BMP signaling and regulation (Bos taurus)

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"BMP signals are mediated by type I and II BMP receptors and their downstream molecules Smad1, 5 and 8. Phosphorylated Smad1, 5 and 8 proteins form a complex with Smad4 and then are translocated into the nucleus where they interact with other transcription factors, such as Runx2 in osteoblasts." (Chen 2004)

HomologyConvert 

This pathway was inferred from Homo sapiens pathway WP1425(74390) with a 100.0% conversion rate.