Nanomaterial-induced inflammasome activation (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Farrera C, Fadeel B; ''It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system.''; Eur J Pharm Biopharm, 2015 PubMed Europe PMC Scholia
2. Bhattacharya K, Andón FT, El-Sayed R, Fadeel B; ''Mechanisms of carbon nanotube-induced toxicity: focus on pulmonary inflammation.''; Adv Drug Deliv Rev, 2013 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	124504	view	08:41, 3 November 2022	JPM van Rijn	Modified description
	116457	view	10:02, 7 May 2021	Eweitz	Modified title
	110231	view	14:27, 27 April 2020	Egonw	Not a mim-conversion
	109788	view	01:37, 1 April 2020	AlexanderPico	Modified title
	109787	view	01:35, 1 April 2020	AlexanderPico	updated xrefs and layout
	106757	view	13:24, 17 September 2019	MaintBot	HMDB identifier normalization
	94756	view	15:35, 5 October 2017	Mkutmon	fix unconnected lines
	92318	view	08:51, 20 May 2017	Egonw	Ontology Term : 'nanomaterial response pathway' added !
	92313	view	08:47, 20 May 2017	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
	91312	view	19:08, 26 January 2017	Khanspers	Modified title
	89364	view	06:25, 8 September 2016	Torresandon	Modified description
	89363	view	06:13, 8 September 2016	Torresandon	PAMPs
	89362	view	06:07, 8 September 2016	Torresandon	Update TLR receptor and necessary stimuli for the activation of the pathway
	89305	view	13:23, 31 August 2016	Egonw	Ontology Term : 'regulatory pathway' added !
	89304	view	13:23, 31 August 2016	Egonw	Ontology Term : 'macrophage' added !
	89303	view	13:22, 31 August 2016	Egonw	Ontology Term : 'PW:0001018' removed !
	89302	view	13:22, 31 August 2016	Egonw	Ontology Term : 'innate immune response pathway' added !
	89301	view	13:21, 31 August 2016	Egonw	Ontology Term : 'immune system disease pathway' added !
	89286	view	13:09, 30 August 2016	Torresandon	Add references
	89285	view	13:06, 30 August 2016	Torresandon	Add references
	89284	view	12:13, 30 August 2016	Torresandon	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
ASC
Caspase-1 (Fragment)	Protein	H0YEC7 (Uniprot-TrEMBL)
Caspase-1	Protein	B4DVD8 (Uniprot-TrEMBL)
Cathepsin B	Protein	E9PCB3 (Uniprot-TrEMBL)
IL1B	GeneProduct	ENSG00000125538 (Ensembl)
IL1B	Protein	P01584 (Uniprot-TrEMBL)
LPS core	Metabolite	HMDB13471 (HMDB)
NADPH oxidase 1	Protein	A6NGA6 (Uniprot-TrEMBL)
NFKB1	GeneProduct	NFKB1 (HGNC)
NLRP3	Protein	A0A024R5Q0 (Uniprot-TrEMBL)
Potassium	Metabolite	HMDB00586 (HMDB)
ROS production	Metabolite	CHEBI:26523 (ChEBI)
TLR2	GeneProduct	ENSG00000137462 (Ensembl)
TLR4	GeneProduct	ENSG00000136869 (Ensembl)
pro-IL-1b	Protein	P01584 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions