Wishlist:N-glycan biosynthesis

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N-linked Glycosylation is one of the most important form of post-translational modification in eukaryotes. An earlier work in 1999 showed that at least 50% of the proteins known at the time were N-glycosylated; and the majority of the proteins in the secretory pathway (those that are exposed to the cell surface or in a vescicule) have this modification.

N-glycosylation is also important for the folding of the proteins in the secretory pathway, for cell-to-cell interactions, innate immunity, protein localization, and a lot of processes.

I am annotating this pathway for the reactome database: I have the list of the reactions involved, if anyone volunteer to translate this into the Wikipathways format, I will be glad to collaborate.

This pathway also is annotated in KEGG (http://www.genome.jp/dbget-bin/show_pathway?hsa00510), but the annotation I am doing is more extensive.

Wishlist:N-glycan biosynthesis

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-The most common form of modification for proteins in the secretory pathway is N-glycosilation.
+N-linked Glycosylation is one of the most important form of post-translational modification in eukaryotes.
-In this process, a sugar of 14 units is attached en bloc to the nascent protein, and successively modified to control the correct folding of the protein.
+An earlier work in 1999 showed that at least 50% of the proteins known at the time were N-glycosylated; and the majority of the proteins in the secretory pathway (those that are exposed to the cell surface or in a vescicule) have this modification.
-The biosynthesis of this 14 units N-glycan precursor is well conserved from bacterias to humans, and almost all the genes in this pathway are associated with diseases.
-This pathway is well annotated in KEGG (http://www.genome.jp/dbget-bin/show_pathway?hsa00510), and some genes involved have been curated on wikigenes (http://www.wikigenes.org).
+N-glycosylation is also important for the folding of the proteins in the secretory pathway, for cell-to-cell interactions, innate immunity, protein localization, and a lot of processes.
+I am annotating this pathway for the reactome database: I have the list of the reactions involved, if anyone volunteer to translate this into the Wikipathways format, I will be glad to collaborate.
+This pathway also is annotated in KEGG (http://www.genome.jp/dbget-bin/show_pathway?hsa00510), but the annotation I am doing is more extensive.