naproxen | Metabolite | DB00788 (DrugBank) ![]() | |
PGA1 | Metabolite | CHEBI:15545 (ChEBI) ![]() | |
PGD2 | Metabolite | CHEBI:15555 (ChEBI) ![]() | |
PGE1 | Metabolite | CHEBI:15544 (ChEBI) ![]() | |
PGE2 | Metabolite | CHEBI:15551 (ChEBI) ![]() | |
PGF2a | Metabolite | CHEBI:15553 (ChEBI) ![]() | |
PGG2 | Metabolite | CHEBI:27647 (ChEBI) ![]() | |
PGH2 | Metabolite | CHEBI:15554 (ChEBI) ![]() | |
PGI2 | Metabolite | CHEBI:15552 (ChEBI) ![]() | |
Pain | Q81938 (Wikidata) ![]() | ||
Protection of gastric mucosa | Q383249 (Wikidata) ![]() | ||
Rofecoxib | Metabolite | DB00533 (DrugBank) ![]() | |
Tissue injury | Q21119857 (Wikidata) ![]() |
Annotated Interactions
No annotated interactions