Asparagine biosynthesis (Saccharomyces cerevisiae)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none L-asparagineL-aspartateOxaloacetic acid2-oxoglutarateL-glutamatepyrophosphateL-glutamateAMPAAT1AAT2ASN2ASN1ATPH2OL-glutamineName: Asparagine biosynthesisOrganism: Saccharomyces cerevisiae


Description

The precursor to asparagine is oxaloacetate, which the AAT enzyme converts to aspartate by transferring the amino group from glutamate to oxaloacetate, producing α-ketoglutarate and aspartate. The enzyme ASN produces asparagine, AMP, glutamate, and pyrophosphate from aspartate, glutamine, and ATP. Description adapted from [Wikipedia](https://en.wikipedia.org/wiki/Asparagine).

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Quality Tags

Ontology Terms

 

Bibliography

  1. ''L-asparagine biosynthesis I''; YeastPathways,
  2. Noree C, Sirinonthanawech N, Wilhelm JE; ''Saccharomyces cerevisiae ASN1 and ASN2 are asparagine synthetase paralogs that have diverged in their ability to polymerize in response to nutrient stress.''; Sci Rep, 2019 PubMed Europe PMC Scholia
  3. Lam HM, Hsieh MH, Coruzzi G; ''Reciprocal regulation of distinct asparagine synthetase genes by light and metabolites in Arabidopsis thaliana.''; Plant J, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139490view05:59, 20 June 2025EgonwAdded two references (which seem relevant)
139424view03:39, 17 June 2025EgonwWater with unicode
137467view14:54, 2 March 2025EgonwModified description
135937view02:11, 3 December 2024Khanspersupdated to mim-conversion
135440view21:38, 5 September 2024Khanspers
135439view21:37, 5 September 2024Khanspersupdated lit ref
135438view21:36, 5 September 2024Khanspersremoved lit ref
135437view21:34, 5 September 2024KhanspersOntology Term : 'classic metabolic pathway' added !
135436view21:33, 5 September 2024Khanspersremoved GenMAPP comments
135435view21:33, 5 September 2024KhanspersModified description
135413view19:12, 4 September 2024Khanspersoverhaul, reference
117278view10:45, 20 May 2021EweitzModified title
86833view13:40, 12 July 2016MkutmonOntology Term : 'asparagine metabolic pathway' added !
86832view13:40, 12 July 2016MkutmonOntology Term : 'PW:0019266' removed !
71349view18:02, 17 October 2013MaintBotAutomated update of data sources
70047view05:56, 12 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69635view20:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
67065view10:01, 26 June 2013Christine ChichesterOntology Term : 'asparagine biosynthetic process from oxaloacetate' added !
53718view20:05, 12 November 2012EgonwReplaced multiple general nodes by Metabolite DataNode's.
45181view09:14, 7 October 2011Mkutmonconnected lines
41871view04:52, 2 March 2011MaintBotRemoved redundant pathway information and comments
36641view22:37, 9 April 2010MaintBotDescription and bibliography added from SGD
20819view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Asparagine Biosynthesis]] moved to [[Pathway:WP67]]: Moved to stable identifier
12660view07:56, 17 May 2008MaintBotautomated metabolite conversion
8651view14:05, 7 January 2008MaintBotAdded to category $category
8649view14:05, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
AAT1GeneProductS000001589 (SGD)
AAT2GeneProductS000004017 (SGD)
AMPMetaboliteCHEBI:16027 (ChEBI)
ASN1GeneProductS000006349 (SGD)
ASN2GeneProductS000003356 (SGD)
ATPMetabolite1927-31-7 (CAS)
H2OMetaboliteHMDB02111 (HMDB)
L-asparagineMetabolite70-47-3 (CAS)
L-aspartateMetaboliteCHEBI:29991 (ChEBI)
L-glutamateMetabolite56-86-0 (CAS)
L-glutamineMetabolite56-85-9 (CAS)
Oxaloacetic acidMetaboliteCHEBI:30744 (ChEBI)
pyrophosphateMetabolite2466-09-3 (CAS)

Annotated Interactions

No annotated interactions

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