Amyotrophic lateral sclerosis (ALS) (Homo sapiens)

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Endoplasmic reticulum (ER)MitochondriaAstrocyteShould this be calcineurin complex or protein phosphatase 3, regulatory subunit?Elevated glutamatelevelsDNA damageAggregatesMKK3DAXXNOCYTCp38ASK1NOReactive Oxygen Species (ROS)TNFalphaCa2+MKK6Presynaptic neuronMicroglial cellMotor neuronNOL-ArginineONOO-EAAT2L-Glutamic acidL-Glutamic acidP53p53 signalingpathwayNeuron deathAPAF1CASP3CASP9ApoptosisActivationcalcineurin complexL-Glutamic acidsynaptic transmission, glutamatergicIncrease incytosolic Ca2+Ca2+DERL1_HUMANAccumulation ofmisfolded proteinsER stressATP depletionFall in mitochondrialmembrane potentialIncreased ROSDisturbance ofmitochondrial respirationMitochondrialdysfunctionLow Ca2+ bufferingcapacityCa2+CASP1BID_HUMANSOD1TOM40_HUMANBIM-BCL-2 complexBIM-BCL-xl complexBAXBADproteasome complexUbiquitin proteosomedysfunctionApoptosisCASP12MAP3K5TNFalphaTNFRGRIA1NONO


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Flomen R, Makoff A; ''Increased RNA editing in EAAT2 pre-mRNA from amyotrophic lateral sclerosis patients: involvement of a cryptic polyadenylation site.''; Neurosci Lett, 2011 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128125view13:18, 27 January 2024EweitzOntology Term : 'astrocyte' added !
128124view13:18, 27 January 2024EweitzOntology Term : 'neuron' added !
128123view13:17, 27 January 2024EweitzOntology Term : 'microglial cell' added !
128122view13:16, 27 January 2024EweitzRemove excessive padding
128121view13:15, 27 January 2024EweitzEconomize legend position
128120view13:14, 27 January 2024EweitzRefine layout, standardize case
113794view09:07, 24 November 2020Finterlysmall graphical update
113792view08:56, 24 November 2020Finterlymake pathways clickable
113789view17:09, 23 November 2020FinterlySmall graphical update and fixed links
109207view21:31, 26 February 2020KhanspersAdded mutation states
108062view13:19, 27 November 2019FehrhartOntology Term : 'amyotrophic lateral sclerosis' added !
106714view13:15, 17 September 2019MaintBotHMDB identifier normalization
105880view04:52, 16 August 2019KhanspersModified description
105527view06:00, 9 August 2019KhanspersModified description
96316view09:07, 8 March 2018Mkutmonremove old WP category
96258view16:25, 2 March 2018EgonwOntology Term : 'disease pathway' added !
96111view11:20, 18 February 2018EgonwReplaced mim-conversion with arrow for things that are not conversions.
96110view11:13, 18 February 2018EgonwMade a number of labels readable (again)
96105view14:38, 16 February 2018DeSlChanged MIMconversion to arrow between gene and metabolite
85186view14:39, 23 April 2016EgonwReplaced a mim-conversion with Arrow.
85057view10:52, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
85049view10:22, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
84415view21:47, 23 February 2016AlexanderPicoQuick edit to datanode annotation or property
79862view12:17, 21 April 2015Mkutmonfixed linkout to wikipedia for ROS
75221view21:48, 9 May 2014Khansperschnaged DNA from gene product to label
72245view20:53, 29 October 2013Khansperschanged pathway node xrefs from GO to WP
72040view13:49, 24 October 2013SusanConnected lines
71227view21:29, 15 October 2013MaintBotUpdated UniProt/TrEMBL data source
71226view21:21, 15 October 2013MaintBotUpdated KEGG xrefs
70574view18:04, 14 August 2013MaintBotFixed xref for p53
70573view17:59, 14 August 2013MaintBotFixed Wikipedia link for ROS
70572view15:05, 13 August 2013MetalmephistoAttempting to add ID for ROS
70571view15:00, 13 August 2013MetalmephistoChanged Metabolite ID
64563view17:47, 29 May 2013Khanspersadded lit ref
64292view04:22, 23 May 2013Khanspersadded pathway node
64291view04:09, 23 May 2013KhanspersModified description
64290view04:00, 23 May 2013Khanspersfinal draft
64289view03:56, 23 May 2013Khansperswork in progress
64288view03:52, 23 May 2013Khansperswork in progress
64271view20:45, 22 May 2013KhanspersPeriodical save, work in progress
64270view20:44, 22 May 2013KhanspersSpecify description
64269view20:35, 22 May 2013KhanspersPeriodical save, work in progress
64260view19:21, 22 May 2013KhanspersSpecify description
64259view19:17, 22 May 2013Khansperswork in progress
64256view19:09, 22 May 2013KhanspersPeriodical save, work in progress
64201view21:40, 21 May 2013Khansperswork in progress
64200view21:32, 21 May 2013Khansperswork in progress
64199view21:25, 21 May 2013KhanspersPeriodical save, work in progress
64198view21:15, 21 May 2013KhanspersPeriodical save, work in progress
64197view21:04, 21 May 2013KhanspersPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APAF1GeneProduct317 (Entrez Gene)
ASK1GeneProduct4217 (Entrez Gene)
ApoptosisPathwayWP254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BID_HUMANProteinP55957 (Uniprot/TrEMBL)
BIM-BCL-2 complexProteinGO:0097141 (GeneOntology)
BIM-BCL-xl complexProteinGO:0097140 (GeneOntology)
CASP12GeneProductENSG00000204403 (Ensembl)
CASP1GeneProduct834 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CYTCProteinP01034 (Uniprot/TrEMBL)
Ca2+MetaboliteC00076 (Kegg Compound)
Ca2+MetaboliteHMDB00464 (HMDB)
DAXXGeneProduct1616 (Entrez Gene)
DERL1_HUMANProteinQ9BUN8 (Uniprot/TrEMBL)
EAAT2ProteinP43004 (Uniprot/TrEMBL)
GRIA1Protein2890 (Entrez Gene)
L-ArginineMetaboliteHMDB00517 (HMDB)
L-Glutamic acidMetaboliteHMDB00148 (HMDB)
MAP3K5GeneProductENSG00000197442 (Ensembl)
MKK3GeneProduct5605 (Entrez Gene)
MKK6GeneProduct5608 (Entrez Gene)
NOMetaboliteHMDB03378 (HMDB)
ONOO-MetaboliteHMDB02179 (HMDB)
P53ProteinP53 (Uniprot/TrEMBL)
Reactive Oxygen Species (ROS)Metabolite
SOD1GeneProduct6647 (Entrez Gene)
TNFRGeneProduct7132 (Entrez Gene)
TNFalphaGeneProduct7124 (Entrez Gene)
TOM40_HUMANProteinO96008 (Uniprot/TrEMBL)
calcineurin complexProteinGO:0005955 (GeneOntology)
p38GeneProduct1432 (Entrez Gene)
p53 signaling pathwayPathwayWP707 (WikiPathways)
proteasome complexProteinGO:0000502 (GeneOntology)
synaptic

transmission,

glutamatergic		PathwayGO:0035249 (GeneOntology)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2447"
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