Fatty acid oxidation (Saccharomyces cerevisiae)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none fatty acida 3-oxoacyl-CoA(3S)-3-hydroxyacyl-CoAH2ONADcis-delta-2-enoyl-CoAH+O2trans-delta-2-enoyl-CoAAMPpyrophosphateNADHPOX1acetyl-CoAacyl(n-2)-CoAPOT1acyl-CoACoenzyme ACoenzyme AH2O2FOX2ATPFAA1FAA3FAA4FAT1FAA2ECI1DCI1FOX2Name: Fatty acid oxidationOrganism: Saccharomyces cerevisiae


Description

In most organisms, the primary mode of fatty acid catabolism is oxidation. The oxidation cycle catalyzes the complete oxidation of a fatty acid molecule, removing two carbon atoms (in the form of acetyl-CoA) with each turn of the cycle. The subcellular location in which oxidation occurs varies by organism; in bacteria, oxidation occurs in the cytoplasm, whereas in mammalian cells it occurs in both the mitochondria and the peroxisome. In contrast, oxidation in S. cerevisiae, plants, and most other fungi occurs exclusively in the peroxisome. Description from [YeastPathways](https://pathway.yeastgenome.org/)

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

  1. ''Fatty acid oxidation pathway''; YeastPathways,
  2. van Roermund CW, Waterham HR, Ijlst L, Wanders RJ; ''Fatty acid metabolism in Saccharomyces cerevisiae.''; Cell Mol Life Sci, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138120
Approved
view15:39, 15 March 2025EgonwAdded a PubMed reference
136879view10:33, 26 February 2025EgonwModified description
135434view21:26, 5 September 2024KhanspersOntology Term : 'classic metabolic pathway' added !
135433view21:25, 5 September 2024KhanspersModified description
135432view21:24, 5 September 2024KhanspersModified description
135431view21:23, 5 September 2024KhanspersModified description
135430view21:22, 5 September 2024KhanspersModified description
135429view21:22, 5 September 2024KhanspersModified description
135428view21:21, 5 September 2024Khanspersremoved GenMAPP comments
135427view21:19, 5 September 2024KhanspersModified description
135421view17:50, 5 September 2024Khanspersupdated lit ref
135420view17:48, 5 September 2024Khanspersadded lit ref
135418view17:34, 5 September 2024Khanspersoverhaul
124911view10:54, 31 December 2022EgonwA bit more FAIR
124906view08:37, 31 December 2022EgonwFixed the AcylCoA identifier
124905view08:35, 31 December 2022EgonwRemoved an outdated "last modified"
107031view13:48, 17 September 2019MaintBotHMDB identifier normalization
71343view18:01, 17 October 2013MaintBotAutomated update of data sources
70052view05:59, 12 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69604view20:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
67249view10:26, 26 June 2013Christine ChichesterOntology Term : 'fatty acid degradation pathway' added !
54771view07:09, 9 December 2012EgonwReplaced multiple general nodes by Metabolite DataNode's.
48034view14:08, 27 April 2012MartijnVanIersellinked reactions
48033view13:57, 27 April 2012MartijnVanIersellinked reactions, added peroxide
41836view04:50, 2 March 2011MaintBotRemoved redundant pathway information and comments
20873view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Fatty Acid Oxidation Pathway]] moved to [[Pathway:WP91]]: Moved to stable identifier
12704view07:59, 17 May 2008MaintBotautomated metabolite conversion
8714view14:07, 7 January 2008MaintBotAdded to category $category
8712view14:07, 7 January 2008J.HeckmanUploaded new pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
(3S)-3-hydroxyacyl-CoAMetabolite15455 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
ATPMetabolite1927-31-7 (CAS)
Coenzyme AMetabolite64885-97-8 (CAS)
DCI1GeneProductS000005706 (SGD)
ECI1GeneProductS000004274 (SGD)
FAA1GeneProductS000005844 (SGD)
FAA2GeneProductS000000817 (SGD)
FAA3GeneProductS000001271 (SGD)
FAA4GeneProductS000004860 (SGD)
FAT1GeneProductS000000245 (SGD)
FOX2GeneProductS000001717 (SGD)
H+MetaboliteHMDB59597 (HMDB)
H2O2MetaboliteHMDB0003125 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
NADHMetabolite53-84-9 (CAS)
NADMetaboliteHMDB00902 (HMDB)
O2Metabolite15379 (ChEBI)
POT1GeneProductS000001422 (SGD)
POX1GeneProductS000003173 (SGD)
a 3-oxoacyl-CoAMetaboliteCHEBI:57347 (ChEBI)
acetyl-CoAMetabolite72-89-9 (CAS)
acyl(n-2)-CoAMetaboliteCHEBI:17984 (ChEBI)
acyl-CoAMetaboliteCHEBI:17984 (ChEBI)
cis-delta-2-enoyl-CoAMetaboliteC05057 (KEGG Compound)
fatty acidMetaboliteCHEBI:35366 (ChEBI)
pyrophosphateMetabolite2466-09-3 (CAS)
trans-delta-2-enoyl-CoAMetaboliteC00658 (KEGG Compound)

Annotated Interactions

No annotated interactions

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