Selenium micronutrient network (Homo sapiens)

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3, 17, 74, 88, 99...17121138, 12314522, 145, 239, 265120120, 234, 26212072, 22098, 170, 2025, 6724216, 134, 153, 2623772Tryptophan metabolismOther proteinsSelenoproteinsSelenium statusLEGENDBindingMicronutrientsReactionMetabolitesProstaglandins metabolismCofactor conversionStimulationStatusis composed ofCatalysisMetabolic stressOxidative stressLeukotriene metabolismEnzymesProcess or metabolism involved in Se PathwayTranscription factorNegative EffectNecessary stimulationOverarching processInhibitionBiomarker forConversionInflammation and immune responseFrom intracellular part to the plasmaCleavageProtein tyrosine nitrationCofactorsCa++ metabolismLipoprotein melabolismIntracellularER protein folding NAD+ metabolismGlutathione metabolismFolate metabolismPlasmaThromboxane A2COX1F2-Isoprostanea-TocopherolPGF2aPGE1PGF2aPGE2RELANFkB2PGH3a-TocopherolCOX2PGD2Lipoxin B4EPA (n-3)EPA (n-3)PGE3PGG2Arachidonic acidNFkB1F2-IsoprostaneLipoxin A4PGD2Arachidonic acidThromboxane B2PGH2Linoleic acidLipoxin A4PGI2Linoleic acidLipoxin B4PGE2PGI2Thromboxane B221289, 165, 212218109, 212911658, 2448, 244115, 21278, 2281832282128, 43, 111, 183, 24414, 86, 101, 161, 1911653, 14, 43, 86, 91...4321811112, 5811122843, 91, 176, 22814, 86, 101, 161, 191212212218103, 212212228218Kynurenine220MTR194, 211TRXR1CBS159, 194IodineIodine206206KMO2205-HETEThyroxine (T4)15-HETER-Triiodothyronine (rT3)Triiodothyronine (T3)Triiodothyronine (T3)5,6-Epoxytetraene15-HETE5-HPETEThyroxine (T4)5-HETER-Triiodothyronine (rT3)77, 99, 183206, 22277, 99, 183151, 222183, 218151, 222206, 222151, 22277, 99, 183218183206, 222NADP+CatalaseMPOMPO2, 149, 164, 2042, 149, 164, 20424, 120Uric acid69, 123CysteineGGT1231GPX 4TRXR2Xantine oxidase69, 169PRDX5H2O2ALOX15BALOX53, 88, 161, 218, 230183, 256CopperUric acid69, 123Vitamin B12148, 2685,10-Methylene-THFSelR216, 234Tryptophan72, 2205-methyl-THFSOD3PRDX1RFK217H2OGPX 3NiacinamideCTH194PNPO235Heme24, 61, 89, 120, 159NADPHLipoic acid265ManganeseFAD100Methionine sulfoxide234Dehydroascorbic acid25, 239Leukotriene A433, 245NADPHFAD100THFHydroxykynurenine220Folic acid211NADP+NADPHSeleniumSelenium208208Sep15SelK134, 192, 262132GPX 6GSH184Nicotinamidase72Calcium33Methionine234ManganeseNADPHFolic acid211FMN100SelenophosphateSelenocysteineSelenide22, 22222, 22222, 222CysteineLeukotriene C4Leukotriene C433, 231GPX 317Dehydroascorbic acid239GPX 2SelP10Trx-S2145, 239, 265Ascorbic acid25Lipoic acid265PRDX4GPX 1NADP+HomocysteineRNSROS16, 25, 37, 50, 54...120, 242NADPHVitamin B12148, 268MTHFR211HomocysteineDIO2SPS2SelVSelHSelPSelSDIO1SelTSelMSelNDIO3SelOSelI37, 193808080, 98, 202153, 181, 19580222, 229206, 222, 22610, 117, 12180, 17016, 54, 225206, 222206, 222SOD1Pyridoxal 5'-phosphate220SerineIron33HypoxanthinePRDX3 GSR251VLDL-TAGVLDLoxLDLHDL-CTAGHDL/APOA1APOA1oxLDLLDLAPOA1-NO2TyrHDLHDL/SAASAA4FMNHDL-CSAA2APOA1ABCA1SAA3CholesterolTAGSAA1APOBACTVLDL/APOBLDLAPOBHDLLDLRACTCholesterolVLDL-TAGVLDLSRB15, 1518218229, 67, 122, 149, 2275, 1584, 1745172, 1825182182529, 67, 75, 116, 122...5, 15, 8736, 55, 84, 96, 174...555, 15182172, 182182587529, 67, 75, 116, 122...529, 67, 122, 149, 227100197536, 55, 84, 96, 174...5, 155, 87182O2Pyridoxal 5'-phosphate220FAD100PRDX2 ADPLeukotriene D4Leukotriene D4231CopperChlorineChlorineCystathionineFAD100SOD2Dihydrolipoate113, 265SerineNADP+ATPZincNADP+GSSGNADPHZincNiacinLeukotriene B4Leukotriene B424533, 245Quinolinic Acid72, 220PMPHOClNONOO3HNO2NO2164, 204164, 204NADP+GSH37, 184, 245IL6TNFaIL1BIL1BIFNgIFNgIL6FLAPTNFa226121, 226195226185, 195195121, 185, 195226230SelW142, 175, 184Riboflavin140SOD338TRXR1145Ascorbate25, 239O2 · –XanthineCalcium33Kynureninase220Methionine234ADPTrx-(SH)2145, 265NitrotyrosineNitrotyrosineONOO–/ONOOH242242ATPLeukotriene E4Leukotriene E4231Leukotriene F462, 231Iron33HypoxanthineTRXR3FLAD119, 217Ascorbic acid25, 101, 191


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  244. Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A; ''Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  245. Proctor PH.; ''Free radicals, uric acid, and human disease.''; Free Radic Biol Med., 1996 PubMed Europe PMC Scholia
  246. Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, Cooperman BS, Douglas SD, Rubin H; ''Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin.''; J Immunol, 1991 PubMed Europe PMC Scholia
  247. Schafer BL, Bishop RW, Kratunis VJ, Kalinowski SS, Mosley ST, Gibson KM, Tanaka RD; ''Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.''; J Biol Chem, 1992 PubMed Europe PMC Scholia
  248. Wu D, Mura C, Beharka AA, Han SN, Paulson KE, Hwang D, Meydani SN; ''Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E.''; Am J Physiol, 1998 PubMed Europe PMC Scholia
  249. Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML.; ''Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.''; Nat Struct Biol., 2002 PubMed Europe PMC Scholia
  250. Deo AK, Bandiera SM; ''Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid.''; Drug Metab Dispos, 2008 PubMed Europe PMC Scholia
  251. Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJ; ''Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis.''; Am J Hum Genet, 2001 PubMed Europe PMC Scholia
  252. Yamauchi Y, Reid PC, Sperry JB, Furukawa K, Takeya M, Chang CC, Chang TY; ''Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  253. Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N, Yamamoto M, Kumasaka T, Miyano M, Kai Y, Urade Y; ''Mechanism of metal activation of human hematopoietic prostaglandin D synthase.''; Nat Struct Biol, 2003 PubMed Europe PMC Scholia
  254. Hansel A, Heinemann SH, Hoshi T; ''Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation.''; Biochim Biophys Acta, 2005 PubMed Europe PMC Scholia
  255. Bleys J, Navas-Acien A, Guallar E; ''Serum selenium and diabetes in U.S. adults.''; Diabetes Care, 2007 PubMed Europe PMC Scholia
  256. Neumann D, Kollewe C, Resch K, Martin MU.; ''The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia
  257. Minkes M, Stanford N, Chi MM, Roth GJ, Raz A, Needleman P, Majerus PW; ''Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.''; J Clin Invest, 1977 PubMed Europe PMC Scholia
  258. Janciauskiene S, Wright HT; ''Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.''; Bioessays, 1998 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
125000view06:55, 12 January 2023SusanRemoved fill colors for the pathways listed
123380view11:44, 21 July 2022DeSlRemoved not UTF-8 encoded symbols for Hyperoxid
121694view03:28, 26 February 2022EweitzFix gene symbol
120903view14:04, 29 January 2022EgonwReplaced an old HMDB identifier with the current one
118387view13:57, 27 May 2021Marvin M2removed empty refs
117822view14:56, 22 May 2021EweitzModified title
107118view14:19, 17 September 2019MaintBotChEBI identifier normalization
106694view13:04, 17 September 2019MaintBotHMDB identifier normalization
106489view21:41, 4 September 2019KhanspersModified description
105808view22:53, 15 August 2019KhanspersModified description
105140view15:25, 10 July 2019DeSlConverted unconnected lines into graphical lines (if applicable).
105136view14:54, 10 July 2019DeSlUpdated Fibrinogen as complex with 3 subunits, changed fibrin datanode type from protein to metabolite.
98241view14:04, 14 August 2018EgonwReplace a PubChem SID with a Wikidata ID (which has more links out).
96720view21:55, 30 March 2018AlexanderPicoModified description
96318view09:09, 8 March 2018Mkutmonremove outdated pathway attributes
96278view08:13, 5 March 2018EgonwConverted interactions to regular arrows, which were not mim:conversions.
96250view14:07, 2 March 2018EgonwFixed a character encoding issue.
96249view14:06, 2 March 2018EgonwIt had the PubChem CID from the start, but that entry is not the protein fibrin, but a small compound. I now took the Wikidata entry matching the proper Wikipedia page.
94185view13:59, 25 August 2017Mkutmonadded missing metabolite identifiers
94106view09:54, 21 August 2017DeSlConnected 3 more unconnected lines.
94105view09:52, 21 August 2017DeSlConnected unconnected lines.
93691view15:50, 9 August 2017DeSlModified description
88908view08:53, 17 August 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
85060view11:16, 10 April 2016Egonw
82705view08:55, 23 October 2015EgonwMissed one oxLDL :(
82703view08:43, 23 October 2015EgonwoxLDL has a separate identifier.
82689view15:29, 22 October 2015EgonwRemoved HMDB00464 from iodine and iron data nodes.
79870view14:46, 21 April 2015Mkutmonremoved invalid annotation for "Fibrinogen" (Database: Other)
78776view23:23, 26 January 2015AlexanderPicoreplacing legend datanodes with shapes
78775view23:15, 26 January 2015AlexanderPicoreplacing legend datanode with shape
73505view23:16, 29 January 2014KhanspersModified title
73504view23:14, 29 January 2014KhanspersModified title
73357view04:57, 23 January 2014MaintBotfixed character representation of hyphen in gpml
72365view09:35, 13 November 2013EgonwFixed the type of two proteins.
71706view19:58, 17 October 2013MaintBotUpdated data sources
70119view19:19, 12 July 2013MaintBotupdated to 2013 schema
68043view11:14, 29 June 2013EgonwAdded two missing metabolite identifiers.
68041view11:08, 29 June 2013EgonwUndo revision 68036 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
68040view11:07, 29 June 2013EgonwUndo revision 68037 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
68039view11:06, 29 June 2013EgonwUndo revision 68038 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
68038view11:02, 29 June 2013EgonwRemoved a few empty, unlinked gene product data nodes.
68037view10:58, 29 June 2013EgonwRemoved an empty unlinked 'protein'.
68036view10:57, 29 June 2013EgonwRemoved an empty unlinked 'metabolite'.
68035view10:49, 29 June 2013EgonwFixed EC number data source.
61689view22:06, 16 April 2013MaintBotremoved data source without identifer
56489view09:45, 8 January 2013EgonwFixed DataNode @Type from Metabolite to Protein for those with an Entrez Gene identifier.
54708view14:04, 7 December 2012AndraRDF Tidy
48242view06:08, 17 May 2012MaintBotUpdating PubChem xrefs
48216view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45021view18:39, 6 October 2011ThomasOntology Term : 'selenoamino acid metabolic pathway' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment
GeneProduct
15-HETEMetaboliteHMDB03876 (HMDB) 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
5,10-Methylene-THFMetaboliteHMDB01533 (HMDB) 5,10-Methylenetetrahydrofolate
5,6-EpoxytetraeneMetaboliteC14815 (Kegg Compound)
5-HETEMetaboliteHMDB11134 (HMDB) 5-hydroxyeicosatetraenoic acid
5-HPETEMetaboliteHMDB01193 (HMDB) 5(S)-Hydroperoxyeicosatetraenoic acid
5-methyl-THFMetaboliteHMDB01396 (HMDB) 5-methyltetrahydrofolate
ABCA1Protein19 (Entrez Gene) ATP-binding cassette, sub-family A (ABC1), member 1
ACTProtein12 (Entrez Gene)
  • alpha-1-antichymotrypsin
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
ADPMetaboliteHMDB01341 (HMDB) Adenosine diphosphate
ALOX15BProtein247 (Entrez Gene)
  • EC 1.13.11.33
  • arachidonate 15-lipoxygenase, type B
ALOX5Protein240 (Entrez Gene)
  • EC 1.13.11.34
  • arachidonate 5-lipoxygenase
APOA1-NO2TyrProtein335 (Entrez Gene) Nitrotyrosinated apolipoprotein A-I
APOA1Protein335 (Entrez Gene) apolipoprotein A-I
APOBProtein338 (Entrez Gene) apolipoprotein B
ATPMetaboliteHMDB00538 (HMDB) Adenosine triphosphate
Arachidonic acidMetaboliteHMDB01043 (HMDB)
AscorbateMetabolite38290 (ChEBI)
Ascorbic acidMetabolite29073 (ChEBI)
CBSProtein875 (Entrez Gene)
  • EC 4.2.1.22
  • cystathionine-beta-synthase
COX1Protein5742 (Entrez Gene)
  • EC 1.14.99.1
  • Cyclooxygenase 1
  • COX-1 constitutive
COX2Protein5743 (Entrez Gene)
  • EC 1.14.99.1
  • Cyclooxygenase 2
  • COX-2 inducible
CTHProtein1491 (Entrez Gene)
  • EC 4.4.1.1
  • cystathionase
CalciumMetaboliteHMDB00464 (HMDB)
CatalaseProtein847 (Entrez Gene) EC 1.11.1.6
ChlorineMetaboliteHMDB00492 (HMDB)
CholesterolMetaboliteHMDB00067 (HMDB)
CopperMetaboliteHMDB00657 (HMDB)
CystathionineMetaboliteHMDB00099 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
DIO1Protein1733 (Entrez Gene)
  • EC 1.97.1.10
  • Selenoprotein-deiodinase, iodothyronine, type I
DIO2Protein1734 (Entrez Gene)
  • EC 1.97.1.10
  • Selenoprotein-deiodinase, iodothyronine, type II
DIO3Protein1735 (Entrez Gene)
  • EC 1.97.1.11
  • Selenoprotein-deiodinase, iodothyronine type III
Dehydroascorbic acidMetabolite17242 (ChEBI)
DihydrolipoateMetaboliteHMDB12210 (HMDB)
EPA (n-3)MetaboliteHMDB01999 (HMDB) Eicosapentaenoic acid
F2-IsoprostaneMetabolite53788444 (PubChem)
FADMetaboliteHMDB01248 (HMDB) Flavin adenine dinucleotide
FLAD1Protein80308 (Entrez Gene)
  • EC 2.7.7.2
  • FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
FLAPProtein241 (Entrez Gene) arachidonate 5-lipoxygenase-activating protein
FMNMetaboliteHMDB01520 (HMDB) Flavin Mononucleotide
Folic acidMetaboliteHMDB00121 (HMDB)
GGT1Protein2678 (Entrez Gene)
  • EC 2.3.2.2
  • gamma-glutamyltransferase 1
GPX 1Protein2876 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 1
GPX 2Protein2877 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 2
GPX 3Protein2878 (Entrez Gene) Selenoprotein-glutathione peroxidase 3
GPX 4Protein2879 (Entrez Gene)
  • EC 1.11.1.12
  • Selenoprotein-glutathione peroxidase 4
GPX 6Protein257202 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 6
GSHMetaboliteHMDB00125 (HMDB) Glutathione
GSRProtein2936 (Entrez Gene)
  • EC 1.8.1.7
  • glutathione reductase
GSSGMetaboliteHMDB00656 (HMDB) Glutathione disulfide
H2O2MetaboliteHMDB03125 (HMDB) Hydrogen peroxide
H2OMetaboliteHMDB02111 (HMDB) Glutathione disulfide
HDL-CMetabolite47775 (ChEBI)
  • high-density lipoprotein cholesterol
  • Cholesterol transport
HDL/APOA1Metabolite39025 (ChEBI)
  • high-density lipoprotein
  • ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles
HDL/SAAMetabolite39025 (ChEBI)
  • high-density lipoprotein
  • SAA circulates in plasma as a constituent of high density lipoproteins (HDL).
HDLMetabolite39025 (ChEBI) high-density lipoprotein
HNO2Metabolite25567 (ChEBI) Nitrous acid
HOClMetaboliteHMDB01050 (HMDB) Hypochlorite
HemeMetaboliteHMDB03178 (HMDB)
HomocysteineMetaboliteHMDB00742 (HMDB)
HydroxykynurenineMetaboliteHMDB00732 (HMDB)
HypoxanthineMetaboliteHMDB00157 (HMDB)
IFNgProtein3458 (Entrez Gene) interferon, gamma
IL1BProtein3553 (Entrez Gene) interleukin 1, beta
IL6Protein3569 (Entrez Gene) interleukin 6 (interferon, beta 2)
IodineMetaboliteHMDB00464 (HMDB)
IronMetaboliteHMDB00464 (HMDB)
IronMetaboliteHMDB00692 (HMDB)
KMOProtein8564 (Entrez Gene)
  • EC 1.14.13.9
  • kynurenine 3-hydroxylase
KynureninaseProtein8942 (Entrez Gene) EC 3.7.1.3
KynurenineMetaboliteHMDB00684 (HMDB)
LDLMetabolite39026 (ChEBI) low-density lipoprotein
LDLRProtein3949 (Entrez Gene) low density lipoprotein receptor
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
Leukotriene F4MetaboliteHMDB06465 (HMDB)
Linoleic acidMetaboliteHMDB00673 (HMDB)
Lipoic acidMetaboliteHMDB01451 (HMDB)
Lipoxin A4MetaboliteHMDB04385 (HMDB)
Lipoxin B4MetaboliteHMDB05082 (HMDB)
MPOProtein4353 (Entrez Gene)
  • EC 1.11.1.7
  • Myeloperoxidase
MTHFRProtein4524 (Entrez Gene)
  • EC 1.5.1.20
  • 5,10-methylenetetrahydrofolate reductase
MTRProtein4548 (Entrez Gene)
  • EC 2.1.1.13
  • 5-methyltetrahydrofolate-homocysteine methyltransferase
ManganeseMetaboliteHMDB01333 (HMDB)
Methionine sulfoxideMetaboliteHMDB02005 (HMDB)
MethionineMetaboliteHMDB00696 (HMDB)
NADP+MetaboliteHMDB00217 (HMDB) Nicotinamide adenine dinucleotide phosphate-Oxidized
NADPHMetaboliteHMDB00221 (HMDB) Nicotinamide adenine dinucleotide phosphate-Reduced
NFkB1GeneProduct4790 (Entrez Gene) nuclear factor NF-kappa-B p50 subunit
NFkB2GeneProduct4791 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
NO2Metabolite33101 (ChEBI) Nitrogen dioxide
NOMetaboliteHMDB03378 (HMDB) Nitric oxide
NiacinMetaboliteHMDB01488 (HMDB)
NiacinamideMetaboliteHMDB01406 (HMDB)
NicotinamidaseProteinEC 3.5.1.19 (Other) Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3 GO:0008936
NitrotyrosineMetaboliteHMDB01904 (HMDB)
O2 · –MetaboliteHMDB02168 (HMDB) Superoxide
O2MetaboliteHMDB01377 (HMDB)
O3Metabolite25812 (ChEBI) ozone
ONOO–/ONOOHMetaboliteHMDB02179 (HMDB) Peroxynitrite
PGD2MetaboliteHMDB01403 (HMDB) Prostaglandin D2
PGE1MetaboliteHMDB01442 (HMDB) Prostaglandin E1
PGE2MetaboliteHMDB01220 (HMDB) Prostaglandin E2
PGE3MetaboliteHMDB02664 (HMDB) Prostaglandin E3
PGF2aMetaboliteHMDB01139 (HMDB) Prostaglandin F2a
PGG2MetaboliteHMDB03235 (HMDB) Prostaglandin G2
PGH2MetaboliteHMDB01381 (HMDB) Prostaglandin H2
PGH3MetaboliteProstaglandin H3
PGI2MetaboliteHMDB01335 (HMDB) Prostaglandin I2
PMPMetaboliteHMDB01555 (HMDB) Pyridoxamine 5'-phosphate
PNPOProtein55163 (Entrez Gene)
  • EC 1.4.3.5
  • pyridoxamine 5'-phosphate oxidase
PRDX1Protein5052 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 1
PRDX2 Protein7001 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 2
PRDX3 Protein10935 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 3
PRDX4Protein10549 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 4
PRDX5Protein25824 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 5
Pyridoxal 5'-phosphateMetaboliteHMDB01491 (HMDB)
Quinolinic AcidMetaboliteHMDB00232 (HMDB)
R-Triiodothyronine (rT3)Metabolite28774 (ChEBI) Reverse triiodothyronine
RELAGeneProduct5970 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
RFKProtein55312 (Entrez Gene)
  • EC 2.7.1.26
  • riboflavin kinase
RNSMetabolite
  • reactive nitrogen species
  • http://en.wikipedia.org/wiki/Reactive_nitrogen_species
ROSMetabolite26523 (ChEBI)
  • reactive oxygen species
  • http://en.wikipedia.org/wiki/Reactive_Oxygen_Species
RiboflavinMetaboliteHMDB00244 (HMDB)
SAA1Protein6288 (Entrez Gene) serum amyloid A1
SAA2Protein6289 (Entrez Gene) serum amyloid A2
SAA3Protein6290 (Entrez Gene) serum amyloid A3 pseudogene
SAA4Protein6291 (Entrez Gene) serum amyloid A4, constitutive
SOD1Protein6647 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 1, soluble
SOD2Protein6648 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 2, mitochondrial
SOD3Protein6649 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 3, extracellular
SPS2Protein22928 (Entrez Gene)
  • EC2.7.9.3
  • Selenoprotein-selenophosphate synthetase 2
SRB1Protein949 (Entrez Gene) scavenger receptor class B, member 1
SelHProtein280636 (Entrez Gene) Selenoprotein-selenoprotein H-chromosome 11 open reading frame 31
SelIProtein85465 (Entrez Gene)
  • Selenoprotein-selenoprotein I
  • Unknown function
SelKProtein58515 (Entrez Gene) Selenoprotein-selenoprotein K
SelMProtein140606 (Entrez Gene) Selenoprotein-selenoprotein M
SelNProtein57190 (Entrez Gene) Selenoprotein-selenoprotein N, 1
SelOProtein83642 (Entrez Gene)
  • Selenoprotein-selenoprotein O
  • Unknown function
SelPProtein6414 (Entrez Gene) Selenoprotein-selenoprotein P
SelRMetabolite51734 (Entrez Gene)
  • EC 1.8.4.-
  • Selenoprotein-selenoprotein X
SelSProtein55829 (Entrez Gene) Selenoprotein-selenoprotein S
SelTProtein51714 (Entrez Gene) Selenoprotein-selenoprotein T
SelVProtein348303 (Entrez Gene)
  • Selenoprotein-selenoprotein V
  • Unknown function
SelWMetabolite6415 (Entrez Gene) Selenoprotein-selenoprotein W
SelenideMetabolite15076 (ChEBI)
SeleniumMetaboliteHMDB01349 (PubChem)
SelenocysteineMetaboliteHMDB03288 (HMDB)
SelenophosphateMetabolite16144 (ChEBI)
Sep15Protein9403 (Entrez Gene) Selenoprotein-15 kDa selenoprotein
SerineMetaboliteHMDB00187 (HMDB)
TAGMetabolite17855 (ChEBI)
  • Triglyceride
  • Triacylglycerol
THFMetaboliteHMDB01846 (HMDB) Tetrahydrofolic acid
TNFaProtein7124 (Entrez Gene) tumor necrosis factor (TNF superfamily, member 2)
TRXR1Metabolite7296 (Entrez Gene) Selenoprotein-thioredoxin reductase 1
TRXR2Protein10587 (Entrez Gene)
  • EC 1.8.1.9
  • Selenoprotein-thioredoxin reductase 2
TRXR3Protein114112 (Entrez Gene)
  • EC 1.8.1.9
  • Selenoprotein-thioredoxin reductase 3
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
Thyroxine (T4)Metabolite30660 (ChEBI)
Triiodothyronine (T3)Metabolite18258 (ChEBI)
Trx-(SH)2Protein7295 (Entrez Gene) reduced thioredoxin
Trx-S2Protein7295 (Entrez Gene) oxidized thioredoxin
TryptophanMetaboliteHMDB00929 (HMDB)
Uric acidMetaboliteHMDB00289 (HMDB)
VLDL-TAGMetabolite47776 (ChEBI)
  • very-low-density lipoprotein-triglyceride
  • Triglyceride transport
VLDL/APOBMetabolite39027 (ChEBI)
  • very-low-density lipoprotein
  • The VLDL is produced in the liver, contains one molecule of apoB100
VLDLMetabolite39027 (ChEBI) very-low-density lipoprotein
Vitamin B12MetaboliteHMDB02174 (HMDB)
XanthineMetaboliteHMDB00292 (HMDB)
Xantine oxidaseProtein7498 (Entrez Gene)
  • EC 1.17.3.2
  • http://en.wikipedia.org/wiki/Xanthine_oxidase
ZincMetaboliteHMDB01303 (HMDB)
a-TocopherolMetaboliteHMDB01893 (HMDB)
oxLDLMetabolite39026 (ChEBI) oxidized low-density lipoprotein

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP15"
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