Farnesoid X receptor pathway (Bos taurus)

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21Bile acid detoxificationBile acid neosynthesisBile acid conjugationTranscriptionOtherBile acid & xenobiotics transport13131313NR1H434FXR ligandNR1H4RXRA34LigandGenesTATA boxNR1H434RXRALigandFXRENR1H434LigandRXRAUGT2B4SULT2A1SLC27A5SLC10A1CYP7A1NR0B21248FGF1925IRS2ABCB11BAATCYP3A412FKBP5UQCC2ABCB4NR0B2PPARGC1A48SLCO2B1CYP8B1FXR Target genes


Description

The farnesoid X receptor (FXR, a.k.a. NR1H4) is a nuclear receptor that responds to levels of bile acids present in the body and regulates many processes related to bile acids synthesis and transport.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2879(79602) with a 100.0% conversion rate.

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Bibliography

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  1. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed Europe PMC Scholia
  2. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH; ''AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.''; Chem Res Toxicol, 2007 PubMed Europe PMC Scholia
  3. Mimura J, Fujii-Kuriyama Y; ''Functional role of AhR in the expression of toxic effects by TCDD.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  4. Willson TM, Kliewer SA; ''PXR, CAR and drug metabolism.''; Nat Rev Drug Discov, 2002 PubMed Europe PMC Scholia
  5. Köhle C, Bock KW; ''Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.''; Biochem Pharmacol, 2007 PubMed Europe PMC Scholia
  6. ''''; , PubMed Europe PMC Scholia
  7. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  8. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  9. Timsit YE, Negishi M; ''CAR and PXR: the xenobiotic-sensing receptors.''; Steroids, 2007 PubMed Europe PMC Scholia
  10. Le Vee M, Jouan E, Fardel O; ''Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.''; Toxicol In Vitro, 2010 PubMed Europe PMC Scholia
  11. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  12. Handschin C, Meyer UA; ''''; , PubMed Europe PMC Scholia
  13. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  14. Rochette-Egly C, Germain P; ''Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).''; Nucl Recept Signal, 2009 PubMed Europe PMC Scholia
  15. Li AC, Glass CK; ''''; , PubMed Europe PMC Scholia
  16. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalová J, Vondrácek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed Europe PMC Scholia
  17. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  18. Rodríguez-Sosa M, Elizondo G, López-Durán RM, Rivera I, Gonzalez FJ, Vega L; ''''; , PubMed Europe PMC Scholia
  19. Nilsson S, Gustafsson JÃ…; ''''; , PubMed Europe PMC Scholia
  20. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  21. Fijten RR, Jennen DG, van Delft JH; ''Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants.''; Curr Drug Metab, 2013 PubMed Europe PMC Scholia
  22. Haarmann-Stemmann T, Bothe H, Abel J; ''Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  23. Lindsey S, Papoutsakis ET; ''''; , PubMed Europe PMC Scholia
  24. Weiss C, Faust D, Dürk H, Kolluri SK, Pelzer A, Schneider S, Dietrich C, Oesch F, Göttlicher M; ''TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.''; Oncogene, 2005 PubMed Europe PMC Scholia
  25. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  26. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR; ''''; , PubMed Europe PMC Scholia
  27. Hashimoto K, Mori M; ''''; , PubMed Europe PMC Scholia
  28. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''''; , PubMed Europe PMC Scholia
  29. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T; ''''; , PubMed Europe PMC Scholia
  30. Gao H, Fält S, Sandelin A, Gustafsson JA, Dahlman-Wright K; ''Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.''; Mol Endocrinol, 2008 PubMed Europe PMC Scholia
  31. Jeon MS, Esser C; ''The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family.''; J Immunol, 2000 PubMed Europe PMC Scholia
  32. Rowlands JC, Gustafsson JA; ''Aryl hydrocarbon receptor-mediated signal transduction.''; Crit Rev Toxicol, 1997 PubMed Europe PMC Scholia
  33. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed Europe PMC Scholia
  34. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  35. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed Europe PMC Scholia
  36. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed Europe PMC Scholia
  37. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  38. Bock KW; ''''; , PubMed Europe PMC Scholia
  39. ''''; , PubMed Europe PMC Scholia
  40. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  41. Vezina CM, Walker NJ, Olson JR; ''Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.''; Environ Health Perspect, 2004 PubMed Europe PMC Scholia
  42. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  43. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ; ''The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  44. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  45. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed Europe PMC Scholia
  46. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  47. Krogsdam AM, Nielsen CA, Neve S, Holst D, Helledie T, Thomsen B, Bendixen C, Mandrup S, Kristiansen K; ''Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.''; Biochem J, 2002 PubMed Europe PMC Scholia
  48. Handschin C, Meyer UA; ''''; , PubMed Europe PMC Scholia
  49. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
116463view10:06, 7 May 2021EweitzModified title
88057view13:48, 25 July 2016SusanOntology Term : 'bile acid signaling pathway' added !
80916view15:31, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCB11GeneProductENSBTAG00000026885 (Ensembl)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 11
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8647
ABCB4GeneProductENSBTAG00000005653 (Ensembl)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5244
BAATGeneProductENSBTAG00000025760 (Ensembl)
  • bile acid CoA:amino acid N-acyltransferase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:570
CYP3A4GeneProductENSBTAG00000047379 (Ensembl)
  • cytochrome P450, family 3, subfamily A, polypeptide 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1576
CYP7A1GeneProductENSBTAG00000005287 (Ensembl)
  • cytochrome P450, family 7, subfamily A, polypeptide 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581
CYP8B1GeneProductENSBTAG00000034106 (Ensembl)
  • cytochrome P450, family 8, subfamily B, polypeptide 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1582
FGF19GeneProductENSBTAG00000017285 (Ensembl)
  • fibroblast growth factor 19
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9965
FKBP5GeneProductENSBTAG00000047502 (Ensembl)
  • FK506 binding protein 5
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2289
FXR ligandMetaboliteCHEBI:48705 (ChEBI) T3
IRS2GeneProductENSBTAG00000012019 (Ensembl)
  • insulin receptor substrate 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660
LigandMetaboliteCHEBI:48705 (ChEBI)
NR0B2GeneProductENSBTAG00000014848 (Ensembl)
  • nuclear receptor subfamily 0, group B, member 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8431
NR1H4GeneProductENSBTAG00000013596 (Ensembl)
  • nuclear receptor subfamily 1, group H, member 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9971
PPARGC1AGeneProductENSBTAG00000017024 (Ensembl)
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10891
RXRAGeneProductENSBTAG00000017851 (Ensembl)
  • retinoid X receptor, alpha
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6256
SLC10A1GeneProductENSBTAG00000001881 (Ensembl)
  • solute carrier family 10 (sodium/bile acid cotransporter), member 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6554
SLC27A5GeneProductENSBTAG00000015164 (Ensembl)
  • solute carrier family 27 (fatty acid transporter), member 5
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10998
SLCO2B1GeneProductENSBTAG00000015596 (Ensembl)
  • solute carrier organic anion transporter family, member 2B1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11309
SULT2A1GeneProductENSBTAG00000039971 (Ensembl)
  • sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6822
UGT2B4GeneProductENSBTAG00000040337 (Ensembl)
  • UDP glucuronosyltransferase 2 family, polypeptide B4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7363
UQCC2GeneProductENSBTAG00000033603 (Ensembl)
  • inositol hexakisphosphate kinase 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:117283

Annotated Interactions

No annotated interactions
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