Nephrotoxcicity adverse outcome pathway (Homo sapiens)

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Cytokines and inflammatory responseKE1194: Increase, DNA DamagehOCT2 activationKE1262: ApoptosisOverview of proinflammatory and profibrotic mediatorsApoptosis modulation and signalingTLR4 signaling and toleranceKE1633: Increase in inflammationOxidative damage responseInflammatory response pathwayKE1815: Activation of ER stressApoptosis modulation and signalingKE1115: Increased, Reactive oygen speciesDNA repair pathways, full networkKE1923: Altered gene expression, P53 dependent apoptosis pathwayFerroptosisRIPK1-mediated regulated necrosisElectron transport chain: OXPHOS system in mitochondriaDNA damage responseKE1968: Increase, Mitochondrial DysfunctionAutophagyp53 transcriptional gene networkToll-like receptor signaling pathwayUnfolded protein responsehCRT1 activationOxidative stress responseKE1496: Increased, secretion of proinflammatory mediatorsKE1848: Toll Like Receptor (TLR) DysregulationKE55: Cell injury/death


Description

Adverse outcome pathway depicting events of nephrotoxicity leading to tubular cell injury and death. Damaga can happen through induction of DNA damage, activation of apoptosis through cytosplasmic organelle stress, and inflammation.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Perazella MA, Rosner MH; ''Drug-Induced Acute Kidney Injury.''; Clin J Am Soc Nephrol, 2022 PubMed Europe PMC Scholia
  2. Manohar S, Leung N; ''Cisplatin nephrotoxicity: a review of the literature.''; J Nephrol, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134519view12:43, 22 July 2024EweitzStandardize case
129363view09:38, 27 March 2024MkutmonOntology Term : 'disease pathway' added !
123080view17:34, 26 June 2022JuliajohnssonChanged arrow
123079view14:10, 24 June 2022Juliajohnssonannotated key event
123078view14:03, 24 June 2022JuliajohnssonAdded key event
122984view10:54, 9 June 2022Juliajohnssonfixed pathway interaction
122918view21:29, 2 June 2022JuliajohnssonAdded gene name
122752view10:33, 9 May 2022JuliajohnssonAdded gene name.
122712view13:38, 4 May 2022JuliajohnssonFixed interactions
122707view13:21, 4 May 2022JuliajohnssonChnaged pathway node to event node
122706view13:16, 4 May 2022JuliajohnssonChanged empty type columns to events
122700view14:50, 3 May 2022Marvin M2created event node
122696view14:02, 3 May 2022JuliajohnssonModified description
122695view13:54, 3 May 2022JuliajohnssonAdded literature and fixed interactions.
122689view14:46, 2 May 2022JuliajohnssonOntology Term : 'CL:1000497' removed !
122688view14:46, 2 May 2022JuliajohnssonOntology Term : 'DOID:0050855' removed !
122687view14:46, 2 May 2022JuliajohnssonOntology Term : 'DOID:557' removed !
122686view14:44, 2 May 2022JuliajohnssonOntology Term : 'renal fibrosis' added !
122685view14:40, 2 May 2022JuliajohnssonOntology Term : 'kidney disease' added !
122684view14:36, 2 May 2022JuliajohnssonOntology Term : 'chronic kidney disease' added !
122683view14:35, 2 May 2022JuliajohnssonOntology Term : 'kidney tubule cell' added !
122682view14:34, 2 May 2022JuliajohnssonOntology Term : 'acute kidney tubular necrosis' added !
122681view14:31, 2 May 2022JuliajohnssonModified description
122680view11:04, 2 May 2022Juliajohnssonupdated one key event
122679view10:52, 2 May 2022Juliajohnssonupdated key events
122678view10:30, 2 May 2022JuliajohnssonOntology Term : 'kidney cell' added !
122677view10:29, 2 May 2022JuliajohnssonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Apoptosis modulation and signalingPathwayWP1772 (WikiPathways)
AutophagyPathwayWP4923 (WikiPathways)
Cytokines and inflammatory responsePathwayWP530 (WikiPathways)
DNA damage responsePathwayWP707 (WikiPathways)
DNA repair pathways, full networkPathwayWP4946 (WikiPathways)
Electron transport chain: OXPHOS system in mitochondriaPathwayWP111 (WikiPathways)
FerroptosisPathwayWP4313 (WikiPathways)
Inflammatory response pathwayPathwayWP453 (WikiPathways)
KE1115: Increased, Reactive oygen species1115 (AOP-Wiki KE)
KE1194: Increase, DNA Damage1194 (AOP-Wiki KE)
KE1262: ApoptosisPathway1262 (AOP-Wiki KE)
KE1496: Increased, secretion of proinflammatory mediators1496 (AOP-Wiki KE)
KE1633: Increase in inflammation1633 (AOP-Wiki KE)
KE1815: Activation of ER stress1815 (AOP-Wiki KE)
KE1848: Toll Like Receptor (TLR) Dysregulation1848 (AOP-Wiki KE)
KE1923: Altered gene expression, P53 dependent apoptosis pathway1923 (AOP-Wiki KE)
KE1968: Increase, Mitochondrial Dysfunction1968 (AOP-Wiki KE)
KE55: Cell injury/death55 (AOP-Wiki KE)
Overview of proinflammatory and profibrotic mediatorsPathwayWP5095 (WikiPathways)
Oxidative damage responsePathwayWP3941 (WikiPathways)
Oxidative stress responsePathwayWP408 (WikiPathways)
RIPK1-mediated regulated necrosisPathwayWP5022 (WikiPathways)
TLR4 signaling and tolerancePathwayWP3851 (WikiPathways)
Toll-like receptor signaling pathwayPathwayWP75 (WikiPathways)
Unfolded protein responsePathwayWP4925 (WikiPathways)
hCRT1 activation
hOCT2 activation
p53 transcriptional gene networkPathwayWP4963 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5229"
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