Farnesoid X receptor pathway (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Farnesoid X Receptor Pathway" Version="20120227" Organism="Bos taurus"> <Comment Source="WikiPathways-description">The farnesoid X receptor (FXR, a.k.a. NR1H4) is a nuclear receptor that responds to levels of bile acids present in the body and regulates many processes related to bile acids synthesis and transport. </Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP2879_r79602 WP2879(79602)] with a 100.0% conversion rate.</Comment> <BiopaxRef>cc1</BiopaxRef> <Graphics BoardWidth="895.1877133105809" BoardHeight="1149.4539249146756"/> <DataNode TextLabel="NR1H4" GraphId="f8ef6" Type="GeneProduct"> <Comment>nuclear receptor subfamily 1, group H, member 4 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9971</Comment> <BiopaxRef>fa4</BiopaxRef> <Graphics CenterX="348.84194590231226" CenterY="205.21881343386295" Width="80.0" Height="20.0" ZOrder="33645" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000013596"/> </DataNode> <DataNode TextLabel="FXR ligand" GraphId="e5711" Type="Metabolite"> <Comment>T3</Comment> <Graphics CenterX="348.8419459023123" CenterY="27.973218636719437" Width="79.99999999999999" Height="20.00000000000001" ZOrder="33648" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:48705"/> </DataNode> <DataNode TextLabel="NR1H4" GraphId="a6074" Type="GeneProduct" GroupRef="f095d"> <Comment>nuclear receptor subfamily 1, group H, member 4</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9971</Comment> <BiopaxRef>fa4</BiopaxRef> <Graphics CenterX="348.8419459023123" CenterY="556.3905771460977" Width="80.0" Height="20.0" ZOrder="33649" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000013596"/> </DataNode> <DataNode TextLabel="RXRA" GraphId="af061" Type="GeneProduct" GroupRef="f095d"> <Comment>retinoid X receptor, alpha </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6256</Comment> <Graphics CenterX="348.8419459023123" CenterY="536.3905771460977" Width="80.0" Height="20.0" ZOrder="33650" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000017851"/> </DataNode> <DataNode TextLabel="Ligand" GraphId="cb913" Type="Metabolite" GroupRef="f095d"> <Graphics CenterX="348.8419459023122" CenterY="516.3905771460975" Width="79.99999999999999" Height="20.00000000000001" ZOrder="33651" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:48705"/> </DataNode> <DataNode TextLabel="NR1H4" GraphId="e5b44" Type="GeneProduct" GroupRef="f1719"> <Comment>nuclear receptor subfamily 1, group H, member 4</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9971</Comment> <BiopaxRef>fa4</BiopaxRef> <Graphics CenterX="348.8419459023122" CenterY="736.8435291651325" Width="80.0" Height="20.0" ZOrder="33660" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000013596"/> </DataNode> <DataNode TextLabel="RXRA" GraphId="fe9c0" Type="GeneProduct" GroupRef="f1719"> <Comment>retinoid X receptor, alpha </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6256</Comment> <Graphics CenterX="348.8419459023122" CenterY="716.8435291651327" Width="80.0" Height="20.0" ZOrder="33661" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000017851"/> </DataNode> <DataNode TextLabel="Ligand" GraphId="d4189" Type="Metabolite" GroupRef="f1719"> <Graphics CenterX="348.84194590231226" CenterY="696.8435291651325" Width="79.99999999999999" Height="20.00000000000001" ZOrder="33662" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:48705"/> </DataNode> <DataNode TextLabel="NR1H4" GraphId="c282c" Type="GeneProduct" GroupRef="b11cd"> <Comment>nuclear receptor subfamily 1, group H, member 4 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9971</Comment> <BiopaxRef>fa4</BiopaxRef> <Graphics CenterX="348.8419459023122" CenterY="378.5581955883461" Width="80.0" Height="20.0" ZOrder="33665" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000013596"/> </DataNode> <DataNode TextLabel="Ligand" GraphId="bee75" Type="Metabolite" GroupRef="b11cd"> <Graphics CenterX="348.8419459023123" CenterY="358.55819558834725" Width="79.99999999999999" Height="20.00000000000001" ZOrder="33666" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:48705"/> </DataNode> <DataNode TextLabel="RXRA" GraphId="b32ae" Type="GeneProduct"> <Comment>retinoid X receptor, alpha </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6256</Comment> <Graphics CenterX="578.8100219406099" CenterY="385.20286532346125" Width="80.0" Height="20.0" ZOrder="33667" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000017851"/> </DataNode> <DataNode TextLabel="UGT2B4" GraphId="f08f4" Type="GeneProduct"> <Comment>UDP glucuronosyltransferase 2 family, polypeptide B4 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7363</Comment> <Graphics CenterX="391.5592206570953" CenterY="906.3137059203383" Width="80.0" Height="20.0" ZOrder="33671" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000040337"/> </DataNode> <DataNode TextLabel="SULT2A1" GraphId="d29ba" Type="GeneProduct"> <Comment>sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6822</Comment> <Graphics CenterX="391.5592206570953" CenterY="886.313705920339" Width="80.0" Height="20.0" ZOrder="33672" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000039971"/> </DataNode> <DataNode TextLabel="SLC27A5" GraphId="fa11e" Type="GeneProduct"> <Comment>solute carrier family 27 (fatty acid transporter), member 5 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10998</Comment> <Graphics CenterX="513.0300505667102" CenterY="1000.2496138907576" Width="80.0" Height="20.0" ZOrder="33673" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000015164"/> </DataNode> <DataNode TextLabel="SLC10A1" GraphId="e0930" Type="GeneProduct"> <Comment>solute carrier family 10 (sodium/bile acid cotransporter), member 1 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6554</Comment> <Graphics CenterX="393.19438910410264" CenterY="1019.7072967173805" Width="80.0" Height="20.0" ZOrder="33675" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000001881"/> </DataNode> <DataNode TextLabel="CYP7A1" GraphId="b1b19" Type="GeneProduct" GroupRef="be8fe"> <Comment>cytochrome P450, family 7, subfamily A, polypeptide 1 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581</Comment> <BiopaxRef>cd6</BiopaxRef> <Graphics CenterX="516.0374458009" CenterY="906.3137059203401" Width="80.0" Height="20.0" ZOrder="33676" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005287"/> </DataNode> <DataNode TextLabel="NR0B2" GraphId="d1437" Type="GeneProduct"> <Comment>nuclear receptor subfamily 0, group B, member 2 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8431</Comment> <BiopaxRef>b6a</BiopaxRef> <Graphics CenterX="612.8992457678407" CenterY="989.1005911662406" Width="80.0" Height="20.0" ZOrder="33677" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000014848"/> </DataNode> <DataNode TextLabel="FGF19" GraphId="f0121" Type="GeneProduct"> <Comment>fibroblast growth factor 19 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9965</Comment> <BiopaxRef>bed</BiopaxRef> <Graphics CenterX="516.9012833994309" CenterY="866.313705920341" Width="80.0" Height="20.0" ZOrder="33678" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000017285"/> </DataNode> <DataNode TextLabel="IRS2" GraphId="e3a72" Type="GeneProduct"> <Comment>insulin receptor substrate 2 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660</Comment> <Graphics CenterX="612.8992457678407" CenterY="909.1005911662425" Width="80.0" Height="20.0" ZOrder="33680" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012019"/> </DataNode> <DataNode TextLabel="ABCB11" GraphId="ba8ea" Type="GeneProduct"> <Comment>ATP-binding cassette, sub-family B (MDR/TAP), member 11</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8647</Comment> <Graphics CenterX="393.19438910410264" CenterY="998.8434591188492" Width="80.0" Height="20.0" ZOrder="33681" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000026885"/> </DataNode> <DataNode TextLabel="BAAT" GraphId="e8f80" Type="GeneProduct"> <Comment>bile acid CoA:amino acid N-acyltransferase</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:570</Comment> <Graphics CenterX="513.0300505667102" CenterY="1020.2496138907574" Width="80.0" Height="20.0" ZOrder="33682" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000025760"/> </DataNode> <DataNode TextLabel="CYP3A4" GraphId="f8caf" Type="GeneProduct"> <Comment>cytochrome P450, family 3, subfamily A, polypeptide 4 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1576</Comment> <BiopaxRef>cd6</BiopaxRef> <Graphics CenterX="391.5592206570953" CenterY="866.3137059203392" Width="80.0" Height="20.0" ZOrder="33683" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000047379"/> </DataNode> <DataNode TextLabel="FKBP5" GraphId="f4732" Type="GeneProduct"> <Comment>FK506 binding protein 5 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2289</Comment> <Graphics CenterX="612.8992457678407" CenterY="929.1005911662415" Width="80.0" Height="20.0" ZOrder="33684" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000047502"/> </DataNode> <DataNode TextLabel="UQCC2" GraphId="cf1e8" Type="GeneProduct"> <Comment>inositol hexakisphosphate kinase 3</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:117283</Comment> <Graphics CenterX="612.8992457678407" CenterY="949.1005911662411" Width="80.0" Height="20.0" ZOrder="33685" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000033603"/> </DataNode> <DataNode TextLabel="ABCB4" GraphId="b636d" Type="GeneProduct"> <Comment>ATP-binding cassette, sub-family B (MDR/TAP), member 4</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5244</Comment> <Graphics CenterX="393.19438910410264" CenterY="979.7072967173809" Width="80.0" Height="20.0" ZOrder="33686" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005653"/> </DataNode> <DataNode TextLabel="NR0B2" GraphId="dac23" Type="GeneProduct"> <Comment>nuclear receptor subfamily 0, group B, member 2</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8431</Comment> <Graphics CenterX="516.0374458008995" CenterY="886.3137059203412" Width="80.0" Height="20.0" ZOrder="33687" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000014848"/> </DataNode> <DataNode TextLabel="PPARGC1A" GraphId="caef5" Type="GeneProduct"> <Comment>peroxisome proliferator-activated receptor gamma, coactivator 1 alpha</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10891</Comment> <BiopaxRef>b6a</BiopaxRef> <Graphics CenterX="612.8992457678407" CenterY="969.1005911662406" Width="80.0" Height="20.0" ZOrder="33688" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000017024"/> </DataNode> <DataNode TextLabel="SLCO2B1" GraphId="fc85e" Type="GeneProduct"> <Comment>solute carrier organic anion transporter family, member 2B1 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11309</Comment> <Graphics CenterX="393.19438910410264" CenterY="1039.7072967173804" Width="80.0" Height="20.0" ZOrder="33689" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000015596"/> </DataNode> <DataNode TextLabel="CYP8B1" GraphId="cd425" Type="GeneProduct" GroupRef="be8fe"> <Comment>cytochrome P450, family 8, subfamily B, polypeptide 1 </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1582</Comment> <Graphics CenterX="516.0374458009" CenterY="926.3137059203392" Width="80.0" Height="20.0" ZOrder="33690" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000034106"/> </DataNode> <Interaction GraphId="c7b31"> <Graphics ZOrder="33623" LineThickness="1.0"> <Point X="578.8100219406099" Y="375.20286532346125" GraphRef="b32ae" RelX="0.0" RelY="-1.0"/> <Point X="348.84194590231226" Y="464.7465147341875" GraphRef="c4798" RelX="0.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d339d"> <Graphics ZOrder="33624" LineThickness="1.0"> <Point X="348.84194590231226" Y="195.21881343386295" GraphRef="f8ef6" RelX="0.0" RelY="-1.0"/> <Point X="348.84194590231226" Y="336.55819558834725" GraphRef="e1d8d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> 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<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"><bp:TERM>bile acid signaling pathway</bp:TERM><bp:ID>PW:0001093</bp:ID><bp:Ontology>Pathway Ontology</bp:Ontology></bp:openControlledVocabulary></Biopax> </Pathway>

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